Results 11 to 20 of about 292,859 (260)

Identification of Breast Cancer Biomarkers by Constructing Protein-Protein Interaction and miRNAs-mRNAs Networks [PDF]

Middle East Journal of Cancer
Background: In cancer-related diseases, early detection and control of disease progression are very important for successful treatment. Breast cancer is a significant problem due to its high mortality rate in the female population worldwide. By the early
Azizeh Asadzadeh, Bita Behboodian, Parsa Bernoos, Masoumeh Shojaei Barjouei   +3 more
doaj   +1 more source

Proteome-wide prediction and analysis of the Cryptosporidium parvum protein–protein interaction network through integrative methods

Computational and Structural Biotechnology Journal, 2022
As one of the most studied Apicomplexan parasite Cryptosporidium, Cryptosporidium parvum (C. parvum) causes worldwide serious diarrhea disease cryptosporidiosis, which can be deadly to immunodeficiency individuals, newly born children, and animals ...
Panyu Ren, Xiaodi Yang, Tianpeng Wang, Yunpeng Hou, Ziding Zhang   +4 more
doaj   +1 more source

A Rice Kinase-Protein Interaction Map     [PDF]

Plant Physiology, 2008
AbstractPlants uniquely contain large numbers of protein kinases, and for the vast majority of the 1,429 kinases predicted in the rice (Oryza sativa) genome, little is known of their functions. Genetic approaches often fail to produce observable phenotypes; thus, new strategies are needed to delineate kinase function.
Ding, Xiaodong, Richter, Todd, Chen, Mei, Fujii, Hiroaki, Seo, Young Su, Xie, Mingtang, Zheng, Xianwu, Kanrar, Siddhartha, Stevenson, Rebecca A, Dardick, Christopher, Li, Ying, Jiang, Hao, Zhang, Yan, Yu, Fahong, Bartley, Laura E, Chern, Mawsheng, Bart, Rebecca, Chen, Xiuhua, Zhu, Lihuang, Farmerie, William G, Gribskov, Michael, Zhu, Jian-Kang, Fromm, Michael E, Ronald, Pamela C, Song, Wen-Yuan   +24 more
openaire   +3 more sources

A protein interaction map of the LSU processome [PDF]

Genes & Development, 2015
Maturation of the large ribosomal subunit (LSU) in eukaryotes is a complex and highly coordinated process that requires the concerted action of a large, dynamic, ribonucleoprotein complex, the LSU processome. While we know that >80 ribosome biogenesis factors are required throughout the course of LSU assembly, little is known about how these factors
McCann, Kathleen L., Charette, J. Michael, Vincent, Nicholas G., Baserga, Susan J.   +3 more
openaire   +2 more sources

Mapping Transcriptome Data to Protein–Protein Interaction Networks of Inflammatory Bowel Diseases Reveals Disease-Specific Subnetworks

Frontiers in Genetics, 2021
Inflammatory bowel disease (IBD) is the common name for chronic disorders associated with the inflammation of the gastrointestinal tract. IBD is triggered by environmental factors in genetically susceptible individuals and has a significant number of ...
Sefika Feyza Maden, Saliha Ece Acuner
doaj   +1 more source

A Map of Interactions between the Proteins of a Retrotransposon [PDF]

Journal of Virology, 1998
ABSTRACTThe yeast two-hybrid system and in vitro binding assays were used to characterize 54 potential interactions between the proteins of Tf1, an LTR-retrotransposon found inSchizosaccharomyces pombe. The Tf1 integrase (IN) protein was found to interact strongly with itself and not with other control proteins.
S J, Steele, H L, Levin
openaire   +2 more sources

GST‐IVTT pull‐down: a fast and versatile in vitro method for validating and mapping protein–protein interactions

FEBS Open Bio, 2022
Over the past few decades, dozens of in vitro methods have been developed to map, investigate and validate protein–protein interactions. However, most of these approaches are time‐consuming and labour‐intensive or require specialised equipment or ...
Zsuzsánna Réthi‐Nagy, Edit Ábrahám, Zoltán Lipinszki   +2 more
doaj   +1 more source

Protein-protein interaction map for yeast TFIID [PDF]

Nucleic Acids Research, 2003
A major rate-limiting step in transcription initiation by RNA polymerase II is recognition and binding of the TATA element by the transcription factor TFIID. TFIID is composed of TATA binding protein (TBP) and approximately a dozen TBP-associated factors (TAFs).
Gayatri, Yatherajam, Lei, Zhang, Susan M, Kraemer, Laurie A, Stargell   +3 more
openaire   +2 more sources

Pan-cancer mapping of differential protein-protein interactions [PDF]

Scientific Reports, 2020
AbstractDeciphering the variations in the protein interactome is required to reach a systems-level understanding of tumorigenesis. To accomplish this task, we have considered the clinical and transcriptome data on >6000 samples from The Cancer Genome Atlas for 12 different cancers.
Gulfidan, Gizem, Turanli, Beste, Beklen, Hande, Sinha, Raghu, Arga, Kazim Yalcin   +4 more
openaire   +5 more sources

Comparison of human protein–protein interaction maps [PDF]

Bioinformatics, 2007
AbstractMotivation: Large-scale mappings of protein–protein interactions have started to give us new views of the complex molecular mechanisms inside a cell. After initial projects to systematically map protein interactions in model organisms such as yeast, worm and fly, researchers have begun to focus on the mapping of the human interactome. To tackle
Matthias E. Futschik, Gautam Chaurasia, Hanspeter Herzel   +2 more
openaire   +2 more sources