Results 31 to 40 of about 63,382 (353)

Curating the innate immunity interactome [PDF]

, 2010
peer-reviewedBackground: The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks.
Laird, Matthew R, Anastasia Sribnaia, Winsor, Geoffrey L., Lynn, David J, Giselle Ring, Foroushani, Amir K., Laird, Matthew R., Que, Jaimmie, Geoffrey L Winsor, Robert EW Hancock, Sribnaia, Anastasia, Hancock, Robert E.W., Ring, Giselle, Melissa Yau, Fiona SL Brinkman, Calvin Chan, Jaimmie Que, David J Lynn, Brinkman, Fiona S. L., Naseer, Misbah, Matthew R Laird, Yau, Melissa, Lo, Raymond, Raymond Lo, Chan, Calvin, Wee, Kathleen, Winsor, Geoffrey L, Breuer, Karin, Kathleen Wee, Amir K Foroushani, Hancock, R. E. W. (Robert E. W.), Brinkman, Fiona S., Misbah Naseer, Karin Breuer, Lynn, David J.   +34 more
core   +1 more source

Characterization of Cystatin B Interactome in Saliva from Healthy Elderly and Alzheimer’s Disease Patients

Life, 2023
Cystatin B is a small, multifunctional protein involved in the regulation of inflammation, innate immune response, and neuronal protection and found highly abundant in the brains of patients with Alzheimer’s disease (AD). Recently, our study demonstrated
Cristina Contini, Simone Serrao, Barbara Manconi, Alessandra Olianas, Federica Iavarone, Giulia Guadalupi, Irene Messana, Massimo Castagnola, Carlo Masullo, Alessandra Bizzarro, Christoph W. Turck, Giuseppina Maccarrone, Tiziana Cabras   +12 more
doaj   +1 more source

In vivo RNA interactome profiling reveals 3’UTR-processed small RNA targeting a central regulatory hub

Nature Communications, 2023
Small noncoding RNAs (sRNAs) are crucial regulators of gene expression in bacteria. Acting in concert with major RNA chaperones such as Hfq or ProQ, sRNAs base-pair with multiple target mRNAs and form large RNA-RNA interaction networks. To systematically
Fang Liu, Ziying Chen, Shuo Zhang, Kejing Wu, Cheng Bei, Chuan Wang, Yanjie Chao   +6 more
semanticscholar   +1 more source

Deep interactome learning for de novo drug design

, 2023
De novo drug design aims to generate molecules from scratch that possess specific chemical and pharmacological properties. We present a computational approach utilizing interactome-based deep learning for ligand- and structure-based generation of drug ...
Leandro, Cotos Muñoz, Mattis, Hilleke, Jann, Ledergerber, Carl C. G., Schiebroek, Jan A., Hiss, Daniel, Merk, Clemens, Isert, Dorota, Focht, Kenneth, Atz, Maria , Håkansson, Michael, Iff, Uwe, Grether, David F., Nippa, Gisbert, Schneider, Petra, Schneider, Bernd, Kuhn   +15 more
core   +1 more source

Chemometric Models of Differential Amino Acids at the Na_vα and Na_vβ Interface of Mammalian Sodium Channel Isoforms

Molecules, 2020
(1) Background: voltage-gated sodium channels (Navs) are integral membrane proteins that allow the sodium ion flux into the excitable cells and initiate the action potential.
Fernando Villa-Diaz, Susana Lopez-Nunez, Jordan E. Ruiz-Castelan, Eduardo Marcos Salinas-Stefanon, Thomas Scior   +4 more
doaj   +1 more source

Physiological Benefits of Dietary Lysophospholipid Supplementation in a Marine Fish Model: Deep Analyses of Modes of Action

Animals, 2023
Given the hydrophilic structure of lysophospholipids (LPLs), their dietary inclusion translates into a better emulsifying capacity of the dietary components.
Antoni Ibarz, Ignasi Sanahuja, Waldo G. Nuez-Ortín, Laura Martínez-Rubio, Laura Fernández-Alacid   +4 more
doaj   +1 more source

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Molecules and Cells, 2023
SUMMARY Dynamic changes in protein-protein interaction (PPI) networks underlie all physiological cellular functions and drive devastating human diseases. Profiling PPI networks can, therefore, provide critical insight into disease mechanisms and identify
Martin G. Golkowski, Andrea Lius, Tanmay R. Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J Maly, Shao-En Ong   +6 more
semanticscholar   +1 more source

A Proteome-Scale Map of the Human Interactome Network

Cell, 2014
Thomas Rolland, Murat Tasan, Benoit Charloteaux   +2 more
exaly   +2 more sources

Functional integrative levels in the human interactome recapitulate organ organization.

PLoS ONE, 2011
Interactome networks represent sets of possible physical interactions between proteins. They lack spatio-temporal information by construction. However, the specialized functions of the differentiated cell types which are assembled into tissues or organs ...
Ouissem Souiai, Emmanuelle Becker, Carlos Prieto, Alia Benkahla, Javier De las Rivas, Christine Brun   +5 more
doaj   +1 more source

Multiple Regionalized Genes and Their Putative Networks in the Interpeduncular Nucleus Suggest Complex Mechanisms of Neuron Development and Axon Guidance

Frontiers in Neuroanatomy, 2021
The interpeduncular nucleus (IPN) is a highly conserved limbic structure in the vertebrate brain, located in the isthmus and rhombomere 1. It is formed by various populations that migrate from different sites to the distinct domains within the IPN: the ...
Isabel M. García-Guillén, Antonia Alonso, Luis Puelles, Faustino Marín, Pilar Aroca   +4 more
doaj   +1 more source