Results 1 to 10 of about 8,544,817 (263)

Protein-protein interaction based on pairwise similarity

BMC Bioinformatics, 2009
Background Protein-protein interaction (PPI) is essential to most biological processes. Abnormal interactions may have implications in a number of neurological syndromes.
Zaki Nazar, Lazarova-Molnar Sanja, El-Hajj Wassim, Campbell Piers   +3 more
doaj   +1 more source

Protein-protein Interaction Reveals Synergistic Discrimination of Cancer Phenotype

Cancer Informatics, 2010
Cancer is a disease associated with the deregulation of multiple gene networks. Microarray data has permitted researchers to identify gene panel markers for diagnosis or prognosis of cancer but these are not sufficient to make specific mechanistic ...
Jianghui Xiong, Juan Liu, Simon Rayner, Yinghui Li, Shanguang Chen   +4 more
doaj  

Protein docking prediction using predicted protein-protein interface

BMC Bioinformatics, 2012
Background Many important cellular processes are carried out by protein complexes. To provide physical pictures of interacting proteins, many computational protein-protein prediction methods have been developed in the past. However, it is still difficult
Li Bin, Kihara Daisuke
doaj   +1 more source

Unified Alignment of Protein-Protein Interaction Networks

Scientific Reports, 2017
Paralleling the increasing availability of protein-protein interaction (PPI) network data, several network alignment methods have been proposed. Network alignments have been used to uncover functionally conserved network parts and to transfer annotations.
Noël Malod-Dognin, Kristina Ban, Nataša Pržulj   +2 more
doaj   +1 more source

Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space

eLife
Fibroblast growth factor 2 (FGF2) exits cells by direct translocation across the plasma membrane, a type I pathway of unconventional protein secretion. This process is initiated by phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2)-dependent formation of ...
Fabio Lolicato, Julia P Steringer, Roberto Saleppico, Daniel Beyer, Jaime Fernandez-Sobaberas, Sebastian Unger, Steffen Klein, Petra Riegerová, Sabine Wegehingel, Hans-Michael Müller, Xiao J Schmitt, Shreyas Kaptan, Christian Freund, Martin Hof, Radek Šachl, Petr Chlanda, Ilpo Vattulainen, Walter Nickel   +17 more
doaj   +1 more source

A protein-protein interaction dictates Borrelial infectivity

Scientific Reports, 2017
Two Borrelia burgdorferi interacting proteins, BB0238 and BB0323, play distinct roles in pathogen biology and infectivity although a significance of their interaction remained enigmatic.
Meghna Thakur, Kavita Sharma, Kinlin Chao, Alexis A. Smith, Osnat Herzberg, Utpal Pal   +5 more
doaj   +1 more source

Towards the prediction of protein interaction partners using physical docking

Molecular Systems Biology, 2011
Deciphering the whole network of protein interactions for a given proteome (‘interactome’) is the goal of many experimental and computational efforts in Systems Biology.
Mark Nicholas Wass, Gloria Fuentes, Carles Pons, Florencio Pazos, Alfonso Valencia   +4 more
doaj   +1 more source

HMNPPID—human malignant neoplasm protein–protein interaction database

Human Genomics, 2019
Background Protein–protein interaction (PPI) information extraction from biomedical literature helps unveil the molecular mechanisms of biological processes.
Qingqing Li, Zhihao Yang, Zhehuan Zhao, Ling Luo, Zhiheng Li, Lei Wang, Yin Zhang, Hongfei Lin, Jian Wang, Yijia Zhang   +9 more
doaj   +1 more source

Characterization of Protein Complexes and Subcomplexes in Protein-Protein Interaction Databases

Biochemistry Research International, 2015
The identification and characterization of protein complexes implicated in protein-protein interaction data are crucial to the understanding of the molecular events under normal and abnormal physiological conditions.
Nazar Zaki, Elfadil A. Mohamed, Antonio Mora   +2 more
doaj   +1 more source

Optical Detection of CoV-SARS‑2 Viral Proteins to Sub-Picomolar Concentrations

ACS Omega, 2021
Tamsyn Stanborough, Fiona M. Given, Barbara Koch, Campbell R. Sheen, André Buzas Stowers-Hull, Mark R. Waterland, Deborah L. Crittenden   +6 more
doaj   +1 more source