Results 31 to 40 of about 79,704 (286)
Rapid, optimized interactomic screening [PDF]
Nature Methods, 2015 We must reliably map the interactomes of cellular macromolecular complexes in order to fully explore and understand biological systems. However, there are no methods to accurately predict how to capture a given macromolecular complex with its physiological binding partners.
Zhanna Hakhverdyan +14 more
openaire +3 more sources
Medicina, 2019 Background and Objectives: The defects in the CLDN16 gene are a cause of primary hypomagnesemia (FHHNC), which is characterized by massive renal magnesium wasting, resulting in nephrocalcinosis and renal failure.
Erasmia Rouka +4 more
doaj +1 more source
A human MAP kinase interactome. [PDF]
, 2010 Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other ...
A Friedman +51 more
core +3 more sources
Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways [PDF]
, 2016 Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS are being identified, but how these genetic defects lead to motor neuron degeneration and ...
Anink, Jasper J. +17 more
core +3 more sources
Interactome INSIDER: a structural interactome browser for genomic studies [PDF]
Nature Methods, 2018 We present Interactome INSIDER, a tool to link genomic variant information with structural protein-protein interactomes. Underlying this tool is the application of machine learning to predict protein interaction interfaces for 185,957 protein interactions with previously unresolved interfaces in human and seven model organisms, including the entire ...
Michael J Meyer +7 more
openaire +2 more sources
Frontiers in Molecular Biosciences, 2022 At the heart of the cellular machinery through the regulation of cellular functions, protein–protein interactions (PPIs) have a significant role. PPIs can be analyzed with network approaches.
Vivian Robin +5 more
doaj +1 more source
A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk. [PDF]
, 2020 BackgroundTumors comprise a complex microenvironment of interacting malignant and stromal cell types. Much of our understanding of the tumor microenvironment comes from in vitro studies isolating the interactions between malignant cells and a single ...
Azizi, Armon +19 more
core +4 more sources
The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation [PDF]
, 2015 Autophagy is a self-degradative physiological process by which the cell removes worn-out or damaged components. Constant at basal level it may become highly active in response to cellular stress. The type 2 transglutaminase (TG2), which accumulates under
Belkin +61 more
core +2 more sources
BAG3 Proteomic Signature under Proteostasis Stress
Cells, 2020 The multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3) represents a key player in the quality control of the cellular proteostasis network.
Christof Hiebel +8 more
doaj +1 more source
The SARS-coronavirus-host interactome [PDF]
, 2011 Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to ...
Brunn, Albrecht von +27 more
core +1 more source