Results 51 to 60 of about 453,402 (256)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Introducing Genes With Significant Role in Migraine: An Interactomic Approach

Basic and Clinical Neuroscience, 2019
Introduction: Migraine is a severe kind of headache with the chance hereditary of 50%. Molecular studies can promote understanding of migraine pathophysiology.
Mona Zamanian-Azodi, Mostafa Rezaei-Tavirani, Reza Mahmoud Robati   +2 more
doaj  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

In silico analysis of Ziziphus mauritiana Lam. bioactive compounds targeting GABA receptor and ADMET profiles for potential postpartum depression treatment [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Postpartum depression (PPD) affects 10–20% of women and has been associated with disruptions in neurotransmitter systems, neuroinflammation, and oxidative stress.
Ruri Y. Astari, Sri Winarsih, Dian Handayani, Heni D. Windarwati, Holipah, Bambang Rahardjo   +5 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

PEPpip: A Vision-Inspired Explainable Deep Learning Framework for Sequence-Based Protein–Protein Interaction Prediction and Interaction Map Estimation

IEEE Access
Predicting protein–protein interaction (PPI) patterns from primary sequences constitutes a complex pattern recognition task that demands advanced and explainable deep learning frameworks, as PPIs underpin critical cellular and pathological ...
Shubhrangshu Ghosh, Pralay Mitra
doaj   +1 more source

Toward an understanding of the protein interaction network of the human liver

Molecular Systems Biology, 2011
Proteome‐scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery.
Jian Wang, Keke Huo, Lixin Ma, Liujun Tang, Dong Li, Xiaobi Huang, Yanzhi Yuan, Chunhua Li, Wei Wang, Wei Guan, Hui Chen, Chaozhi Jin, Junchen Wei, Wanqiao Zhang, Yongsheng Yang, Qiongming Liu, Ying Zhou, Cuili Zhang, Zhihao Wu, Wangxiang Xu, Ying Zhang, Tao Liu, Donghui Yu, Yaping Zhang, Liang Chen, Dewu Zhu, Xing Zhong, Lixin Kang, Xiang Gan, Xiaolan Yu, Qi Ma, Jing Yan, Li Zhou, Zhongyang Liu, Yunping Zhu, Tao Zhou, Fuchu He, Xiaoming Yang   +37 more
doaj   +1 more source

Integrated proteomics identifies a dysfunctional acrosomal module associated with impaired acrosome reaction in asthenozoospermia [PDF]

Journal of Men's Health
Background: Asthenozoospermia, a primary cause of male infertility, is characterized not only by reduced sperm motility, but also by functional impairments, particularly defects in the acrosome reaction.
Andu Zhu, Jie Zhu, Dongdong Jin
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source