Results 1 to 10 of about 3,273,634 (133)
Molecules, 2023 The growing applications of peptide-based therapeutics require the development of efficient protocols from the perspective of an industrial scale-up. T3P® (cyclic propylphosphonic anhydride) promotes amidation in the solution-phase through a biomimetic ...
Alexia Mattellone +7 more
doaj +1 more source
Identification of photocrosslinking peptide ligands by mRNA display
Communications Chemistry, 2023 Photoaffinity labelling is a promising method for studying protein-ligand interactions. However, obtaining a specific, efficient crosslinker can require significant optimisation.
Yuteng Wu +5 more
doaj +1 more source
Comparing human–Salmonella with plant–Salmonella protein–protein interaction predictions [PDF]
Frontiers in Microbiology, 2015 Salmonellosis is the most frequent foodborne disease worldwide and can be transmitted to humans by a variety of routes, especially via animal and plant products. Salmonella bacteria are believed to use not only animal and human but also plant hosts despite their evolutionary distance. This raises the question if Salmonella employs similar mechanisms in
Sylvia eSchleker +3 more
openaire +4 more sources
Developing methods to study conformational changes in RNA crystals using a photocaged ligand
Frontiers in Molecular Biosciences, 2022 Crystallographic observation of structural changes in real time requires that those changes be uniform both spatially and temporally. A primary challenge with time-resolved ligand-mixing diffraction experiments is asynchrony caused by variable factors ...
Hyun Kyung Lee +8 more
doaj +1 more source
Fitting a geometric graph to a protein-protein interaction network [PDF]
, 2008 Finding a good network null model for protein-protein interaction (PPI) networks is a fundamental issue. Such a model would provide insights into the interplay between network structure and biological function as well as into evolution.
Barabási +46 more
core +3 more sources
Frontiers in Immunology, 2021 Kawasaki disease (KD) is a febrile disease of childhood characterized by systemic vasculitis that can lead to coronary artery lesions (CAL). This was a prospective cohort study to determine the levels of the pentraxin 3 (PTX3), soluble CD24-Subtype ...
Toshiyuki Kitoh +11 more
doaj +1 more source
Visualizing RNA conformational and architectural heterogeneity in solution
Nature Communications, 2023 RNA conformational heterogeneity is important to diverse functions. Here, the authors use AFM to directly visualize individual RNA molecules that are in various conformational states under near physiological solution conditions for the first time.
Jienyu Ding +12 more
doaj +1 more source
The Landscape of Virus-Host Protein–Protein Interaction Databases
Frontiers in Microbiology, 2022 Knowledge of virus-host interactomes has advanced exponentially in the last decade by the use of high-throughput screening technologies to obtain a more comprehensive landscape of virus-host protein–protein interactions.
Gabriel Valiente
doaj +1 more source
Biochemistry and Biophysics Reports, 2020 Angiotensin II (Ang II) type 2 receptor (AT2R) is one of the major components of the renin-angiotensin-aldosterone system. Nevertheless, the physiological role is not well defined compared to the understanding of the Ang II type 1 receptor (AT1R), which ...
Keita Soda +3 more
doaj +1 more source
Calcium in the Backstage of Malaria Parasite Biology
Frontiers in Cellular and Infection Microbiology, 2021 The calcium ion (Ca2+) is a ubiquitous second messenger involved in key biological processes in prokaryotes and eukaryotes. In Plasmodium species, Ca2+ signaling plays a central role in the parasite life cycle.
Lucas Silva de Oliveira +8 more
doaj +1 more source