Results 11 to 20 of about 543,435 (291)

Systematic protein–protein interaction mapping for clinically relevant human GPCRs [PDF]

Molecular Systems Biology, 2017
G‐protein‐coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex ...
Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar   +27 more
doaj   +2 more sources

Fundamentals of protein interaction network mapping

Molecular Systems Biology, 2015
Studying protein interaction networks of all proteins in an organism (“interactomes”) remains one of the major challenges in modern biomedicine. Such information is crucial to understanding cellular pathways and developing effective therapies for the ...
Jamie Snider, Max Kotlyar, Punit Saraon, Zhong Yao, Igor Jurisica, Igor Stagljar   +5 more
doaj   +3 more sources

Author Correction: Systematic protein-protein interaction mapping for clinically relevant human GPCRs [PDF]

Molecular Systems Biology
Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi-Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar   +27 more
doaj   +2 more sources

Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication. [PDF]

Cell, 2018
Batra J, Hultquist JF, Liu D, Shtanko O, Von Dollen J, Satkamp L, Jang GM, Luthra P, Schwarz TM, Small GI, Arnett E, Anantpadma M, Reyes A, Leung DW, Kaake R, Haas P, Schmidt CB, Schlesinger LS, LaCount DJ, Davey RA, Amarasinghe GK, Basler CF, Krogan NJ.   +22 more
europepmc   +2 more sources

Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis. [PDF]

Cell, 2018
Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ.   +35 more
europepmc   +2 more sources

Mapping of domain-mediated protein-protein interaction by SPOT peptide assay

STAR Protocols, 2021
Summary: Identification of peptides mediating protein-protein interaction (PPI) is crucial for understanding the function of interlinked proteins in cellular processes and amino acid-associated diseases.
Xiaoyi Mao, Godwin Sokpor, Jochen Staiger, Huu Phuc Nguyen, Tran Tuoc   +4 more
doaj   +1 more source

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. [PDF]

Mol Cell, 2016
Floyd BJ, Wilkerson EM, Veling MT, Minogue CE, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JP, Coon JJ, Pagliarini DJ.   +23 more
europepmc   +2 more sources

Mapping protein–DNA interactions with DiMeLo-seq [PDF]

Nature Protocols, 2022
AbstractWe recently developedDirectedMethylation withLong-readsequencing (DiMeLo-seq) to map protein-DNA interactions genome wide. DiMeLo-seq is capable of mapping multiple interaction sites on single DNA molecules, profiling protein binding in the context of endogenous DNA methylation, identifying haplotype specific protein-DNA interactions, and ...
Annie Maslan, Nicolas Altemose, Reet Mishra, Jeremy Marcus, Lucy D. Brennan, Kousik Sundararajan, Gary Karpen, Aaron F. Straight, Aaron Streets   +8 more
openaire   +3 more sources

Mapping of protein-protein interaction sites in the plant-type [2Fe-2S] ferredoxin. [PDF]

PLoS ONE, 2011
Knowing the manner of protein-protein interactions is vital for understanding biological events. The plant-type [2Fe-2S] ferredoxin (Fd), a well-known small iron-sulfur protein with low redox potential, partitions electrons to a variety of Fd-dependent ...
Haruka Kameda, Kei Hirabayashi, Kei Wada, Keiichi Fukuyama   +3 more
doaj   +1 more source

Detecting Mutually Exclusive Interactions in Protein-Protein Interaction Maps

PLoS ONE, 2012
Comprehensive protein interaction maps can complement genetic and biochemical experiments and allow the formulation of new hypotheses to be tested in the system of interest. The computational analysis of the maps may help to focus on interesting cases and thereby to appropriately prioritize the validation experiments.
Carmen Sanchez Claros, TRAMONTANO, ANNA
openaire   +9 more sources