Results 11 to 20 of about 7,803,058 (302)

Systematic protein–protein interaction mapping for clinically relevant human GPCRs [PDF]

Molecular Systems Biology, 2017
G‐protein‐coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex ...
Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar   +27 more
doaj   +2 more sources

Fundamentals of protein interaction network mapping

Molecular Systems Biology, 2015
Studying protein interaction networks of all proteins in an organism (“interactomes”) remains one of the major challenges in modern biomedicine. Such information is crucial to understanding cellular pathways and developing effective therapies for the ...
Jamie Snider, Max Kotlyar, Punit Saraon, Zhong Yao, Igor Jurisica, Igor Stagljar   +5 more
doaj   +3 more sources

Library-based, multiplexed strategy for mapping protein interaction networks via crosslinking [PDF]

BMC Biotechnology
Background Protein-protein interactions are fundamental to cellular function, yet resolving their interaction interfaces and dynamic behaviors in native biological contexts remains challenging, particularly for weak or transient interactions ...
Yuxin Lu, Shuting Meng, Yi Zhang, Fei Wang, Tingting Shi, Yijia Chi, Song Chen, Dongxin Zhao   +7 more
doaj   +2 more sources

Author Correction: Systematic protein-protein interaction mapping for clinically relevant human GPCRs [PDF]

Molecular Systems Biology
Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi-Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar   +27 more
doaj   +2 more sources

Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication. [PDF]

Cell, 2018
Batra J, Hultquist JF, Liu D, Shtanko O, Von Dollen J, Satkamp L, Jang GM, Luthra P, Schwarz TM, Small GI, Arnett E, Anantpadma M, Reyes A, Leung DW, Kaake R, Haas P, Schmidt CB, Schlesinger LS, LaCount DJ, Davey RA, Amarasinghe GK, Basler CF, Krogan NJ.   +22 more
europepmc   +2 more sources

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. [PDF]

Mol Cell, 2016
Floyd BJ, Wilkerson EM, Veling MT, Minogue CE, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JP, Coon JJ, Pagliarini DJ.   +23 more
europepmc   +2 more sources

Mapping of domain-mediated protein-protein interaction by SPOT peptide assay

STAR Protocols, 2021
Summary: Identification of peptides mediating protein-protein interaction (PPI) is crucial for understanding the function of interlinked proteins in cellular processes and amino acid-associated diseases.
Xiaoyi Mao, Godwin Sokpor, Jochen Staiger, Huu Phuc Nguyen, Tran Tuoc   +4 more
doaj   +1 more source

A Protein Interaction Map of the Mitotic Spindle [PDF]

Molecular Biology of the Cell, 2007
The mitotic spindle consists of a complex network of proteins that segregates chromosomes in eukaryotes. To strengthen our understanding of the molecular composition, organization, and regulation of the mitotic spindle, we performed a system-wide two-hybrid screen on 94 proteins implicated in spindle function in Saccharomyces cerevisiae. We report 604
Wong, Jonathan, Nakajima, Yuko, Westermann, Stefan, Shang, Ching, Kang, Jung-Seog, Goodner, Crystal, Houshmand, Pantea, Fields, Stanley, Chan, Clarence S.M., Drubin, David, Barnes, Georjana, Hazbun, Tony R   +11 more
openaire   +3 more sources

Mapping protein–DNA interactions with DiMeLo-seq [PDF]

Nature Protocols, 2022
Abstract We recently developed Di rected Me thylation with Lo ng-read seq uencing (DiMeLo-seq) to map protein-DNA interactions genome wide.
Annie Maslan, Nicolas Altemose, Reet Mishra, Jeremy Marcus, Lucy D. Brennan, Kousik Sundararajan, Gary Karpen, Aaron F. Straight, Aaron Streets   +8 more
openaire   +3 more sources

Mapping of protein-protein interaction sites in the plant-type [2Fe-2S] ferredoxin. [PDF]

PLoS ONE, 2011
Knowing the manner of protein-protein interactions is vital for understanding biological events. The plant-type [2Fe-2S] ferredoxin (Fd), a well-known small iron-sulfur protein with low redox potential, partitions electrons to a variety of Fd-dependent ...
Haruka Kameda, Kei Hirabayashi, Kei Wada, Keiichi Fukuyama   +3 more
doaj   +1 more source