Results 11 to 20 of about 53,983 (298)
FEBS Letters, 2005 A long‐term goal of the field of interactome modeling is to understand how global and local properties of complex macromolecular networks impact on observable biological properties, and how changes in such properties can lead to human diseases. The information available at this stage of development of the field provides strong evidence for the ...
Vidal, Marc
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Advanced Biology, 2021 AbstractT cell activation is a fine‐tuned process that involves T cell receptor and costimulation signals. To prevent undue activation of T cells, inhibitory molecules including PD‐1 (programmed death 1) are induced and function as brakes for T cell signaling.
Qi Wang +3 more
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Comparative interactomics [PDF]
FEBS Letters, 2005 The behavior, morphology and response to stimuli in biological systems are dictated by the interactions between their components. These interactions, as we observe them now, are therefore shaped by genetic variations and selective pressure. Similar to what has been achieved by comparing genome structures and protein sequences, we hope to obtain ...
CESARENI, GIOVANNI +5 more
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Deep interactome learning for de novo drug design [PDF]
, 2023 De novo drug design aims to generate molecules from scratch that possess specific chemical and pharmacological properties. We present a computational approach utilizing interactome-based deep learning for ligand- and structure-based generation of drug ...
Leandro, Cotos Muñoz +15 more
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The interactome challenge [PDF]
Journal of Cell Biology, 2015 The properties of living cells are mediated by a huge number of ever-changing interactions of their component macromolecules forming living machines; collectively, these are termed the interactome. Pathogenic alterations in interactomes mechanistically underlie diseases.
Aitchison, John D., Rout, Michael P.
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Improving the resolution of interaction maps: A middleground between high-resolution complexes and genome-wide interactomes [PDF]
, 2013 Protein-protein interactions are ubiquitous in Biology and therefore central to understand living organisms. In recent years, large-scale studies have been undertaken to describe, at least partially, protein-protein interaction maps or interactomes for a
Mora, Joan Segura
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Schizophrenia interactome: fully-labeled interactome network [PDF]
npj Schizophrenia, 2016 We recently published the schizophrenia interactome1 that showed hundreds of protein-protein interactions (PPIs) of schizophrenia-associated genes, including 504 novel PPIs. Figure 2 in that article gave an overview of how many known or novel PPIs each of the schizophrenia genes had, while the specific interactions were made available through a ...
Ganapathiraju, Madhavi +1 more
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Viruses and Interactomes in Translation [PDF]
Molecular & Cellular Proteomics, 2012 A decade of high-throughput screenings for intraviral and virus-host protein-protein interactions led to the accumulation of data and to the development of theories on laws governing interactome organization for many viruses. We present here a computational analysis of intraviral protein networks (EBV, FLUAV, HCV, HSV-1, KSHV, SARS-CoV, VACV, and VZV ...
Meyniel-Schicklin, Laurène +3 more
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EMBO Reports, 2023 When scientists marry each other their chances of both finding satisfactory academic jobs diminishes. What can be done to help them fulfil their potential?
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Computational Network Inference for Bacterial Interactomics
mSystems, 2022 Since the large-scale experimental characterization of protein–protein interactions (PPIs) is not possible for all species, several computational PPI prediction methods have been developed that harness existing data from other species.
Katherine James, Jose Muñoz-Muñoz
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