Results 21 to 30 of about 63,382 (353)
The social and structural architecture of the yeast protein interactome
Nature, 2023 Cellular functions are mediated by protein–protein interactions, and mapping the interactome provides fundamental insights into biological systems. Affinity purification coupled to mass spectrometry is an ideal tool for such mapping, but it has been ...
André C. Michaelis +6 more
semanticscholar +1 more source
Viruses and Interactomes in Translation [PDF]
Molecular & Cellular Proteomics, 2012 A decade of high-throughput screenings for intraviral and virus-host protein-protein interactions led to the accumulation of data and to the development of theories on laws governing interactome organization for many viruses. We present here a computational analysis of intraviral protein networks (EBV, FLUAV, HCV, HSV-1, KSHV, SARS-CoV, VACV, and VZV ...
Meyniel-Schicklin, Laurène +3 more
openaire +2 more sources
Nature Biotechnology, 2022 Studying viral–host protein–protein interactions can facilitate the discovery of therapies for viral infection. We use high-throughput yeast two-hybrid experiments and mass spectrometry to generate a comprehensive SARS-CoV-2–human protein–protein ...
Yadi Zhou +22 more
semanticscholar +1 more source
EMBO reports, 2023 When scientists marry each other their chances of both finding satisfactory academic jobs diminishes. What can be done to help them fulfil their potential?
openaire +2 more sources
Computational Network Inference for Bacterial Interactomics
mSystems, 2022 Since the large-scale experimental characterization of protein–protein interactions (PPIs) is not possible for all species, several computational PPI prediction methods have been developed that harness existing data from other species.
Katherine James, Jose Muñoz-Muñoz
doaj +1 more source
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
bioRxiv, 2020 Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction ...
Edward L. Huttlin +27 more
semanticscholar +1 more source
Nucleic Acids Res., 2021 Establishing an RNA-associated interaction repository facilitates the system-level understanding of RNA functions. However, as these interactions are distributed throughout various resources, an essential prerequisite for effectively applying these data ...
Juanjuan Kang +17 more
semanticscholar +1 more source
A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology
eLife, 2022 Neuroscience currently requires the use of antibodies to study synaptic proteins, where antibody binding is used as a correlate to define the presence, plasticity, and regulation of synapses. Gephyrin is an inhibitory synaptic scaffolding protein used to
Benjamin FN Campbell +4 more
doaj +1 more source
Interactome Analysis Identifies MSMEI_3879 as a Substrate of Mycolicibacterium smegmatis ClpC1
Microbiology Spectrum, 2023 The prevalence of drug-resistant Mycobacterium tuberculosis infections has prompted extensive efforts to exploit new drug targets in this globally important pathogen.
Emmanuel C. Ogbonna +4 more
doaj +1 more source
cytoHubba: identifying hub objects and sub-networks from complex interactome
BMC Systems Biology, 2014 BackgroundNetwork is a useful way for presenting many types of biological data including protein-protein interactions, gene regulations, cellular pathways, and signal transductions. We can measure nodes by their network features to infer their importance
Chia-Hao Chin +5 more
semanticscholar +1 more source