Results 1 to 10 of about 53,983 (298)
Genomic data integration systematically biases interactome mapping. [PDF]
PLoS Computational Biology, 2018 Elucidating the complete network of protein-protein interactions, or interactome, is a fundamental goal of the post-genomic era, yet existing interactome maps are far from complete.
Michael A Skinnider +2 more
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Fusion-positive rhabdomyosarcoma oncofusions share a common interactome [PDF]
Nature CommunicationsFusion-positive rhabdomyosarcoma (FP-RMS) arises from at least seven distinct oncofusions sharing a common PAX3/7 N-terminal DNA-binding domain fused to divergent C-terminal partners. How different oncofusions produce the same cancer was unknown. Here we
S. P. Zimmerman +15 more
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Network Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class) [PDF]
BiomoleculesThis study presents an in-depth analysis of an interactome comprising approximately 1033 nodes, focusing on its topology, reliability, and functional implications, with particular attention to the small mitochondrial proteins of the Humanin family and ...
Mohd Shahzaib +4 more
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Letter to the Editor – Oral microbiota, health and cancer: the dual face of the same coin in the field of the host-microbe interactome [PDF]
World Cancer Research Journal, 2021 Dear Editor In recent years, within the extensive research regarding human microbiota and chronic diseases, new medical and laboratory technologies have played a crucial role in understanding more complex biological pathways between human cells and ...
V. Garau +4 more
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Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network: a systems level model of adaptation. [PDF]
PLoS Computational Biology, 2011 Network analysis became a powerful tool giving new insights to the understanding of cellular behavior. Heat shock, the archetype of stress responses, is a well-characterized and simple model of cellular dynamics. S.
Ágoston Mihalik, Peter Csermely
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Frontiers in Molecular Neuroscience, 2022 Despite the knowledge that mutation, multiplication, and anomalous function of α-synuclein cause progressive transformation of α-synuclein monomers into toxic amyloid fibrils in neurodegenerative diseases, the understanding of canonical signaling ...
Sharad Kumar Suthar +2 more
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The Hepatitis B Virus Interactome: A Comprehensive Overview
Frontiers in Microbiology, 2021 Despite the availability of a prophylactic vaccine, chronic hepatitis B (CHB) caused by the hepatitis B virus (HBV) is a major health problem affecting an estimated 292 million people globally.
Ellen Van Damme +5 more
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Tick Importin-α Is Implicated in the Interactome and Regulome of the Cofactor Subolesin
Pathogens, 2021 Ticks and tick-borne diseases (TBDs) represent a burden for human and animal health worldwide. Currently, vaccines constitute the safest and most effective approach to control ticks and TBDs.
Sara Artigas-Jerónimo +13 more
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Frontiers in Oncology, 2022 Patients who develop testicular germ cell tumours (TGCT) are at higher risk to be subfertile than the general population. The conditions are believed to originate during foetal life, however, the mechanisms behind a common aetiology of TGCT and male ...
Joshua Burton +5 more
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Antioxidants, 2021 Age-related macular degeneration (AMD) is a complex degenerative disease of the retina with multiple risk-modifying factors, including aging, genetics, and lifestyle choices.
David A. Merle +7 more
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