Results 41 to 50 of about 435,247 (293)

Unraveling molecular similarities between colorectal polyps and colorectal cancer: a systems biology approach [PDF]

Intestinal Research
Background/Aims Colorectal cancer (CRC) and colorectal polyps are intimately linked, with polyps acting as precursors to CRC. Understanding the molecular mechanisms governing their development is crucial for advancing diagnosis and treatment. Employing a
Mehran Radak, Hossein Fallahi
doaj   +1 more source

Nodes with high centrality in protein interaction networks are responsible for driving signaling pathways in diabetic nephropathy [PDF]

PeerJ, 2015
In spite of huge efforts, chronic diseases remain an unresolved problem in medicine. Systems biology could assist to develop more efficient therapies through providing quantitative holistic sights to these complex disorders.
Maryam Abedi, Yousof Gheisari
doaj   +2 more sources

PTOMSM: A modified version of Topological Overlap Measure used for predicting Protein-Protein Interaction Network

, 2009
A variety of methods are developed to integrating diverse biological data to predict novel interaction relationship between proteins. However, traditional integration can only generate protein interaction pairs within existing relationships.
Xun Huang
core   +1 more source

Studies on the interaction between "Tobacco Mosaic Virus" movement protein and microtubules [PDF]

, 2003
During the invasion of a susceptible host, Tobacco mosaic virus (TMV) transports its RNA genome from sites of viral synthesis into neighbouring cells, thus potentiating the spread of infection.
Ashby, Jamie A.
core   +1 more source

Sequence Motifs in MADS Transcription Factors Responsible for Specificity and Diversification of Protein-Protein Interaction

, 2010
Protein sequences encompass tertiary structures and contain information about specific molecular interactions, which in turn determine biological functions of proteins.
Angenent, G.C., Martijn Fiers, Roeland C H J van Ham, Roeland C. H. J. van Ham, Morabito Giuseppa, Ham, R.C.H.J., van, Aalt D J van Dijk, Angenent Gerco C., Immink, R.G.H., van Dijk, A.D.J., Richard G H Immink, van Dijk Aalt D. J., Morabito, G., van Ham Roeland C. H. J., Dijk, A.D.J., van, Fiers, M.A., Richard G. H. Immink, Giuseppa Morabito, van Ham, R.C.H.J., Aalt D. J. van Dijk, Immink Richard G. H., Gerco C Angenent, Gerco C. Angenent, Fiers Martijn   +23 more
core   +1 more source

Effectiveness of a Novel Low‐Density Lipoprotein Apheresis Device Rheocarna in Patients Undergoing Hemodialysis With Chronic Limb‐Threatening Ischemia: A Single‐Center Retrospective Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic limb‐threatening ischemia (CLTI) is a severe form of lower‐extremity artery disease characterized by distal lesions and microcirculatory impairment, limiting revascularization efficacy. Rheocarna is a direct hemoperfusion low‐density lipoprotein (LDL) adsorption device with potential rheological and anti‐inflammatory ...
Kunihiro Ishioka, Takayasu Ohtake, Kei Ohmori, Chika Shibuya, Tomoki Tsukahara, Mizuki Yamano, Yasuhiro Mochida, Machiko Oka, Kyoko Maesato, Yusuke Tsukamoto, Hidekazu Moriya, Sumi Hidaka, Shuzo Kobayashi   +12 more
wiley   +1 more source

In silico analysis of Ziziphus mauritiana Lam. bioactive compounds targeting GABA receptor and ADMET profiles for potential postpartum depression treatment [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Postpartum depression (PPD) affects 10–20% of women and has been associated with disruptions in neurotransmitter systems, neuroinflammation, and oxidative stress.
Ruri Y. Astari, Sri Winarsih, Dian Handayani, Heni D. Windarwati, Holipah, Bambang Rahardjo   +5 more
doaj   +1 more source

The plant endoplasmic reticulum UPRome: A repository and pathway browser for genes involved in signaling networks linked to the endoplasmic reticulum

Plant Direct, 2022
The endoplasmic reticulum (ER) houses sensors that respond to environmental stress and underly plants' adaptative responses. These sensors transduce signals that lead to changes in nuclear gene expression.
Venura Herath, Kaylee Connolly, Anna Roach, Ashish Ausekar, Tracy Persky, Jeanmarie Verchot   +5 more
doaj   +1 more source

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
openaire   +2 more sources