Results 31 to 40 of about 292,859 (260)

The use of machine learning in facilitating antibiotic discovery: A narrative review

Journal of Clinical Sciences
Antimicrobial resistance (AMR) poses a growing global threat, diminishing the effectiveness of existing antibiotics and demanding innovative solutions for new drug discovery.
Vaishnavi H. Mishra, Saransh S. Mishra, Neha K. Jaiswal, Nancy S. Nair, Mrunali S. Tarale   +4 more
doaj   +1 more source

Network Pharmacology-integrated Molecular Modeling Analysis of Momordica Charantia Fruit Neuroprotective Phytocompounds against Parkinson’s Disease

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine
BACKGROUND: In this study, we explored the potential neuroprotective effects of Momordica charantia or bitter gourd, a widely used herbal medicine recognized for its diverse therapeutic properties.
Brianne M. Austria, Alexander Carlo S. Castro, John Sylvester B. Nas   +2 more
doaj   +1 more source

Mapping Soluble Guanylyl Cyclase and Protein Disulfide Isomerase Regions of Interaction.

PLoS ONE, 2015
Soluble guanylyl cyclase (sGC) is a heterodimeric nitric oxide (NO) receptor that produces cyclic GMP. This signaling mechanism is a key component in the cardiovascular system.
Erin J Heckler, Vladyslav Kholodovych, Mohit Jain, Tong Liu, Hong Li, Annie Beuve   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Differential network biology

Molecular Systems Biology, 2012
Protein and genetic interaction maps can reveal the overall physical and functional landscape of a biological system. To date, these interaction maps have typically been generated under a single condition, even though biological systems undergo ...
Trey Ideker, Nevan J Krogan
doaj   +1 more source

Cost-Effective Mapping of Genetic Interactions in Mammalian Cells

Frontiers in Genetics, 2021
Comprehensive maps of genetic interactions in mammalian cells are daunting to construct because of the large number of potential interactions, ~ 2 × 108 for protein coding genes. We previously used co-inheritance of distant genes from published radiation
Arshad H. Khan, Desmond J. Smith
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers

Nature Communications, 2016
The AAA+ ATPase p97 is an essential hexameric protein with multiple protein interaction partners and cellular functions. Here, the authors use interaction mapping to examine partner proteins of this large complex, and assess the effects of these proteins
Anup Arumughan, Yvette Roske, Carolin Barth, Laura Lleras Forero, Kenny Bravo-Rodriguez, Alexandra Redel, Simona Kostova, Erik McShane, Robert Opitz, Katja Faelber, Kirstin Rau, Thorsten Mielke, Oliver Daumke, Matthias Selbach, Elsa Sanchez-Garcia, Oliver Rocks, Daniela Panáková, Udo Heinemann, Erich E. Wanker   +18 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
openaire   +2 more sources