Results 21 to 30 of about 543,435 (291)
Reconstructing genome-wide protein-protein interaction networks using multiple strategies with homologous mapping. [PDF]
PLoS ONE, 2015 BACKGROUND:One of the crucial steps toward understanding the biological functions of a cellular system is to investigate protein-protein interaction (PPI) networks.
Yu-Shu Lo +4 more
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Protein-protein interaction map for yeast TFIID [PDF]
Nucleic Acids Research, 2003 A major rate-limiting step in transcription initiation by RNA polymerase II is recognition and binding of the TATA element by the transcription factor TFIID. TFIID is composed of TATA binding protein (TBP) and approximately a dozen TBP-associated factors (TAFs).
Gayatri, Yatherajam +3 more
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Comparison of human protein–protein interaction maps [PDF]
Bioinformatics, 2007 AbstractMotivation: Large-scale mappings of protein–protein interactions have started to give us new views of the complex molecular mechanisms inside a cell. After initial projects to systematically map protein interactions in model organisms such as yeast, worm and fly, researchers have begun to focus on the mapping of the human interactome. To tackle
Matthias E, Futschik +2 more
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Computational and Structural Biotechnology Journal, 2022 As one of the most studied Apicomplexan parasite Cryptosporidium, Cryptosporidium parvum (C. parvum) causes worldwide serious diarrhea disease cryptosporidiosis, which can be deadly to immunodeficiency individuals, newly born children, and animals ...
Panyu Ren +4 more
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Pan-cancer mapping of differential protein-protein interactions [PDF]
Scientific Reports, 2020 AbstractDeciphering the variations in the protein interactome is required to reach a systems-level understanding of tumorigenesis. To accomplish this task, we have considered the clinical and transcriptome data on >6000 samples from The Cancer Genome Atlas for 12 different cancers.
Gulfidan, Gizem +4 more
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Mapping oncogenic protein interactions for precision medicine [PDF]
International Journal of Cancer, 2022 AbstractNormal protein‐protein interactions (normPPIs) occur with high fidelity to regulate almost every physiological process. In cancer, this highly organised and precisely regulated network is disrupted, hijacked or reprogrammed resulting in oncogenic protein‐protein interactions (oncoPPIs). OncoPPIs, which can result from genomic alterations, are a
Mehdi Sharifi Tabar +4 more
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Frontiers in Genetics, 2021 Inflammatory bowel disease (IBD) is the common name for chronic disorders associated with the inflammation of the gastrointestinal tract. IBD is triggered by environmental factors in genetically susceptible individuals and has a significant number of ...
Sefika Feyza Maden, Saliha Ece Acuner
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PathExpand: Extending biological pathways using molecular interaction networks [PDF]
, 2011 We present a methodology for extending pre-defined protein sets representing cellular pathways and processes by mapping them onto a protein-protein interaction network, and extending them to include densely interconnected interaction partners.
Alfonso Valencia +3 more
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Identification of Breast Cancer Biomarkers by Constructing Protein-Protein Interaction and miRNAs-mRNAs Networks [PDF]
Middle East Journal of CancerBackground: In cancer-related diseases, early detection and control of disease progression are very important for successful treatment. Breast cancer is a significant problem due to its high mortality rate in the female population worldwide. By the early
Azizeh Asadzadeh +3 more
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FEBS Open Bio, 2022 Over the past few decades, dozens of in vitro methods have been developed to map, investigate and validate protein–protein interactions. However, most of these approaches are time‐consuming and labour‐intensive or require specialised equipment or ...
Zsuzsánna Réthi‐Nagy +2 more
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