Results 41 to 50 of about 543,435 (291)

Drosophila Protein interaction Map (DPiM) [PDF]

Fly, 2012
Proteins perform essential cellular functions as part of protein complexes, often in conjunction with RNA, DNA, metabolites and other small molecules. The genome encodes thousands of proteins but not all of them are expressed in every cell type; and expressed proteins are not active at all times.
Guruharsha, K.G., Obar, Robert, Mintseris, Julian, Aishwarya, K., Krishnan, R.T., VijayRaghavan, K., Artavanis-Tsakonas, Spyros   +6 more
openaire   +3 more sources

InterAKTions with FKBPs - mutational and pharmacological exploration [PDF]

, 2013
The FK506-binding protein 51 (FKBP51) is an Hsp90-associated co-chaperone which regulates steroid receptors and kinases. In pancreatic cancer cell lines, FKBP51 was shown to recruit the phosphatase PHLPP to facilitate dephosphorylation of the kinase Akt,
Biondi, Ricardo M., Fabian, Anne-Katrin, Hausch, Felix, Kozany, Christian, März, Andreas, Neimanis, Sonja   +5 more
core   +3 more sources

Mass spectrometry‐based protein–protein interaction networks for the study of human diseases

Molecular Systems Biology, 2021
A better understanding of the molecular mechanisms underlying disease is key for expediting the development of novel therapeutic interventions. Disease mechanisms are often mediated by interactions between proteins. Insights into the physical rewiring of
Alicia L Richards, Manon Eckhardt, Nevan J Krogan   +2 more
doaj   +1 more source

Quantitative trait loci conferring grain mineral nutrient concentrations in durum wheat 3 wild emmer wheat RIL population [PDF]

, 2009
Mineral nutrient malnutrition, and particularly deficiency in zinc and iron, afflicts over 3 billion people worldwide. Wild emmer wheat, Triticum turgidum ssp. dicoccoides, genepool harbors a rich allelic repertoire for mineral nutrients in the grain.
A Blanco, A Blanco, A Börner, A Distelfeld, A Distelfeld, A Mesfin, A Morgounov, A Yilmaz, Abraham B. Korol, AH Paterson, AJ Barneix, Atilla Yazici, B Feil, BM Waters, C Groos, C Hotz, C Löffler, C Uauy, CN Law, CV Peterson, D Vreugdenhil, DF Calderini, E Nevo, F-X Oury, G Ladizinsky, GA Churchill, GB Gregorio, H Marschner, HE Bouis, Hikmet Budak, I Cakmak, I Cakmak, I Cakmak, I Cakmak, IA Khan, Ismail Cakmak, J Dvořák, JA McVittie, JCR Stangoulis, JL Gonzalez-Hernandez, JN Pearson, JNA Lott, JW Snape, L Avivi, L Gauer, Levent Ozturk, LR Joppa, M Cox, M Feldman, M Feldman, M Prasad, MA Grusak, MR Perretant, N Grotz, PA Sanchez, R Garnett, R Scarth, R Shi, RJ Larsen, RM Welch, RM Welch, S Abbo, S Harjit, S Huang, S McCouch, S Salvi, S Zanetti, SD Tanksley, SH Guzmán-Maldonado, TP O’Brien, Tzion Fahima, V Raboy, V Raboy, W Dijkshoorn, W Zhang, Y Genc, Yan Jun, Yehoshua Saranga, YI Ronin, Z Peleg, Z Peleg, Zvi Peleg   +81 more
core   +1 more source

Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label

Nature Communications, 2016
Mapping protein-protein interaction using crosslinking and mass spectroscopy strategies is hampered by a high rate of false-positive results. Here, the authors develop a genetically encoded photo-affinity probe for accurate identification of protein ...
Yi Yang, Haiping Song, Dan He, Shuai Zhang, Shizhong Dai, Shixian Lin, Rong Meng, Chu Wang, Peng R. Chen   +8 more
doaj   +1 more source

iRefIndex: A consolidated protein interaction database with provenance

BMC Bioinformatics, 2008
Background Interaction data for a given protein may be spread across multiple databases. We set out to create a unifying index that would facilitate searching for these data and that would group together redundant interaction data while recording the ...
Magklaras George, Razick Sabry, Donaldson Ian M   +2 more
doaj   +1 more source

Determining protein complex connectivity using a probabilistic deletion network derived from quantitative proteomics. [PDF]

PLoS ONE, 2009
Protein complexes are key molecular machines executing a variety of essential cellular processes. Despite the availability of genome-wide protein-protein interaction studies, determining the connectivity between proteins within a complex remains a major ...
Mihaela E Sardiu, Joshua M Gilmore, Michael J Carrozza, Bing Li, Jerry L Workman, Laurence Florens, Michael P Washburn   +6 more
doaj   +1 more source

Epitope mapping using mRNA display and a unidirectional nested deletion library [PDF]

, 2005
In vitro selection targeting an anti-polyhistidine monoclonal antibody was performed using mRNA display with a random, unconstrained 27-mer peptide library.
Ja, William W., Olsen, Brett N., Roberts, Richard W.   +2 more
core   +1 more source

Conservation of binding properties in protein models

Computational and Structural Biotechnology Journal, 2021
We study the models submitted to round 12 of the Critical Assessment of protein Structure Prediction (CASP) experiment to assess how well the binding properties are conserved when the X-ray structures of the target proteins are replaced by their models ...
Megan Egbert, Kathryn A. Porter, Usman Ghani, Sergei Kotelnikov, Thu Nguyen, Ryota Ashizawa, Dima Kozakov, Sandor Vajda   +7 more
doaj   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews
AbstractProtein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
openaire   +3 more sources