Results 31 to 40 of about 38,917 (265)
Frontiers in Molecular Biosciences, 2022 At the heart of the cellular machinery through the regulation of cellular functions, protein–protein interactions (PPIs) have a significant role. PPIs can be analyzed with network approaches.
Vivian Robin +5 more
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BAG3 Proteomic Signature under Proteostasis Stress
Cells, 2020 The multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3) represents a key player in the quality control of the cellular proteostasis network.
Christof Hiebel +8 more
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Diabetologia, 2005 Islet antigen-2 (IA-2), a major autoantigen in type 1 diabetes, is an enzymatically inactive member of the transmembrane protein tyrosine phosphatase (PTP) family. IA-2 is located in dense-core secretory vesicles and is involved in the regulation of insulin secretion.
Notkins, A. L. +4 more
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Recent Advances in Chemical Biology Using Benzophenones and Diazirines as Radical Precursors
Molecules, 2020 The use of light-activated chemical probes to study biological interactions was first discovered in the 1960s, and has since found many applications in studying diseases and gaining deeper insight into various cellular mechanisms involving protein ...
Muhammad Murtaza Hassan +1 more
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FEBS Letters, 2005 A long‐term goal of the field of interactome modeling is to understand how global and local properties of complex macromolecular networks impact on observable biological properties, and how changes in such properties can lead to human diseases. The information available at this stage of development of the field provides strong evidence for the ...
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Biology, 2020 Mitochondria are highly dynamic and regulated organelles implicated in a variety of important functions in the cell, including energy production, fatty acid metabolism, iron homeostasis, programmed cell death, and cell signaling. Changes in mitochondrial
Loredana Moro
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Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers
eLife, 2017 The amyloid β peptide (Aβ) is a key player in the etiology of Alzheimer disease (AD), yet a systematic investigation of its molecular interactions has not been reported. Here we identified by quantitative mass spectrometry proteins in human brain extract
Hansen Wang +12 more
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Collagen Structure-Function Mapping Informs Applications for Regenerative Medicine
Bioengineering, 2020 Type I collagen, the predominant protein of vertebrates, assembles into fibrils that orchestrate the form and function of bone, tendon, skin, and other tissues.
James D. San Antonio +3 more
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Modelling the Yeast Interactome [PDF]
Scientific Reports, 2014 The topology behind biological interaction networks has been studied for over a decade. Yet, there is no definite agreement on the theoretical models which best describe protein-protein interaction (PPI) networks. Such models are critical to quantifying the significance of any empirical observation regarding those networks.
V. Janjic, R. Sharan, and N. Przulj
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Communications BiologyWhy cancer cells disproportionately accumulate polyubiquitinated proteotoxic proteins despite high proteasomal activity is an outstanding question. While mis-regulated ubiquitination is a contributing factor, here we show that a structurally-perturbed ...
Rangapriya Sundararajan +5 more
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