Results 1 to 10 of about 543,435 (291)
Role of solvent for globular proteins in solution
, 2005 The properties of the solvent affect the behavior of the solution. We propose a model that accounts for the contribution of the solvent free energy to the free energy of globular proteins in solution.
Andrey Shiryayev +6 more
core +1 more source
Do peers see more in a paper than its authors? [PDF]
, 2012 Recent years have shown a gradual shift in the content of biomedical publications that is freely accessible, from titles and abstracts to full text. This has enabled new forms of automatic text analysis and has given rise to some interesting questions ...
Divoli, Anna +2 more
core +3 more sources
Genetic interaction mapping of Aurora protein kinases in mouse oocytes
Frontiers in Cell and Developmental BiologyThe Aurora Kinases (AURKs) are a family of serine-threonine protein kinases critical for cell division. Somatic cells express only AURKA and AURKB. However, mammalian germ cells and some cancer cells express all three isoforms.
Cecilia S. Blengini +3 more
doaj +1 more source
Global pairwise RNA interaction landscapes reveal core features of protein recognition
Nature Communications, 2018 RNA–protein interactions often depend on the recognition of extended RNA elements but the identification of these motifs is challenging. Here, the authors present a global integrated approach to analyze RNA–protein binding landscapes, mapping extended ...
Qin Zhou +6 more
doaj +1 more source
Structural and biochemical insights of CypA and AIF interaction [PDF]
, 2017 The Cyclophilin A (CypA)/Apoptosis Inducing Factor (AIF) complex is implicated in the DNA degradation in response to various cellular stress conditions, such as oxidative stress, cerebral hypoxia-ischemia and traumatic brain injury.
Caporale, Andrea +10 more
core +1 more source
Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments [PDF]
, 2003 Spinophilin is a protein phosphatase 1 (PP1)- and actin-binding protein that modulates excitatory synaptic transmission and dendritic spine morphology. We report that spinophilin is phosphorylated in vitro by protein kinase A (PKA).
Allen, Patrick B. +5 more
core
Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics' [PDF]
, 2005 We combined large-scale mRNA expression analysis and gene mapping to identify genes and loci that control hematopoietic stem cell (HSC) function. We measured mRNA expression levels in purified HSCs isolated from a panel of densely genotyped recombinant ...
A Scherer +24 more
core +2 more sources
Simple Ligand–Receptor Interaction Descriptor (SILIRID) for alignment-free binding site comparison
Computational and Structural Biotechnology Journal, 2014 We describe SILIRID (Simple Ligand–Receptor Interaction Descriptor), a novel fixed size descriptor characterizing protein–ligand interactions. SILIRID can be obtained from the binary interaction fingerprints (IFPs) by summing up the bits corresponding to
Vladimir Chupakhin +3 more
doaj +1 more source
Interactive proteomics: what lies ahead?
BioTechniques, 2008 Interactive proteomics addresses the physical associations among proteins and establishes global, disease-, and pathway-specific protein interaction networks.
Bernhard Suter +2 more
doaj +1 more source
Molecular Systems Biology, 2009 Large‐scale proteomic approaches have been used to study signaling pathways. However, identification of biologically relevant hits from a single screen remains challenging due to limitations inherent in each individual approach.
Bryan W Miller +9 more
doaj +1 more source