Results 31 to 40 of about 267,218 (263)
Conservation of binding properties in protein models
Computational and Structural Biotechnology Journal, 2021 We study the models submitted to round 12 of the Critical Assessment of protein Structure Prediction (CASP) experiment to assess how well the binding properties are conserved when the X-ray structures of the target proteins are replaced by their models ...
Megan Egbert +7 more
doaj +1 more source
Drosophila Protein interaction Map (DPiM) [PDF]
Fly, 2012 Proteins perform essential cellular functions as part of protein complexes, often in conjunction with RNA, DNA, metabolites and other small molecules. The genome encodes thousands of proteins but not all of them are expressed in every cell type; and expressed proteins are not active at all times.
Guruharsha, K.G. +6 more
openaire +4 more sources
The use of machine learning in facilitating antibiotic discovery: A narrative review
Journal of Clinical SciencesAntimicrobial resistance (AMR) poses a growing global threat, diminishing the effectiveness of existing antibiotics and demanding innovative solutions for new drug discovery.
Vaishnavi H. Mishra +4 more
doaj +1 more source
Mapping Soluble Guanylyl Cyclase and Protein Disulfide Isomerase Regions of Interaction.
PLoS ONE, 2015 Soluble guanylyl cyclase (sGC) is a heterodimeric nitric oxide (NO) receptor that produces cyclic GMP. This signaling mechanism is a key component in the cardiovascular system.
Erin J Heckler +5 more
doaj +1 more source
Cost-Effective Mapping of Genetic Interactions in Mammalian Cells
Frontiers in Genetics, 2021 Comprehensive maps of genetic interactions in mammalian cells are daunting to construct because of the large number of potential interactions, ~ 2 × 108 for protein coding genes. We previously used co-inheritance of distant genes from published radiation
Arshad H. Khan, Desmond J. Smith
doaj +1 more source
Molecular Systems Biology, 2012 Protein and genetic interaction maps can reveal the overall physical and functional landscape of a biological system. To date, these interaction maps have typically been generated under a single condition, even though biological systems undergo ...
Trey Ideker, Nevan J Krogan
doaj +1 more source
Nature Communications, 2016 The AAA+ ATPase p97 is an essential hexameric protein with multiple protein interaction partners and cellular functions. Here, the authors use interaction mapping to examine partner proteins of this large complex, and assess the effects of these proteins
Anup Arumughan +18 more
doaj +1 more source
Pooled‐matrix protein interaction screens using Barcode Fusion Genetics
Molecular Systems Biology, 2016 High‐throughput binary protein interaction mapping is continuing to extend our understanding of cellular function and disease mechanisms. However, we remain one or two orders of magnitude away from a complete interaction map for humans and other major ...
Nozomu Yachie +32 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris +24 more
wiley +1 more source
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source