Results 11 to 20 of about 267,218 (263)

Fundamentals of protein interaction network mapping

Molecular Systems Biology, 2015
Studying protein interaction networks of all proteins in an organism (“interactomes”) remains one of the major challenges in modern biomedicine. Such information is crucial to understanding cellular pathways and developing effective therapies for the ...
Jamie Snider, Max Kotlyar, Punit Saraon, Zhong Yao, Igor Jurisica, Igor Stagljar   +5 more
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A Protein Interaction Map of the Mitotic Spindle [PDF]

Molecular Biology of the Cell, 2007
The mitotic spindle consists of a complex network of proteins that segregates chromosomes in eukaryotes. To strengthen our understanding of the molecular composition, organization, and regulation of the mitotic spindle, we performed a system-wide two-hybrid screen on 94 proteins implicated in spindle function in Saccharomyces cerevisiae. We report 604
Wong, Jonathan, Nakajima, Yuko, Westermann, Stefan, Shang, Ching, Kang, Jung-Seog, Goodner, Crystal, Houshmand, Pantea, Fields, Stanley, Chan, Clarence S.M., Drubin, David, Barnes, Georjana, Hazbun, Tony R   +11 more
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Mapping protein–DNA interactions with DiMeLo-seq [PDF]

Nature Protocols, 2022
Abstract We recently developed Di rected Me thylation with Lo ng-read seq uencing (DiMeLo-seq) to map protein-DNA interactions genome wide.
Annie Maslan, Nicolas Altemose, Reet Mishra, Jeremy Marcus, Lucy D. Brennan, Kousik Sundararajan, Gary Karpen, Aaron F. Straight, Aaron Streets   +8 more
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The protein interaction map of bacteriophage lambda [PDF]

BMC Microbiology, 2011
Bacteriophage lambda is a model phage for most other dsDNA phages and has been studied for over 60 years. Although it is probably the best-characterized phage there are still about 20 poorly understood open reading frames in its 48-kb genome. For a complete understanding we need to know all interactions among its proteins.
Rajagopala, Seesandra V., Casjens, Sherwood, Uetz, Peter   +2 more
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Detecting Mutually Exclusive Interactions in Protein-Protein Interaction Maps

PLoS ONE, 2012
Comprehensive protein interaction maps can complement genetic and biochemical experiments and allow the formulation of new hypotheses to be tested in the system of interest. The computational analysis of the maps may help to focus on interesting cases and thereby to appropriately prioritize the validation experiments.
Carmen Sanchez Claros, TRAMONTANO, ANNA
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A Rice Kinase-Protein Interaction Map     [PDF]

Plant Physiology, 2008
AbstractPlants uniquely contain large numbers of protein kinases, and for the vast majority of the 1,429 kinases predicted in the rice (Oryza sativa) genome, little is known of their functions. Genetic approaches often fail to produce observable phenotypes; thus, new strategies are needed to delineate kinase function.
Ding, Xiaodong, Richter, Todd, Chen, Mei, Fujii, Hiroaki, Seo, Young Su, Xie, Mingtang, Zheng, Xianwu, Kanrar, Siddhartha, Stevenson, Rebecca A, Dardick, Christopher, Li, Ying, Jiang, Hao, Zhang, Yan, Yu, Fahong, Bartley, Laura E, Chern, Mawsheng, Bart, Rebecca, Chen, Xiuhua, Zhu, Lihuang, Farmerie, William G, Gribskov, Michael, Zhu, Jian-Kang, Fromm, Michael E, Ronald, Pamela C, Song, Wen-Yuan   +24 more
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A protein interaction map of the LSU processome [PDF]

Genes & Development, 2015
Maturation of the large ribosomal subunit (LSU) in eukaryotes is a complex and highly coordinated process that requires the concerted action of a large, dynamic, ribonucleoprotein complex, the LSU processome. While we know that >80 ribosome biogenesis factors are required throughout the course of LSU assembly, little is known about how these factors
McCann, Kathleen L., Charette, J. Michael, Vincent, Nicholas G., Baserga, Susan J.   +3 more
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Identification of Breast Cancer Biomarkers by Constructing Protein-Protein Interaction and miRNAs-mRNAs Networks [PDF]

Middle East Journal of Cancer
Background: In cancer-related diseases, early detection and control of disease progression are very important for successful treatment. Breast cancer is a significant problem due to its high mortality rate in the female population worldwide. By the early
Azizeh Asadzadeh, Bita Behboodian, Parsa Bernoos, Masoumeh Shojaei Barjouei   +3 more
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A Map of Interactions between the Proteins of a Retrotransposon [PDF]

Journal of Virology, 1998
ABSTRACTThe yeast two-hybrid system and in vitro binding assays were used to characterize 54 potential interactions between the proteins of Tf1, an LTR-retrotransposon found inSchizosaccharomyces pombe. The Tf1 integrase (IN) protein was found to interact strongly with itself and not with other control proteins.
S J, Steele, H L, Levin
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Comparison of human protein–protein interaction maps [PDF]

Bioinformatics, 2007
AbstractMotivation: Large-scale mappings of protein–protein interactions have started to give us new views of the complex molecular mechanisms inside a cell. After initial projects to systematically map protein interactions in model organisms such as yeast, worm and fly, researchers have begun to focus on the mapping of the human interactome. To tackle
Matthias E. Futschik, Gautam Chaurasia, Hanspeter Herzel   +2 more
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