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Interactomes by mass spectrometry
Nature Methods, 2012Two different mass spectrometry–based approaches are applied to analyze protein complexes on a global scale.
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Deciphering the melanoma interactome
Journal of Cutaneous Pathology, 2008Late‐stage malignant melanoma continues to pose a significant therapeutic challenge, despite numerous recent advances in our understanding of the molecular and genetic pathways leading to tumor development and progression. Dr Scott McNutt was among the first researchers to employ the cutting edge technology, electron microscopy, to the study of ...
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2004
Proteine liegen in Zellen als Multiproteinkomplexe vor, die entscheidend für die Funktionen von Proteinen und das Verhalten der Zellen sind. Wir haben eine Proteomics-Technologie entwickelt, mit der Proteinkomplexe in nativer Form analysiert werden können: die zweidimensionale Blau-Native-/SDS-Gelelektrophorese von Zelllysaten.
Schamel, W., Camacho-Carvajal, M.
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Proteine liegen in Zellen als Multiproteinkomplexe vor, die entscheidend für die Funktionen von Proteinen und das Verhalten der Zellen sind. Wir haben eine Proteomics-Technologie entwickelt, mit der Proteinkomplexe in nativer Form analysiert werden können: die zweidimensionale Blau-Native-/SDS-Gelelektrophorese von Zelllysaten.
Schamel, W., Camacho-Carvajal, M.
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ACS Chemical Biology, 2011
The mitogen-activated protein kinase (MAPK) signaling network is integrated into most, if not all, defined homeostatic and regulatory responses of eukaryotic cells. A systematic experimental and computational approach has been used to identify more than 2,000 protein interactions related to functions and regulation of the MAPK signaling network.
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The mitogen-activated protein kinase (MAPK) signaling network is integrated into most, if not all, defined homeostatic and regulatory responses of eukaryotic cells. A systematic experimental and computational approach has been used to identify more than 2,000 protein interactions related to functions and regulation of the MAPK signaling network.
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Analyzing IDPs in Interactomes
2020Intrinsically disordered proteins (IDPs) and regions (IDRs) are commonly found in all proteomes analyzed so far. These proteins/regions are subject to numerous posttranslational modifications (PTMs) and alternative splicing, are involved in a wide range of cellular functions, and often facilitate protein-protein interactions (PPIs).
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Tau Interactome Maps Synaptic and Mitochondrial Processes Associated With Neurodegeneration
Cell, 2022Danielle L Swaney +2 more
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Using Interactome Big Data to Crack Genetic Mysteries and Enhance Future Crop Breeding
Molecular Plant, 2021Hongwei Zhang, Lin Li, Leiming Wu
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Dual Proteome-Scale Networks Reveal Cell-Specific Remodeling of the Human Interactome
Cell, 2021José Navarrete-Perea +2 more
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The Oral Host–Microbial Interactome: An Ecological Chronometer of Health?
Trends in Microbiology, 2021Anna Edlund +2 more
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Illuminating the Dark Protein-Protein Interactome
Cell Reports Methods, 2022Xiao-Dong Su +2 more
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