Results 51 to 60 of about 63,382 (353)

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

bioRxiv, 2020
The ongoing coronavirus disease (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a global public health concern due to relatively easy person-to-person transmission and the current lack of effective antiviral ...
Jingjiao Li, M. Guo, Xiaoxu Tian, Chengrong Liu, Xin Wang, Xing-Liang Yang, Ping Wu, Zixuan Xiao, Yafei Qu, Yue Yin, Joyce Fu, Zhaoqin Zhu, Zhenshan Liu, Chao Peng, T. Zhu, Q. Liang   +15 more
semanticscholar   +1 more source

JAK‐STAT core cancer pathway: An integrative cancer interactome analysis

Journal of Cellular and Molecular Medicine, 2022
Through a comprehensive review and in silico analysis of reported data on STAT‐linked diseases, we analysed the communication pathways and interactome of the seven STATs in major cancer categories and proposed rational targeting approaches for ...
Fettah Erdogan, T. Radu, A. Orlova, Abdul K. Qadree, E. D. de Araujo, Johan Israelian, P. Valent, S. Mustjoki, M. Herling, R. Moriggl, P. Gunning   +10 more
semanticscholar   +1 more source

Production of T. gondii transgenic strains to characterize the tubulin cofactor B interactome [PDF]

, 2021
Projeto "Characterization of the T. gondii TBCB interactome" (UID/CVT/00276/2019)Mestrado em Tecnologias Moleculares em SaúdeToxoplasma gondii é um parasita intracelular obrigatório que infeta a maioria dos animais, apresentando uma distribuição mundial.
Veva, Ana Madalena Martins
core  

In-Depth Bioinformatic Study of the CLDN16 Gene and Protein: Prediction of Subcellular Localization to Mitochondria

Medicina, 2019
Background and Objectives: The defects in the CLDN16 gene are a cause of primary hypomagnesemia (FHHNC), which is characterized by massive renal magnesium wasting, resulting in nephrocalcinosis and renal failure.
Erasmia Rouka, Vassilios Liakopoulos, Konstantinos I. Gourgoulianis, Chrissi Hatzoglou, Sotirios G. Zarogiannis   +4 more
doaj   +1 more source

The SARS-CoV-2 RNA–protein interactome in infected human cells

Nature Microbiology, 2020
Characterizing the interactions that SARS-CoV-2 viral RNAs make with host cell proteins during infection can improve our understanding of viral RNA functions and the host innate immune response.
Nora Schmidt, C. Lareau, Hasmik Keshishian, Sabina Ganskih, Cornelius Schneider, Thomas Hennig, Randy A Melanson, Simone Werner, Yuanjie Wei, Matthias M. Zimmer, Jens Ade, Luisa Kirschner, Sebastian Zielinski, L. Dölken, E. Lander, Neva Caliskan, U. Fischer, J. Vogel, S. Carr, J. Bodem, Mathias Munschauer   +20 more
semanticscholar   +1 more source

Interactome INSIDER: a structural interactome browser for genomic studies [PDF]

Nature Methods, 2018
We present Interactome INSIDER, a tool to link genomic variant information with structural protein-protein interactomes. Underlying this tool is the application of machine learning to predict protein interaction interfaces for 185,957 protein interactions with previously unresolved interfaces in human and seven model organisms, including the entire ...
Michael J Meyer, Juan Felipe Beltrán, Siqi Liang, Robert Fragoza, Aaron Rumack, Jin Liang, Xiaomu Wei, Haiyuan Yu   +7 more
openaire   +2 more sources

Overview of methods for characterization and visualization of a protein–protein interaction network in a multi-omics integration context

Frontiers in Molecular Biosciences, 2022
At the heart of the cellular machinery through the regulation of cellular functions, protein–protein interactions (PPIs) have a significant role. PPIs can be analyzed with network approaches.
Vivian Robin, Antoine Bodein, Marie-Pier Scott-Boyer, Mickaël Leclercq, Olivier Périn, Arnaud Droit   +5 more
doaj   +1 more source

Architecture of the human interactome defines protein communities and disease networks

Nature, 2017
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein–protein interactions that assemble functionally related proteins
Edward L. Huttlin, Raphael J. Bruckner, J. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, G. Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, G. Zárraga, Laura Pontano-Vaites, Sharan Swarup, A. White, Devin K. Schweppe, R. Rad, B. Erickson, R. Obar, R. Obar, K. G. Guruharsha, Kejie Li, S. Artavanis-Tsakonas, S. Artavanis-Tsakonas, S. Gygi, J. Harper   +26 more
semanticscholar   +1 more source

Phosphorylated tau interactome in the human Alzheimer’s disease brain

Brain : a journal of neurology, 2020
Accumulation of phosphorylated tau (pTau) is a key pathological feature of Alzheimer’s disease (AD). pTau accumulation causes synaptic impairment, neuronal dysfunction and formation of neurofibrillary tangles (NFTs).
Eleanor Drummond, Geoffrey Pires, Claire MacMurray, M. Askenazi, Shruti D Nayak, M. Bourdon, J. Safar, B. Ueberheide, T. Wisniewski   +8 more
semanticscholar   +1 more source

BAG3 Proteomic Signature under Proteostasis Stress

Cells, 2020
The multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3) represents a key player in the quality control of the cellular proteostasis network.
Christof Hiebel, Elisabeth Stürner, Meike Hoffmeister, Georg Tascher, Mario Schwarz, Heike Nagel, Christian Behrends, Christian Münch, Christian Behl   +8 more
doaj   +1 more source