Results 1 to 10 of about 63,382 (353)
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration
Cell, 2022 SUMMARY Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies. To dissect the underlying mechanisms, we combined an engineered ascorbic acid peroxidase (APEX) approach with quantitative affinity purification mass ...
Tara E Tracy +2 more
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Genomic data integration systematically biases interactome mapping. [PDF]
PLoS Computational Biology, 2018 Elucidating the complete network of protein-protein interactions, or interactome, is a fundamental goal of the post-genomic era, yet existing interactome maps are far from complete.
Michael A Skinnider +2 more
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Structural coverage of the human interactome
Briefings in Bioinformatics, 2023 Complex biological processes in cells are embedded in the interactome, representing the complete set of protein-protein interactions. Mapping and analyzing the protein structures are essential to fully comprehending these processes’ molecular details ...
Nurcan Tuncbag +2 more
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Illuminating the dark protein-protein interactome
Cell Reports Methods, 2022 Summary In living systems, a complex network of protein-protein interactions (PPIs) underlies most biochemical events. The human protein-protein interactome has been surveyed using yeast two-hybrid (Y2H)- and mass spectrometry (MS)-based approaches such ...
Mehdi Sharifi Tabar +2 more
exaly +2 more sources
Human Long Noncoding RNA Interactome: Detection, Characterization and Function
International Journal of Molecular Sciences, 2020 The application of a new generation of sequencing techniques has revealed that most of the genome has already been transcribed. However, only a small part of the genome codes proteins.
Marta Elżbieta Kasprzyk +1 more
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Cell Reports, 2018 Summary R-loops comprise an RNA/DNA hybrid and displaced single-stranded DNA. They play important biological roles and are implicated in pathology. Even so, proteins recognizing these structures are largely undefined. Using affinity purification with the
Agnese Cristini, Natalia Gromak
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Letter to the Editor – Oral microbiota, health and cancer: the dual face of the same coin in the field of the host-microbe interactome [PDF]
World Cancer Research Journal, 2021 Dear Editor In recent years, within the extensive research regarding human microbiota and chronic diseases, new medical and laboratory technologies have played a crucial role in understanding more complex biological pathways between human cells and ...
V. Garau +4 more
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Affinity‐Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6‐PP‐InsP5‐Binding Proteins in Plants [PDF]
Advanced ScienceInositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in ...
Kevin Ritter +10 more
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Frontiers in Molecular Neuroscience, 2022 Despite the knowledge that mutation, multiplication, and anomalous function of α-synuclein cause progressive transformation of α-synuclein monomers into toxic amyloid fibrils in neurodegenerative diseases, the understanding of canonical signaling ...
Sharad Kumar Suthar +2 more
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Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network: a systems level model of adaptation. [PDF]
PLoS Computational Biology, 2011 Network analysis became a powerful tool giving new insights to the understanding of cellular behavior. Heat shock, the archetype of stress responses, is a well-characterized and simple model of cellular dynamics. S.
Ágoston Mihalik, Peter Csermely
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