Results 41 to 50 of about 267,218 (263)

Bio::Homology::InterologWalk - A Perl module to build putative protein-protein interaction networks through interolog mapping

BMC Bioinformatics, 2011
Background Protein-protein interaction (PPI) data are widely used to generate network models that aim to describe the relationships between proteins in biological systems. The fidelity and completeness of such networks is primarily limited by the paucity
Armstrong J Douglas, Simpson T Ian, Gallone Giuseppe, Jarman Andrew P   +3 more
doaj   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
openaire   +2 more sources

Protocol for mapping differential protein-protein interaction networks using affinity purification-mass spectrometry

STAR Protocols
Summary: Proteins congregate into complexes to perform diverse cellular functions. Protein complexes are remodeled by protein-coding mutations or cellular signaling changes, driving phenotypic outcomes in health and disease.
Prashant Kaushal, Manisha R. Ummadi, Gwendolyn M. Jang, Yennifer Delgado, Sara K. Makanani, Kareem Alba, Declan M. Winters, Sophie F. Blanc, Jiewei Xu, Benjamin Polacco, Yuan Zhou, Erica Stevenson, Manon Eckhardt, Lorena Zuliani-Alvarez, Robyn Kaake, Danielle L. Swaney, Nevan J. Krogan, Mehdi Bouhaddou   +17 more
doaj   +1 more source

Illuminating spatial and temporal organization of protein interaction networks by mass spectrometry-based proteomics

Frontiers in Genetics, 2015
Protein-protein interactions are at the core of all cellular functions and dynamic alterations in protein interactions regulate cellular signaling. In the last decade, mass spectrometry-based proteomics has delivered unprecedented insights into human ...
Jiwen eYang, Sebastian Alexander Wagner, Petra eBeli   +2 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Multiplex mapping of protein-protein interaction interfaces

Proceedings of the National Academy of Sciences
Abstract We describe peptide mapping through Sp lit A ntibiotic R esistance C omplementation (SpARC-map), a method to identify the probable interface between two interacting ...
Jingxuan He, Ling-Nan Zou, Vidhi Pareek, Stephen J. Benkovic   +3 more
openaire   +4 more sources

From nonspecific DNA-protein encounter complexes to the prediction of DNA-protein interactions. [PDF]

PLoS Computational Biology, 2009
DNA-protein interactions are involved in many essential biological activities. Because there is no simple mapping code between DNA base pairs and protein amino acids, the prediction of DNA-protein interactions is a challenging problem. Here, we present a
Mu Gao, Jeffrey Skolnick
doaj   +1 more source

Structural and Evolutionary Insights Into the Binding of Host Receptors by the Rabies Virus Glycoprotein

Frontiers in Cellular and Infection Microbiology, 2021
Rabies represents a typical model for spillover of zoonotic viral diseases among multiple hosts. Understanding the success of rabies virus (RV) in switching hosts requires the analysis of viral evolution and host interactions.
Manar E. Khalifa, Manar E. Khalifa, Leonie Unterholzner, Muhammad Munir   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source