Results 91 to 100 of about 435,247 (293)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Where have all the interactions gone? Estimating the coverage of two-hybrid protein interaction maps.

PLoS Computational Biology, 2007
Yeast two-hybrid screens are an important method for mapping pairwise physical interactions between proteins. The fraction of interactions detected in independent screens can be very small, and an outstanding challenge is to determine the reason for the ...
Hailiang Huang, Bruno M Jedynak, Joel S Bader   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Computational identification of phospho-tyrosine sub-networks related to acanthocyte generation in neuroacanthocytosis [PDF]

, 2012
Acanthocytes, abnormal thorny red blood cells (RBC), are one of the biological hallmarks of neuroacanthocytosis syndromes (NA), a group of rare hereditary neurodegenerative disorders.
Pantaleo, Antonella, Angela Siciliano, Jung, Hans H., Pantaleo A., Ruth H. Walker (184548), Dotti Maria Teresa, Bader B., Sara Mazzucco, Lucia De Franceschi (184533), Dotti, Maria Teresa, Tomelleri Carlo, Bader, B, Hans H. Jung (184555), Walker R. H., Mazzucco, Sara, Walker, R H, Scardoni, G, Danek, A, Carlo Tomelleri, Giovanni Scardoni, Sara Mazzucco (184565), Scardoni G, Bader Benedikt, Dotti, M T, Siciliano, Angela, Danek, Adrian, Tomelleri C, Lucia De Franceschi, Giovanni Scardoni (184538), Adrian Danek, Antonella Pantaleo (184574), Pantaleo, A, Pantaleo Antonella, Laudanna Carlo, Jung H. H., Benedikt Bader, Adrian Danek (4947), De Franceschi Lucia, Scardoni G., Siciliano A, Antonella Pantaleo, Danek Adrian, Tomelleri, Carlo, Hans H Jung, Jung, H H, Carlo Laudanna (184575), Laudanna C., Benedikt Bader (184560), Jung Hans H., DOTTI, MARIA, De Franceschi L, Jung HH, Tomelleri, C, Walker RH, De Franceschi, L, Pantaleo A, Laudanna, Carlo, Danek A, Carlo Laudanna, Siciliano, A, De Franceschi, Lucia, Maria Teresa Dotti (184569), Walker Ruth H., Scardoni, Giovanni, Ruth H Walker, Maria Teresa Dotti, Mazzucco Sara, Bader B, Scardoni Giovanni, Mazzucco, S, Dotti M. T., Laudanna, C, Angela Siciliano (184571), Siciliano Angela, Carlo Tomelleri (184542), Walker, Ruth H., Bader, Benedikt, Mazzucco S, Danek A.   +78 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1 [PDF]

, 2005
Latexin, the only known mammalian carboxypeptidase inhibitor, has no detectable sequence similarity with plant and parasite inhibitors, but it is related to a human putative tumor suppressor protein, TIG1.
Listwan, P., Flanagan, Jack U., Flanagan, JU, Martin, Jennifer L, Listwan, P, Wells, Christine A, Kobe, Bostjan, Hume, DA, Cowieson, Nathan, Martin, Jennifer L., Hume, D A, Ravasi, T., Listwan, Pawel, Kellie, S, Kobe, B., Martin, Jennifer Louise, Cowieson, N. P., Martin, J. L., Huber, T, Huber, Thomas, Aagaard, A, Kobe, B, Flanagan, J. U., Ravasi, Timothy, Aagaard, A., A. Wells, Christine, Wells, C. A., Wells, Christine A., Aagaard, Anna, Wells, Christine, Flanagan, Jack U, Cowieson, N, Kellie, S., Huber, T. L., Hume, David A, Hume, D. A., Kellie, Stuart, Ravasi, T, Hume, David A., Wells, CA, Martin, JL   +40 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Discover Protein Complexes in Protein-Protein Interaction Networks Using Parametric Local Modularity

BMC Bioinformatics, 2010
Background Recent advances in proteomic technologies have enabled us to create detailed protein-protein interaction maps in multiple species and in both normal and diseased cells.
Tan Kai, Kim Jongkwang
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source