Results 81 to 90 of about 453,402 (256)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Serum Proteomic Study of Women With Obsessive-Compulsive Disorder, Washing Subtype

Basic and Clinical Neuroscience, 2018
Introduction: Many genetic studies are conducted on Obsessive-Compulsive Disorder (OCD). however, a high-throughput examination of proteome profile of this severe disease has not been performed yet.
Mona Zamanian-Azodi, Mostafa Rezaei-Tavirani, Mohammad Mahboubi, Mohsen Hamidpour, Majid Rezaei Tavirani, Mostafa Hamdieh, Mohammad Rostami-Nejad, Naser Nejadi, Mohammad Kamran Derakhshan   +8 more
doaj  

Discover Protein Complexes in Protein-Protein Interaction Networks Using Parametric Local Modularity

BMC Bioinformatics, 2010
Background Recent advances in proteomic technologies have enabled us to create detailed protein-protein interaction maps in multiple species and in both normal and diseased cells.
Tan Kai, Kim Jongkwang
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Multi-Institutional Pragmatic Randomized Controlled Trial to Evaluate the Effectiveness of Manual Maintenance Therapy for Chronic Bothersome Neck Pain [Response to Letter]

Journal of Pain Research
Jung Min Yun,1 Ju Yeon Kim,2 Sook-Hyun Lee,2 Yoon Jae Lee,2 In Heo,3 Woo-Chul Shin,4 Jae-Heung Cho,5 Byung-Kwan Seo,6 In-Hyuk Ha2 1Jaseng Hospital of Korean Medicine, Seoul, Republic of Korea; 2Jaseng Spine and Joint Research Institute, Jaseng Medical ...
Yun JM, Kim JY, Lee SH, Lee YJ, Heo I, Shin WC, Cho JH, Seo BK, Ha IH   +8 more
doaj  

Imaging Fos-Jun transcription factor mobility and interaction in live cells by single plane illumination-fluorescence cross correlation spectroscopy.

PLoS ONE, 2015
We collected mobility and interaction maps of c-Fos-eGFP and c-Jun-mRFP1 transcription factors within living cell nuclei. c-Fos dimerizes with c-Jun to form the transcription activator protein-1 (AP-1) which binds to the specific recognition site.
Agata Pernuš, Jörg Langowski
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Mapping interactions of Chikungunya virus nonstructural proteins

Virus Research, 2012
The four nonstructural proteins (nsPs1-4) of Chikungunya virus (CHIKV) play important roles involving enzymatic activities and specific interactions with both viral and host components, during different stages of viral pathogenesis. Elucidation of the presence and/or absence of interactions among nsPs in a systematic manner is thus of scientific ...
R, Sreejith, Jyoti, Rana, Namrata, Dudha, Kapila, Kumar, Reema, Gabrani, Sanjeev K, Sharma, Amita, Gupta, Sudhanshu, Vrati, Vijay K, Chaudhary, Sanjay, Gupta   +9 more
openaire   +2 more sources

PPI-ID: Streamlining protein-protein interaction prediction through domain and SLiM mapping.

PLoS Computational Biology
AlphaFold-Multimer models protein complexes and facilitates protein-protein interaction (PPI) prediction. Mapping of protein interaction domains and motifs onto the 3D structure can lend credence to the model and provide insight into the function of a ...
Haley V Goodwin, Nigel S Atkinson
doaj   +1 more source