Results 71 to 80 of about 8,260,919 (293)

In silico analysis of Ziziphus mauritiana Lam. bioactive compounds targeting GABA receptor and ADMET profiles for potential postpartum depression treatment [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Postpartum depression (PPD) affects 10–20% of women and has been associated with disruptions in neurotransmitter systems, neuroinflammation, and oxidative stress.
Ruri Y. Astari, Sri Winarsih, Dian Handayani, Heni D. Windarwati, Holipah, Bambang Rahardjo   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Toward an understanding of the protein interaction network of the human liver

Molecular Systems Biology, 2011
Proteome‐scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery.
Jian Wang, Keke Huo, Lixin Ma, Liujun Tang, Dong Li, Xiaobi Huang, Yanzhi Yuan, Chunhua Li, Wei Wang, Wei Guan, Hui Chen, Chaozhi Jin, Junchen Wei, Wanqiao Zhang, Yongsheng Yang, Qiongming Liu, Ying Zhou, Cuili Zhang, Zhihao Wu, Wangxiang Xu, Ying Zhang, Tao Liu, Donghui Yu, Yaping Zhang, Liang Chen, Dewu Zhu, Xing Zhong, Lixin Kang, Xiang Gan, Xiaolan Yu, Qi Ma, Jing Yan, Li Zhou, Zhongyang Liu, Yunping Zhu, Tao Zhou, Fuchu He, Xiaoming Yang   +37 more
doaj   +1 more source

Integrated proteomics identifies a dysfunctional acrosomal module associated with impaired acrosome reaction in asthenozoospermia [PDF]

Journal of Men's Health
Background: Asthenozoospermia, a primary cause of male infertility, is characterized not only by reduced sperm motility, but also by functional impairments, particularly defects in the acrosome reaction.
Andu Zhu, Jie Zhu, Dongdong Jin
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Differential network biology

Molecular Systems Biology, 2012
Protein and genetic interaction maps can reveal the overall physical and functional landscape of a biological system. To date, these interaction maps have typically been generated under a single condition, even though biological systems undergo ...
Trey Ideker, Nevan J Krogan
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

PEPpip: A Vision-Inspired Explainable Deep Learning Framework for Sequence-Based Protein–Protein Interaction Prediction and Interaction Map Estimation

IEEE Access
Predicting protein–protein interaction (PPI) patterns from primary sequences constitutes a complex pattern recognition task that demands advanced and explainable deep learning frameworks, as PPIs underpin critical cellular and pathological ...
Shubhrangshu Ghosh, Pralay Mitra
doaj   +1 more source

Reverse PCA, a systematic approach for identifying genes important for the physical interaction between protein pairs. [PDF]

PLoS Genetics, 2013
Protein-protein interactions (PPIs) are of central importance for many areas of biological research. Several complementary high-throughput technologies have been developed to study PPIs.
Ifat Lev, Marina Volpe, Liron Goor, Nelly Levinton, Liach Emuna, Shay Ben-Aroya   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source