Results 1 to 10 of about 271,486 (262)

Global pairwise RNA interaction landscapes reveal core features of protein recognition

Nature Communications, 2018
RNA–protein interactions often depend on the recognition of extended RNA elements but the identification of these motifs is challenging. Here, the authors present a global integrated approach to analyze RNA–protein binding landscapes, mapping extended ...
Qin Zhou, Nikesh Kunder, José Alberto De la Paz, Alexandra E. Lasley, Vandita D. Bhat, Faruck Morcos, Zachary T. Campbell   +6 more
doaj   +1 more source

Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a TIP60-independent regulation of the pre-RC complex

iScience, 2023
Summary: Bromodomain-containing protein 8 (BRD8) is a subunit of the NuA4/TIP60-histone acetyltransferase complex. Although BRD8 has been considered to act as a co-activator of the complex, its biological role remains to be elucidated. Here, we uncovered
Kiyoshi Yamaguchi, Saya Nakagawa, Akari Saku, Yumiko Isobe, Rui Yamaguchi, Paul Sheridan, Kiyoko Takane, Tsuneo Ikenoue, Chi Zhu, Masashi Miura, Yuya Okawara, Satoru Nagatoishi, Hiroko Kozuka-Hata, Masaaki Oyama, Susumu Aikou, Yuka Ahiko, Dai Shida, Kouhei Tsumoto, Satoru Miyano, Seiya Imoto, Yoichi Furukawa   +20 more
doaj   +1 more source

Conserved and variable correlated mutations in the plant MADS protein network [PDF]

, 2010
Background Plant MADS domain proteins are involved in a variety of developmental processes for which their ability to form various interactions is a key requisite.
Dijk, A.D.J., van, van Dijk Aalt DJ, Roeland CHJ van Ham, Ham, R.C.H.J., van, van Dijk, A.D.J., van Ham, R.C.H.J., Aalt DJ van Dijk, van Ham Roeland CHJ   +7 more
core   +1 more source

Simple Ligand–Receptor Interaction Descriptor (SILIRID) for alignment-free binding site comparison

Computational and Structural Biotechnology Journal, 2014
We describe SILIRID (Simple Ligand–Receptor Interaction Descriptor), a novel fixed size descriptor characterizing protein–ligand interactions. SILIRID can be obtained from the binary interaction fingerprints (IFPs) by summing up the bits corresponding to
Vladimir Chupakhin, Gilles Marcou, Helena Gaspar, Alexandre Varnek   +3 more
doaj   +1 more source

Characterisation of the E.coli and Pseudomonas aeruginosa TolA-TolB interaction [PDF]

, 2012
The Tol-Pal complex of Gram-negative bacteria is a highly conserved family of interacting proteins that span the periplasm, from inner to outer membrane.
Cassels, Eoin
core  

Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway

Molecular Systems Biology, 2009
Large‐scale proteomic approaches have been used to study signaling pathways. However, identification of biologically relevant hits from a single screen remains challenging due to limitations inherent in each individual approach.
Bryan W Miller, Garnet Lau, Chris Grouios, Emanuela Mollica, Miriam Barrios‐Rodiles, Yongmei Liu, Alessandro Datti, Quaid Morris, Jeffrey L Wrana, Liliana Attisano   +9 more
doaj   +1 more source

Interactive proteomics: what lies ahead?

BioTechniques, 2008
Interactive proteomics addresses the physical associations among proteins and establishes global, disease-, and pathway-specific protein interaction networks.
Bernhard Suter, Saranya Kittanakom, Igor Stagljar   +2 more
doaj   +1 more source

Computational Analyses of Protein-Ligand Interactions [PDF]

, 2010
Protein-ligand interactions have a central role in all processes in living systems. A comprehensive understanding of protein interactions with small molecules is of great interest as it provides opportunities for understanding protein function and ...
Haider, Kamran
core  

Four and a half LIM protein 1C (FHL1C) [PDF]

, 2011
Four-and-a-half LIM domain protein 1 isoform A (FHL1A) is predominantly expressed in skeletal and cardiac muscle. Mutations in the FHL1 gene are causative for several types of hereditary myopathies including X-linked myopathy with postural muscle atrophy
Quasthoff, Stefan, Schreibmayer, Wolfgang, Schoser, Benedikt, Wagner, Klaus, Windpassinger, Christian, Poparic, Ivana, Hochmeister, Sonja, Binder, Josepha, Gorischek, Astrid, Malle, Ernst, Desoye, Gernot, Miedl, Heidi   +11 more
core   +1 more source

PCSF: An R-package for network-based interpretation of high-throughput data. [PDF]

PLoS Computational Biology, 2017
With the recent technological developments a vast amount of high-throughput data has been profiled to understand the mechanism of complex diseases. The current bioinformatics challenge is to interpret the data and underlying biology, where efficient ...
Murodzhon Akhmedov, Amanda Kedaigle, Renan Escalante Chong, Roberto Montemanni, Francesco Bertoni, Ernest Fraenkel, Ivo Kwee   +6 more
doaj   +1 more source