Results 11 to 20 of about 38,917 (265)
Advanced Biology, 2021 AbstractT cell activation is a fine‐tuned process that involves T cell receptor and costimulation signals. To prevent undue activation of T cells, inhibitory molecules including PD‐1 (programmed death 1) are induced and function as brakes for T cell signaling.
Qi Wang +3 more
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The interactome challenge [PDF]
Journal of Cell Biology, 2015 The properties of living cells are mediated by a huge number of ever-changing interactions of their component macromolecules forming living machines; collectively, these are termed the interactome. Pathogenic alterations in interactomes mechanistically underlie diseases.
Aitchison, John D., Rout, Michael P.
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Comparative interactomics [PDF]
FEBS Letters, 2005 The behavior, morphology and response to stimuli in biological systems are dictated by the interactions between their components. These interactions, as we observe them now, are therefore shaped by genetic variations and selective pressure. Similar to what has been achieved by comparing genome structures and protein sequences, we hope to obtain ...
CESARENI, GIOVANNI +5 more
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Schizophrenia interactome: fully-labeled interactome network [PDF]
npj Schizophrenia, 2016 We recently published the schizophrenia interactome1 that showed hundreds of protein-protein interactions (PPIs) of schizophrenia-associated genes, including 504 novel PPIs. Figure 2 in that article gave an overview of how many known or novel PPIs each of the schizophrenia genes had, while the specific interactions were made available through a ...
Ganapathiraju, Madhavi +1 more
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Viruses and Interactomes in Translation [PDF]
Molecular & Cellular Proteomics, 2012 A decade of high-throughput screenings for intraviral and virus-host protein-protein interactions led to the accumulation of data and to the development of theories on laws governing interactome organization for many viruses. We present here a computational analysis of intraviral protein networks (EBV, FLUAV, HCV, HSV-1, KSHV, SARS-CoV, VACV, and VZV ...
Meyniel-Schicklin, Laurène +3 more
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EMBO Reports, 2023 When scientists marry each other their chances of both finding satisfactory academic jobs diminishes. What can be done to help them fulfil their potential?
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A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology
eLife, 2022 Neuroscience currently requires the use of antibodies to study synaptic proteins, where antibody binding is used as a correlate to define the presence, plasticity, and regulation of synapses. Gephyrin is an inhibitory synaptic scaffolding protein used to
Benjamin FN Campbell +4 more
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Interactome Analysis Identifies MSMEI_3879 as a Substrate of Mycolicibacterium smegmatis ClpC1
Microbiology Spectrum, 2023 The prevalence of drug-resistant Mycobacterium tuberculosis infections has prompted extensive efforts to exploit new drug targets in this globally important pathogen.
Emmanuel C. Ogbonna +4 more
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Life, 2023 Cystatin B is a small, multifunctional protein involved in the regulation of inflammation, innate immune response, and neuronal protection and found highly abundant in the brains of patients with Alzheimer’s disease (AD). Recently, our study demonstrated
Cristina Contini +12 more
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Molecules, 2020 (1) Background: voltage-gated sodium channels (Navs) are integral membrane proteins that allow the sodium ion flux into the excitable cells and initiate the action potential.
Fernando Villa-Diaz +4 more
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