Results 11 to 20 of about 19,346 (166)
Letter to the Editor – Oral microbiota, health and cancer: the dual face of the same coin in the field of the host-microbe interactome [PDF]
World Cancer Research Journal, 2021 Dear Editor In recent years, within the extensive research regarding human microbiota and chronic diseases, new medical and laboratory technologies have played a crucial role in understanding more complex biological pathways between human cells and ...
V. Garau +4 more
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Advanced Biology, 2021 AbstractT cell activation is a fine‐tuned process that involves T cell receptor and costimulation signals. To prevent undue activation of T cells, inhibitory molecules including PD‐1 (programmed death 1) are induced and function as brakes for T cell signaling.
Qi Wang +3 more
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Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network: a systems level model of adaptation. [PDF]
PLoS Computational Biology, 2011 Network analysis became a powerful tool giving new insights to the understanding of cellular behavior. Heat shock, the archetype of stress responses, is a well-characterized and simple model of cellular dynamics. S.
Ágoston Mihalik, Peter Csermely
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Frontiers in Molecular Neuroscience, 2022 Despite the knowledge that mutation, multiplication, and anomalous function of α-synuclein cause progressive transformation of α-synuclein monomers into toxic amyloid fibrils in neurodegenerative diseases, the understanding of canonical signaling ...
Sharad Kumar Suthar +2 more
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The interactome challenge [PDF]
Journal of Cell Biology, 2015 The properties of living cells are mediated by a huge number of ever-changing interactions of their component macromolecules forming living machines; collectively, these are termed the interactome. Pathogenic alterations in interactomes mechanistically underlie diseases.
Aitchison, John D., Rout, Michael P.
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Deep interactome learning for de novo drug design [PDF]
, 2023 De novo drug design aims to generate molecules from scratch that possess specific chemical and pharmacological properties. We present a computational approach utilizing interactome-based deep learning for ligand- and structure-based generation of drug ...
Leandro, Cotos Muñoz +15 more
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Genomic data integration systematically biases interactome mapping. [PDF]
PLoS Computational Biology, 2018 Elucidating the complete network of protein-protein interactions, or interactome, is a fundamental goal of the post-genomic era, yet existing interactome maps are far from complete.
Michael A Skinnider +2 more
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The Hepatitis B Virus Interactome: A Comprehensive Overview
Frontiers in Microbiology, 2021 Despite the availability of a prophylactic vaccine, chronic hepatitis B (CHB) caused by the hepatitis B virus (HBV) is a major health problem affecting an estimated 292 million people globally.
Ellen Van Damme +5 more
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Tick Importin-α Is Implicated in the Interactome and Regulome of the Cofactor Subolesin
Pathogens, 2021 Ticks and tick-borne diseases (TBDs) represent a burden for human and animal health worldwide. Currently, vaccines constitute the safest and most effective approach to control ticks and TBDs.
Sara Artigas-Jerónimo +13 more
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Comparative interactomics [PDF]
FEBS Letters, 2005 The behavior, morphology and response to stimuli in biological systems are dictated by the interactions between their components. These interactions, as we observe them now, are therefore shaped by genetic variations and selective pressure. Similar to what has been achieved by comparing genome structures and protein sequences, we hope to obtain ...
CESARENI, GIOVANNI +5 more
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