Results 41 to 50 of about 53,983 (298)
Frontiers in Molecular Biosciences, 2022 At the heart of the cellular machinery through the regulation of cellular functions, protein–protein interactions (PPIs) have a significant role. PPIs can be analyzed with network approaches.
Vivian Robin +5 more
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Building the DREAM interactome [PDF]
Science China Life Sciences, 2011 DREAM/calsenilin/KChIP3 is a calcium binding protein of the neuronal calcium sensor superfamily. DREAM interacts with DRE (downstream regulatory element) sites in the DNA to regulate transcription and with many proteins to exert specialized functions in different subcellular compartments.
Rivas, Marcos +5 more
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BAG3 Proteomic Signature under Proteostasis Stress
Cells, 2020 The multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3) represents a key player in the quality control of the cellular proteostasis network.
Christof Hiebel +8 more
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VDAC3 Interactomic Analysis [PDF]
Biophysical Journal, 2014 VDACs (voltage-dependent anion channel), are a small family of proteins of the mitochondrial outer membrane, considered as gatekeeper of mitochondrial metabolites and thereby controlling cross-talk between mitochondria and the rest of the cell (1-2). VDAC is also a key player in mitochondria-mediated apoptosis (3).
MESSINA, Angela Anna +6 more
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Recent Advances in Chemical Biology Using Benzophenones and Diazirines as Radical Precursors
Molecules, 2020 The use of light-activated chemical probes to study biological interactions was first discovered in the 1960s, and has since found many applications in studying diseases and gaining deeper insight into various cellular mechanisms involving protein ...
Muhammad Murtaza Hassan +1 more
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Interactome-guided topographic maps of cancer chaperome shifts.
, 2018 A. Cancer-specific chaperome meta-interactome networks, collapsing network nodes and edges onto meta-nodes and meta-edges, highlight cancer-specific gene expression changes of chaperome functional families in context of connectivity within the high ...
Ali Hadizadeh Esfahani (4731474) +4 more
core +1 more source
Biology, 2020 Mitochondria are highly dynamic and regulated organelles implicated in a variety of important functions in the cell, including energy production, fatty acid metabolism, iron homeostasis, programmed cell death, and cell signaling. Changes in mitochondrial
Loredana Moro
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Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers
eLife, 2017 The amyloid β peptide (Aβ) is a key player in the etiology of Alzheimer disease (AD), yet a systematic investigation of its molecular interactions has not been reported. Here we identified by quantitative mass spectrometry proteins in human brain extract
Hansen Wang +12 more
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Collagen Structure-Function Mapping Informs Applications for Regenerative Medicine
Bioengineering, 2020 Type I collagen, the predominant protein of vertebrates, assembles into fibrils that orchestrate the form and function of bone, tendon, skin, and other tissues.
James D. San Antonio +3 more
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A Predicted Interactome for Arabidopsis [PDF]
Plant Physiology, 2007 Abstract The complex cellular functions of an organism frequently rely on physical interactions between proteins. A map of all protein-protein interactions, an interactome, is thus an invaluable tool. We present an interactome for Arabidopsis (Arabidopsis thaliana) predicted from interacting orthologs in yeast (Saccharomyces ...
Jane, Geisler-Lee +5 more
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