Results 31 to 40 of about 53,983 (298)

ANIA:ANnotation and Integrated Analysis of the 14-3-3 interactome [PDF]

, 2014
The dimeric 14-3-3 proteins dock onto pairs of phosphorylated Ser and Thr residues on hundreds of proteins, and thereby regulate many events in mammalian cells.
Murugesan, Gavuthami, Mackintosh, Carol; id_orcid, Hoxhaj, Gerta, Toth, Rachel, Tinti, Michele, Madeira, Fabio   +5 more
core   +1 more source

Functional Evolution of Subolesin/Akirin

Frontiers in Physiology, 2018
The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes.
Sara Artigas-Jerónimo, Margarita Villar, Alejandro Cabezas-Cruz, James J. Valdés, James J. Valdés, James J. Valdés, Agustín Estrada-Peña, Pilar Alberdi, José de la Fuente, José de la Fuente   +9 more
doaj   +1 more source

There is no human interactome [PDF]

Genome Biology, 2016
Protein complexes are dynamic. A new analysis of two quantitative proteomic datasets reveals cell type-specific changes in the stoichiometry of complexes, which often involve paralog switching.
openaire   +2 more sources

Precise Temporal Profiling of Signaling Complexes in Primary Cells Using SWATH Mass Spectrometry

Cell Reports, 2017
Spatiotemporal organization of protein interactions in cell signaling is a fundamental process that drives cellular functions. Given differential protein expression across tissues and developmental stages, the architecture and dynamics of signaling ...
Etienne Caron, Romain Roncagalli, Takeshi Hase, Witold E. Wolski, Meena Choi, Marisa G. Menoita, Stephane Durand, Antonio García-Blesa, Ivo Fierro-Monti, Tatjana Sajic, Moritz Heusel, Tobias Weiss, Marie Malissen, Ralph Schlapbach, Ben C. Collins, Samik Ghosh, Hiroaki Kitano, Ruedi Aebersold, Bernard Malissen, Matthias Gstaiger   +19 more
doaj   +1 more source

Biophysical and Biochemical Characterization of Nascent Polypeptide-Associated Complex of Picrophilus torridus and Elucidation of Its Interacting Partners

Frontiers in Microbiology, 2020
Nascent polypeptide-associated complex (NAC) is a ribosome-associated molecular chaperone which is present only in archaea and eukaryotes. The primary function of NAC is to shield the newly synthesized polypeptide chains from inappropriate interactions ...
Neelja Singhal, Archana Sharma, Shobha Kumari, Anjali Garg, Ruchica Rai, Nirpendra Singh, Manish Kumar, Manisha Goel   +7 more
doaj   +1 more source

Identification of Partner Proteins of the Algae Klebsormidium nitens NO Synthases: Toward a Better Understanding of NO Signaling in Eukaryotic Photosynthetic Organisms

Frontiers in Plant Science, 2021
In animals, NO is synthesized from L-arginine by three isoforms of nitric oxide synthase (NOS) enzyme. NO production and effects have also been reported in plants but the identification of its sources, especially the enzymatic ones, remains one of the ...
Pauline Chatelain, Jeremy Astier, David Wendehenne, Claire Rosnoblet, Sylvain Jeandroz   +4 more
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Bruno A, Conti M, Dolcetti E, Azzolini F, Borrelli A, Fantozzi R, Stampanoni Bassi M, Galifi G, Maccarrone G, Montaguti L, Cervigni M, Pozzo MD, Furlan R, Finardi A, Marfia GA, Salvetti M, Conte A, Buttari F, Centonze D, Gilio L.   +19 more
europepmc   +2 more sources

Production of T. gondii transgenic strains to characterize the tubulin cofactor B interactome [PDF]

, 2021
Projeto "Characterization of the T. gondii TBCB interactome" (UID/CVT/00276/2019)Mestrado em Tecnologias Moleculares em SaúdeToxoplasma gondii é um parasita intracelular obrigatório que infeta a maioria dos animais, apresentando uma distribuição mundial.
Veva, Ana Madalena Martins
core  

In-Depth Bioinformatic Study of the CLDN16 Gene and Protein: Prediction of Subcellular Localization to Mitochondria

Medicina, 2019
Background and Objectives: The defects in the CLDN16 gene are a cause of primary hypomagnesemia (FHHNC), which is characterized by massive renal magnesium wasting, resulting in nephrocalcinosis and renal failure.
Erasmia Rouka, Vassilios Liakopoulos, Konstantinos I. Gourgoulianis, Chrissi Hatzoglou, Sotirios G. Zarogiannis   +4 more
doaj   +1 more source

Interactome INSIDER: a structural interactome browser for genomic studies [PDF]

Nature Methods, 2018
We present Interactome INSIDER, a tool to link genomic variant information with structural protein-protein interactomes. Underlying this tool is the application of machine learning to predict protein interaction interfaces for 185,957 protein interactions with previously unresolved interfaces in human and seven model organisms, including the entire ...
Michael J Meyer, Juan Felipe Beltrán, Siqi Liang, Robert Fragoza, Aaron Rumack, Jin Liang, Xiaomu Wei, Haiyuan Yu   +7 more
openaire   +2 more sources