Results 71 to 80 of about 63,382 (353)

Prospective de novo drug design with deep interactome learning

Nature Communications
De novo drug design aims to generate molecules from scratch that possess specific chemical and pharmacological properties. We present a computational approach utilizing interactome-based deep learning for ligand- and structure-based generation of drug ...
Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F. Nippa, Michael Iff, Jann Ledergerber, Carl C G Schiebroek, Valentina Romeo, J. A. Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, U. Grether, Gisbert Schneider   +16 more
semanticscholar   +1 more source

Applying systems-level spectral imaging and analysis to reveal the organelle interactome

Nature, 2017
The organization of the eukaryotic cell into discrete membrane-bound organelles allows for the separation of incompatible biochemical processes, but the activities of these organelles must be coordinated.
A. Valm, Sarah Cohen, W. Legant, Justin Melunis, Uri Hershberg, Eric Wait, Andrew R. Cohen, M. Davidson, E. Betzig, J. Lippincott-Schwartz   +9 more
semanticscholar   +1 more source

Structural Bioinformatics of the Interactome [PDF]

Annual Review of Biophysics, 2014
The past decade has seen a dramatic expansion in the number and range of techniques available to obtain genome-wide information and to analyze this information so as to infer both the functions of individual molecules and how they interact to modulate the behavior of biological systems.
Donald, Petrey, Barry, Honig
openaire   +2 more sources

Interactome network of NAC TFs.

, 2020
The interactome network of NAC TF reflects a diverse complex of interacting proteins. The NAC TFs of A. thaliana were utilized in the interactome network analysis. The interactome map of A.
Elsayed Fathi Abd_Allah (4510309), Abeer Hashem (4510312), Dhananjay Yadav (713572), Abdul Latif Khan (7537550), Ahmed Al-Harrasi (556399), Tapan Kumar Mohanta (8698095), Baby Tabassum (8698098), Adil Khan (6195395)   +7 more
core   +1 more source

Building the DREAM interactome [PDF]

Science China Life Sciences, 2011
DREAM/calsenilin/KChIP3 is a calcium binding protein of the neuronal calcium sensor superfamily. DREAM interacts with DRE (downstream regulatory element) sites in the DNA to regulate transcription and with many proteins to exert specialized functions in different subcellular compartments.
Rivas, Marcos, Villar, Diego, González, Paz, Dopazo, Xosé M., Mellstrom, Britt, Naranjo, José R.   +5 more
openaire   +2 more sources

interactome

, 2019
Bacteria play key roles in the function and diversity of aquatic systems, but aside from study of specific bloom systems, little is known about the diversity or biogeography of bacteria associated with harmful cyanobacterial blooms (cyanoHABs).
Boqiang Qin, Hambright, K. David, Delphine Latour, Paerl, Hans W, Hamilton, David P, Cai, Haiyuan, Padisak, Judit, Hambright, K David, Krumholz, Lee R., Steffen, Morgan M., Cook, Katherine, Qin, Boqiang, K. David Hambright, Katherine V. Cook, Assaf Sukenik, Morgan M. Steffen, Judit Padisák, Zhu, Guangwei, Meyer, Elisabeth I, Michele A. Burford, David P. Hamilton, Hans‐Peter Grossart, Jiang, Helong, Hamilton, David P., Latour, Delphine, Richard M. Zamor, Guangwei Zhu, Li, Chuang, Elisabeth I. Meyer, Haiyuan Cai, Paerl, Hans W., Burford, Michele A, Hans W. Paerl, Helong Jiang, Zamor, Richard M, Grossart, Hans-Peter, Meyer, Elisabeth I., Meyer, Elisabeth, Grossart, Hans-Peter (Prof. Dr.), Cook, Katherine V., Alan E. Wilson, Wilson, Alan E., Sukenik, Assaf, Lee R. Krumholz, Chuang Li, Cook, Katherine V, Burford, Michele A., Steffen, Morgan M, Wilson, Alan E, Zamor, Richard M., Krumholz, Lee R   +50 more
core   +1 more source

Motile cilia interactome data

, 2023
This data includes XL/MS and structural models for the Tetrahymena motile cilia ...
Edward M. Marcotte, Chanjae Lee, John B. Wallingford, Caitlyn L. McCafferty, Khanh Huy Bui, Ophelia Papoulas, David W. Taylor   +6 more
core   +1 more source

Tools for 3D Interactome Visualization

, 2018
In cells, intra- and intermolecular interactions of proteins confer function, and the dynamic modulation of this interactome is critical to meet the changing needs required to support life. Cross-linking and mass spectrometry (XL–MS) enable the detection
Andrew Keller (4334), James E. Bruce (177406), Zorian Thornton (6092039), Juan D. Chavez (219608), Jimmy K. Eng (2087374)   +4 more
core   +2 more sources

Loss of correlated proteasomal subunit expression selectively promotes the 20SHigh state which underlies luminal breast tumorigenicity

Communications Biology
Why cancer cells disproportionately accumulate polyubiquitinated proteotoxic proteins despite high proteasomal activity is an outstanding question. While mis-regulated ubiquitination is a contributing factor, here we show that a structurally-perturbed ...
Rangapriya Sundararajan, Shubhada R. Hegde, Ashish Kumar Panda, Joel Christie, Nikhil Gadewal, Prasanna Venkatraman   +5 more
doaj   +1 more source

Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes

Frontiers in Molecular Neuroscience, 2020
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanisms neurons use to regulate its membrane trafficking, stability and activity are ill-defined.
Joshua L. Smalley, Georgina Kontou, Georgina Kontou, Catherine Choi, Qiu Ren, David Albrecht, David Albrecht, Krithika Abiraman, Krithika Abiraman, Miguel A. Rodriguez Santos, Christopher E. Bope, Tarek Z. Deeb, Tarek Z. Deeb, Paul A. Davies, Nicholas J. Brandon, Nicholas J. Brandon, Stephen J. Moss, Stephen J. Moss   +17 more
doaj   +1 more source