Results 11 to 20 of about 63,382 (353)
FEBS Letters, 2005 A long‐term goal of the field of interactome modeling is to understand how global and local properties of complex macromolecular networks impact on observable biological properties, and how changes in such properties can lead to human diseases. The information available at this stage of development of the field provides strong evidence for the ...
Vidal, Marc
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Advanced Biology, 2021 AbstractT cell activation is a fine‐tuned process that involves T cell receptor and costimulation signals. To prevent undue activation of T cells, inhibitory molecules including PD‐1 (programmed death 1) are induced and function as brakes for T cell signaling.
Qi Wang +3 more
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The interactome challenge [PDF]
Journal of Cell Biology, 2015 The properties of living cells are mediated by a huge number of ever-changing interactions of their component macromolecules forming living machines; collectively, these are termed the interactome. Pathogenic alterations in interactomes mechanistically underlie diseases.
Aitchison, John D., Rout, Michael P.
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The Hepatitis B Virus Interactome: A Comprehensive Overview
Frontiers in Microbiology, 2021 Despite the availability of a prophylactic vaccine, chronic hepatitis B (CHB) caused by the hepatitis B virus (HBV) is a major health problem affecting an estimated 292 million people globally.
Ellen Van Damme +5 more
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Comparative interactomics [PDF]
FEBS Letters, 2005 The behavior, morphology and response to stimuli in biological systems are dictated by the interactions between their components. These interactions, as we observe them now, are therefore shaped by genetic variations and selective pressure. Similar to what has been achieved by comparing genome structures and protein sequences, we hope to obtain ...
CESARENI, GIOVANNI +5 more
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Tick Importin-α Is Implicated in the Interactome and Regulome of the Cofactor Subolesin
Pathogens, 2021 Ticks and tick-borne diseases (TBDs) represent a burden for human and animal health worldwide. Currently, vaccines constitute the safest and most effective approach to control ticks and TBDs.
Sara Artigas-Jerónimo +13 more
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Frontiers in Oncology, 2022 Patients who develop testicular germ cell tumours (TGCT) are at higher risk to be subfertile than the general population. The conditions are believed to originate during foetal life, however, the mechanisms behind a common aetiology of TGCT and male ...
Joshua Burton +5 more
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Schizophrenia interactome: fully-labeled interactome network [PDF]
npj Schizophrenia, 2016 We recently published the schizophrenia interactome1 that showed hundreds of protein-protein interactions (PPIs) of schizophrenia-associated genes, including 504 novel PPIs. Figure 2 in that article gave an overview of how many known or novel PPIs each of the schizophrenia genes had, while the specific interactions were made available through a ...
Ganapathiraju, Madhavi +1 more
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Antioxidants, 2021 Age-related macular degeneration (AMD) is a complex degenerative disease of the retina with multiple risk-modifying factors, including aging, genetics, and lifestyle choices.
David A. Merle +7 more
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A reference map of the human binary protein interactome
Nature, 2020 Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype–phenotype relationships1,2.
Katja Luck +87 more
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