Results 51 to 60 of about 19,346 (166)
Modelling the Yeast Interactome [PDF]
Scientific Reports, 2014 The topology behind biological interaction networks has been studied for over a decade. Yet, there is no definite agreement on the theoretical models which best describe protein-protein interaction (PPI) networks. Such models are critical to quantifying the significance of any empirical observation regarding those networks.
V. Janjic, R. Sharan, and N. Przulj
openaire +2 more sources
Biology, 2020 Mitochondria are highly dynamic and regulated organelles implicated in a variety of important functions in the cell, including energy production, fatty acid metabolism, iron homeostasis, programmed cell death, and cell signaling. Changes in mitochondrial
Loredana Moro
doaj +1 more source
The glycosaminoglycan interactome 2.0
American Journal of Physiology-Cell Physiology, 2022 Glycosaminoglycans (GAGs) are complex linear polysaccharides, which are covalently attached to core proteins (except for hyaluronan) to form proteoglycans. They play key roles in the organization of the extracellular matrix, and at the cell surface where they contribute to the regulation of cell signaling and of cell adhesion. To explore the mechanisms
Vallet, Sylvain +2 more
openaire +3 more sources
Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers
eLife, 2017 The amyloid β peptide (Aβ) is a key player in the etiology of Alzheimer disease (AD), yet a systematic investigation of its molecular interactions has not been reported. Here we identified by quantitative mass spectrometry proteins in human brain extract
Hansen Wang +12 more
doaj +1 more source
Collagen Structure-Function Mapping Informs Applications for Regenerative Medicine
Bioengineering, 2020 Type I collagen, the predominant protein of vertebrates, assembles into fibrils that orchestrate the form and function of bone, tendon, skin, and other tissues.
James D. San Antonio +3 more
doaj +1 more source
Structural Bioinformatics of the Interactome [PDF]
Annual Review of Biophysics, 2014 The past decade has seen a dramatic expansion in the number and range of techniques available to obtain genome-wide information and to analyze this information so as to infer both the functions of individual molecules and how they interact to modulate the behavior of biological systems.
Donald, Petrey, Barry, Honig
openaire +2 more sources
Interactome network of NAC TFs.
, 2020 The interactome network of NAC TF reflects a diverse complex of interacting proteins. The NAC TFs of A. thaliana were utilized in the interactome network analysis. The interactome map of A.
Elsayed Fathi Abd_Allah (4510309) +7 more
core +1 more source
The FASEB Journal, 2008 For over half a century it has been conjectured that macromolecules form complex networks of functionally interacting components, and that the molecular mechanisms underlying most biological processes correspond to particular steady states adopted by such cellular networks. However, until recently, systems‐level theoretical conjectures remained largely
openaire +1 more source
, 2019 Bacteria play key roles in the function and diversity of aquatic systems, but aside from study of specific bloom systems, little is known about the diversity or biogeography of bacteria associated with harmful cyanobacterial blooms (cyanoHABs).
Boqiang Qin +50 more
core +1 more source
Communications BiologyWhy cancer cells disproportionately accumulate polyubiquitinated proteotoxic proteins despite high proteasomal activity is an outstanding question. While mis-regulated ubiquitination is a contributing factor, here we show that a structurally-perturbed ...
Rangapriya Sundararajan +5 more
doaj +1 more source