Results 21 to 30 of about 53,983 (298)

Potential syntrophic associations in anaerobic naphthenic acids biodegrading consortia inferred with microbial interactome networks [PDF]

, 2020
Naphthenic acids (NAs) can be syntrophically metabolized by indigenous microbial communities in pristine sediments beneath oil sands tailings ponds. Syntrophy is an essential determinant of the microbial interactome, however, the interactome network in ...
Xiaofei Lv, Bin Ma, Korris Lee, Ania Ulrich
core   +1 more source

A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology

eLife, 2022
Neuroscience currently requires the use of antibodies to study synaptic proteins, where antibody binding is used as a correlate to define the presence, plasticity, and regulation of synapses. Gephyrin is an inhibitory synaptic scaffolding protein used to
Benjamin FN Campbell, Antje Dittmann, Birgit Dreier, Andreas Plückthun, Shiva K Tyagarajan   +4 more
doaj   +1 more source

Curating the innate immunity interactome [PDF]

, 2010
peer-reviewedBackground: The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks.
Laird, Matthew R, Anastasia Sribnaia, Winsor, Geoffrey L., Lynn, David J, Giselle Ring, Foroushani, Amir K., Laird, Matthew R., Que, Jaimmie, Geoffrey L Winsor, Robert EW Hancock, Sribnaia, Anastasia, Hancock, Robert E.W., Ring, Giselle, Melissa Yau, Fiona SL Brinkman, Calvin Chan, Jaimmie Que, David J Lynn, Brinkman, Fiona S. L., Naseer, Misbah, Matthew R Laird, Yau, Melissa, Lo, Raymond, Raymond Lo, Chan, Calvin, Wee, Kathleen, Winsor, Geoffrey L, Breuer, Karin, Kathleen Wee, Amir K Foroushani, Hancock, R. E. W. (Robert E. W.), Brinkman, Fiona S., Misbah Naseer, Karin Breuer, Lynn, David J.   +34 more
core   +1 more source

Interactome Analysis Identifies MSMEI_3879 as a Substrate of Mycolicibacterium smegmatis ClpC1

Microbiology Spectrum, 2023
The prevalence of drug-resistant Mycobacterium tuberculosis infections has prompted extensive efforts to exploit new drug targets in this globally important pathogen.
Emmanuel C. Ogbonna, Henry R. Anderson, Patrick C. Beardslee, Priyanka Bheemreddy, Karl R. Schmitz   +4 more
doaj   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage-Specific Vulnerabilities in Alzheimer's Disease. [PDF]

Adv Sci (Weinh)
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Böken D, Lobo PB, Wu Y, Rowe LA, Fertan E, Croft CL, Jimenez-Sanchez M, Cox D, Klenerman D.   +8 more
europepmc   +2 more sources

Characterization of Cystatin B Interactome in Saliva from Healthy Elderly and Alzheimer’s Disease Patients

Life, 2023
Cystatin B is a small, multifunctional protein involved in the regulation of inflammation, innate immune response, and neuronal protection and found highly abundant in the brains of patients with Alzheimer’s disease (AD). Recently, our study demonstrated
Cristina Contini, Simone Serrao, Barbara Manconi, Alessandra Olianas, Federica Iavarone, Giulia Guadalupi, Irene Messana, Massimo Castagnola, Carlo Masullo, Alessandra Bizzarro, Christoph W. Turck, Giuseppina Maccarrone, Tiziana Cabras   +12 more
doaj   +1 more source

Chemometric Models of Differential Amino Acids at the Na_vα and Na_vβ Interface of Mammalian Sodium Channel Isoforms

Molecules, 2020
(1) Background: voltage-gated sodium channels (Navs) are integral membrane proteins that allow the sodium ion flux into the excitable cells and initiate the action potential.
Fernando Villa-Diaz, Susana Lopez-Nunez, Jordan E. Ruiz-Castelan, Eduardo Marcos Salinas-Stefanon, Thomas Scior   +4 more
doaj   +1 more source

Physiological Benefits of Dietary Lysophospholipid Supplementation in a Marine Fish Model: Deep Analyses of Modes of Action

Animals, 2023
Given the hydrophilic structure of lysophospholipids (LPLs), their dietary inclusion translates into a better emulsifying capacity of the dietary components.
Antoni Ibarz, Ignasi Sanahuja, Waldo G. Nuez-Ortín, Laura Martínez-Rubio, Laura Fernández-Alacid   +4 more
doaj   +1 more source

Functional integrative levels in the human interactome recapitulate organ organization.

PLoS ONE, 2011
Interactome networks represent sets of possible physical interactions between proteins. They lack spatio-temporal information by construction. However, the specialized functions of the differentiated cell types which are assembled into tissues or organs ...
Ouissem Souiai, Emmanuelle Becker, Carlos Prieto, Alia Benkahla, Javier De las Rivas, Christine Brun   +5 more
doaj   +1 more source

Multiple Regionalized Genes and Their Putative Networks in the Interpeduncular Nucleus Suggest Complex Mechanisms of Neuron Development and Axon Guidance

Frontiers in Neuroanatomy, 2021
The interpeduncular nucleus (IPN) is a highly conserved limbic structure in the vertebrate brain, located in the isthmus and rhombomere 1. It is formed by various populations that migrate from different sites to the distinct domains within the IPN: the ...
Isabel M. García-Guillén, Antonia Alonso, Luis Puelles, Faustino Marín, Pilar Aroca   +4 more
doaj   +1 more source