Results 41 to 50 of about 1,962,138 (310)

Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome [PDF]

, 2007
The severe acute respiratory syndrome coronavirus (SARS-CoV) genome is predicted to encode 14 functional open reading frames, leading to the expression of up to 30 structural and non-structural protein products.
Brunn, Albrecht von, Teepe, Carola, Caroline C Friedel, Ralph Baric, Haas, Jürgen, von Brunn, Albrecht, Simpson Jeremy C., Jeremy C. Simpson, Simpson, Jeremy C., Ralf Zimmer, Roberts, Rhonda, Carola Teepe, Rainer Pepperkok, Baric Ralph, Haas Jürgen, Simpson, Jeremy, Zimmer, Ralf, Zimmer Ralf, Caroline C. Friedel, Friedel, Caroline C., Haas, Juergen, Teepe Carola, Albrecht von Brunn, Rhonda Roberts, Jürgen Haas, Friedel Caroline C., Pepperkok Rainer, Pepperkok, Rainer, Roberts Rhonda, Baric, Ralph, Jeremy C Simpson, von Brunn Albrecht   +31 more
core   +1 more source

Aromatic clusters in protein–protein and protein–drug complexes

Journal of Cheminformatics, 2020
Aromatic rings are important residues for biological interactions and appear to a large extent as part of protein–drug and protein–protein interactions. They are relevant for both protein stability and molecular recognition processes due to their natural
Esteban Lanzarotti, Lucas A. Defelipe, Marcelo A. Marti, Adrián G. Turjanski   +3 more
doaj   +1 more source

Analysis of leukocyte membrane protein interactions using protein microarrays

, 2005
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work
Foster-Cuevas, M, Letarte, Michelle, Deborah Hatherley, Foster-Cuevas, Mildred, Hatherley, D, Barclay, AN, Michelle Letarte, Saunders, Nigel, A Neil Barclay, Saunders, NJ, Hatherley, Deborah, Letarte, M, Barclay, Neil, Mildred Foster-Cuevas, Nigel J Saunders, Saunders, Nigel J, Voulgaraki, D, Despina Voulgaraki, Voulgaraki, Despina   +18 more
core   +1 more source

Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site

Nature Communications, 2016
The host cell factor cyclophilin A (CypA) interacts with the HIV-1 capsid and regulates infectivity. Here the authors combine cryo-EM, solid-state NMR and all-atom MD simulations, identifying an interaction interface between CypA and the HIV capsid that ...
Chuang Liu, Juan R. Perilla, Jiying Ning, Manman Lu, Guangjin Hou, Ruben Ramalho, Benjamin A. Himes, Gongpu Zhao, Gregory J. Bedwell, In-Ja Byeon, Jinwoo Ahn, Angela M. Gronenborn, Peter E. Prevelige, Itay Rousso, Christopher Aiken, Tatyana Polenova, Klaus Schulten, Peijun Zhang   +17 more
doaj   +1 more source

A Unique Human Immunoglobulin Heavy Chain Variable Domain-Only CD33 CAR for the Treatment of Acute Myeloid Leukemia

Frontiers in Oncology, 2018
Acute myeloid leukemia (AML) remains a challenging pediatric and adult disease. Given the elevated expression of the CD33 antigen on leukemic blasts, therapeutic approaches to AML now feature the approved antibody drug conjugate (Mylotarg, GO) and ...
Dina Schneider, Ying Xiong, Peirong Hu, Darong Wu, Weizao Chen, Tianlei Ying, Tianlei Ying, Zhongyu Zhu, Zhongyu Zhu, Dimiter S. Dimitrov, Dimiter S. Dimitrov, Boro Dropulic, Rimas J. Orentas, Rimas J. Orentas   +13 more
doaj   +1 more source

Molecular basis for protein–protein interactions

Beilstein Journal of Organic Chemistry, 2021
This minireview provides an overview on the current knowledge of protein–protein interactions, common characterisation methods to characterise them, and their role in protein complex formation with some examples.
Brandon Charles Seychell, Tobias Beck
doaj   +1 more source

ProDGe: investigating protein-protein interactions at the domain level

, 2011
An important goal of systems biology is the identification and investigation of known and predicted protein-protein interactions to obtain more information about new cellular pathways and processes.
Andreas Dräger, Clemens Wrzodek, Adrian Schröder, Adrian Schröder, Florian Mittag, Andreas Zell, Finja Büchel, Andreas Dräger, Finja Büchel   +8 more
core   +1 more source

A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins [PDF]

, 2011
Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Leonardi, Emanuela, Tosatto, Silvio C. E., Giorgia Busolin, Simonetta Andreazza, Busolin, Giorgia, Tosatto, Silvio C E, Emanuela Leonardi, Carlo Nobile, Silvio C E Tosatto, TOSATTO, SILVIO, Busolin Giorgia, Silvio C. E. Tosatto, Tosatto Silvio C. E., Vanin, Stefano, Vanin Stefano, NOBILE C, Langowski, Jörg, Stefano Vanin, Andreazza Simonetta, Andreazza, Simonetta, Nobile, Carlo, ANDREAZZA A, Leonardi Emanuela, Nobile Carlo   +23 more
core   +1 more source

Antagonists of protein–protein interactions [PDF]

Chemistry & Biology, 2000
Protein-protein interactions are often attractive, but not straightforward, targets for disease therapy. Two strategies for identifying inhibitors of these interactions, peptide phage display and high-throughput screening, have recently shown new promise.
openaire   +2 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source