Results 51 to 60 of about 53,983 (298)

Interactome network of NAC TFs.

, 2020
The interactome network of NAC TF reflects a diverse complex of interacting proteins. The NAC TFs of A. thaliana were utilized in the interactome network analysis. The interactome map of A.
Elsayed Fathi Abd_Allah (4510309), Abeer Hashem (4510312), Dhananjay Yadav (713572), Abdul Latif Khan (7537550), Ahmed Al-Harrasi (556399), Tapan Kumar Mohanta (8698095), Baby Tabassum (8698098), Adil Khan (6195395)   +7 more
core   +1 more source

Tools for 3D Interactome Visualization

, 2018
In cells, intra- and intermolecular interactions of proteins confer function, and the dynamic modulation of this interactome is critical to meet the changing needs required to support life. Cross-linking and mass spectrometry (XL–MS) enable the detection
Andrew Keller (4334), James E. Bruce (177406), Zorian Thornton (6092039), Juan D. Chavez (219608), Jimmy K. Eng (2087374)   +4 more
core   +2 more sources

Loss of correlated proteasomal subunit expression selectively promotes the 20SHigh state which underlies luminal breast tumorigenicity

Communications Biology
Why cancer cells disproportionately accumulate polyubiquitinated proteotoxic proteins despite high proteasomal activity is an outstanding question. While mis-regulated ubiquitination is a contributing factor, here we show that a structurally-perturbed ...
Rangapriya Sundararajan, Shubhada R. Hegde, Ashish Kumar Panda, Joel Christie, Nikhil Gadewal, Prasanna Venkatraman   +5 more
doaj   +1 more source

interactome

, 2019
Bacteria play key roles in the function and diversity of aquatic systems, but aside from study of specific bloom systems, little is known about the diversity or biogeography of bacteria associated with harmful cyanobacterial blooms (cyanoHABs).
Boqiang Qin, Hambright, K. David, Delphine Latour, Paerl, Hans W, Hamilton, David P, Cai, Haiyuan, Padisak, Judit, Hambright, K David, Krumholz, Lee R., Steffen, Morgan M., Cook, Katherine, Qin, Boqiang, K. David Hambright, Katherine V. Cook, Assaf Sukenik, Morgan M. Steffen, Judit Padisák, Zhu, Guangwei, Meyer, Elisabeth I, Michele A. Burford, David P. Hamilton, Hans‐Peter Grossart, Jiang, Helong, Hamilton, David P., Latour, Delphine, Richard M. Zamor, Guangwei Zhu, Li, Chuang, Elisabeth I. Meyer, Haiyuan Cai, Paerl, Hans W., Burford, Michele A, Hans W. Paerl, Helong Jiang, Zamor, Richard M, Grossart, Hans-Peter, Meyer, Elisabeth I., Meyer, Elisabeth, Grossart, Hans-Peter (Prof. Dr.), Cook, Katherine V., Alan E. Wilson, Wilson, Alan E., Sukenik, Assaf, Lee R. Krumholz, Chuang Li, Cook, Katherine V, Burford, Michele A., Steffen, Morgan M, Wilson, Alan E, Zamor, Richard M., Krumholz, Lee R   +50 more
core   +1 more source

Interactome Networks and Human Disease [PDF]

, 2011
Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing ...
Michael E. Cusick, Albert-László Barabási, Vidal, Marc, Cusick, Michael E., Marc Vidal, Barabási, Albert-László   +5 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes

Frontiers in Molecular Neuroscience, 2020
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanisms neurons use to regulate its membrane trafficking, stability and activity are ill-defined.
Joshua L. Smalley, Georgina Kontou, Georgina Kontou, Catherine Choi, Qiu Ren, David Albrecht, David Albrecht, Krithika Abiraman, Krithika Abiraman, Miguel A. Rodriguez Santos, Christopher E. Bope, Tarek Z. Deeb, Tarek Z. Deeb, Paul A. Davies, Nicholas J. Brandon, Nicholas J. Brandon, Stephen J. Moss, Stephen J. Moss   +17 more
doaj   +1 more source

The IA-2 interactome [PDF]

Diabetologia, 2005
Islet antigen-2 (IA-2), a major autoantigen in type 1 diabetes, is an enzymatically inactive member of the transmembrane protein tyrosine phosphatase (PTP) family. IA-2 is located in dense-core secretory vesicles and is involved in the regulation of insulin secretion.
Notkins, A. L., Cai, T., Hu, Y. F., Zhang, H. L., Harashima, S.   +4 more
openaire   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Interactome Networks

The FASEB Journal, 2008
For over half a century it has been conjectured that macromolecules form complex networks of functionally interacting components, and that the molecular mechanisms underlying most biological processes correspond to particular steady states adopted by such cellular networks. However, until recently, systems‐level theoretical conjectures remained largely
openaire   +1 more source