Results 61 to 70 of about 435,247 (293)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Building multi-layer social knowledge maps with google maps API [PDF]

, 2012
Google Maps is an intuitive online-map service which changes people's way of navigation on Geo-maps. People can explore the maps in a multi-layer fashion in order to avoid information overloading.
Guerra, Julio, Liang, ME, Liang, Miner, Guerra, J, Brusilovsky, Peter, Brusilovsky, P   +5 more
core  

A transient homotypic interaction model for the influenza A virus NS1 protein effector domain [PDF]

, 2011
Influenza A virus NS1 protein is a multifunctional virulence factor consisting of an RNA binding domain (RBD), a short linker, an effector domain (ED), and a C-terminal 'tail'. Although poorly understood, NS1 multimerization may autoregulate its actions.
Margaret A Taylor, Richard E. Randall, García-Sastre, A., Hale Benjamin G., Kerry, P.S., Lewis Andrew, Taylor Margaret A., Kerry, Philip S., Andrew Lewis, Kerry Philip S., Hass, C., Benjamin G. Hale, Hale, Benjamin G., Rupert J. Russell, Juan Ayllon, Richard E Randall, Randall Richard E., Hale, B.G., Margaret A. Taylor, Ayllon, Juan, Philip S Kerry, Randall, R.E., Adolfo García-Sastre, Ayllón Barasoain, Juan, Lewis, Andrew, Hass Claudia, Ayllon, J., Rupert J Russell, García Sastre, Adolfo, Taylor, M.A., Lewis, A., García-Sastre Adolfo, Taylor, Margaret A., Hass, Claudia, Ayllon Juan, Russell, R.J., Randall, Richard E., Claudia Hass, Russell, Rupert J., Benjamin G Hale, Russell Rupert J., Philip S. Kerry, Garcia-Sastre, Adolfo   +42 more
core   +1 more source

A Protein-Protein Interaction Map of Trypanosome ∼20S Editosomes [PDF]

Journal of Biological Chemistry, 2010
Mitochondrial mRNA editing in trypanosomatid parasites involves several multiprotein assemblies, including three very similar complexes that contain the key enzymatic editing activities and sediment at ~20S on glycerol gradients. These ~20S editosomes have a common set of 12 proteins, including enzymes for uridylyl (U) removal and addition, 2 RNA ...
Achim, Schnaufer, Meiting, Wu, Young-jun, Park, Tadashi, Nakai, Junpeng, Deng, Rose, Proff, Wim G J, Hol, Kenneth D, Stuart   +7 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The retinoblastoma protein modulates Tbx2 functional specificity [PDF]

, 2010
Tbx2 is a member of a large family of transcription factors defined by homology to the T-box DNA-binding domain. Tbx2 plays a key role in embryonic development, and in cancer through its capacity to suppress senescence and promote invasiveness.
Colin R. Goding, Goding, CR, Heather M. Shaw, Sascha Ott, Keith W. Vance, Vance, KW, Shaw, HM, Mercedes Rodriguez, Ott, S, Rodriguez, Mercedes, Goding, Colin R., Ott, Sascha, Shaw, Heather M., Rodriguez, M, Vance, Keith W.   +14 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Introducing Genes With Significant Role in Migraine: An Interactomic Approach

Basic and Clinical Neuroscience, 2019
Introduction: Migraine is a severe kind of headache with the chance hereditary of 50%. Molecular studies can promote understanding of migraine pathophysiology.
Mona Zamanian-Azodi, Mostafa Rezaei-Tavirani, Reza Mahmoud Robati   +2 more
doaj  

Reverse PCA, a systematic approach for identifying genes important for the physical interaction between protein pairs. [PDF]

PLoS Genetics, 2013
Protein-protein interactions (PPIs) are of central importance for many areas of biological research. Several complementary high-throughput technologies have been developed to study PPIs.
Ifat Lev, Marina Volpe, Liron Goor, Nelly Levinton, Liach Emuna, Shay Ben-Aroya   +5 more
doaj   +1 more source