Results 41 to 50 of about 2,913,537 (285)
Homologous Recombination under the Single-Molecule Fluorescence Microscope [PDF]
, 2019 Homologous recombination (HR) is a complex biological process and is central to meiosis and for repair of DNA double-strand breaks. Although the HR process has been the subject of intensive study for more than three decades, the complex protein–protein ...
Dhakal, Soma, Gibbs, Dalton R.
core +2 more sources
Scientific Reports, 2017 Bispecific killer cells engagers (BiKEs) which can bind to natural killer (NK) cells through the activating receptor CD16A and guide them to cells expressing the HIV-1 envelope glycoprotein (Env) are a promising new weapon for elimination of infected ...
Wei Li +10 more
doaj +1 more source
Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid
Molecules, 2017 Circulating heptadecanoic acid (C17:0) is reported to be a pathology risk/prognosis biomarker and a dietary biomarker. This pathology relationship has been shown to be reliably predictive even when independent of dietary contributions, suggesting that ...
Benjamin Jenkins +3 more
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Disruption of nNOS-NOS1AP protein-protein interactions suppresses neuropathic pain in mice [PDF]
, 2018 Elevated N-methyl-D-aspartate receptor (NMDAR) activity is linked to central sensitization and chronic pain. However, NMDAR antagonists display limited therapeutic potential because of their adverse side effects. Novel approaches targeting the NR2B-PSD95-
Chawla, Aarti +6 more
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Aromatic clusters in protein–protein and protein–drug complexes
Journal of Cheminformatics, 2020 Aromatic rings are important residues for biological interactions and appear to a large extent as part of protein–drug and protein–protein interactions. They are relevant for both protein stability and molecular recognition processes due to their natural
Esteban Lanzarotti +3 more
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Structural Prediction of Protein–Protein Interactions by Docking: Application to Biomedical Problems [PDF]
, 2018 A huge amount of genetic information is available thanks to the recent advances in sequencing technologies and the larger computational capabilities, but the interpretation of such genetic data at phenotypic level remains elusive.
Barradas-Bautista, Didier +3 more
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Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site
Nature Communications, 2016 The host cell factor cyclophilin A (CypA) interacts with the HIV-1 capsid and regulates infectivity. Here the authors combine cryo-EM, solid-state NMR and all-atom MD simulations, identifying an interaction interface between CypA and the HIV capsid that ...
Chuang Liu +17 more
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Frontiers in Oncology, 2018 Acute myeloid leukemia (AML) remains a challenging pediatric and adult disease. Given the elevated expression of the CD33 antigen on leukemic blasts, therapeutic approaches to AML now feature the approved antibody drug conjugate (Mylotarg, GO) and ...
Dina Schneider +13 more
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Molecular basis for protein–protein interactions
Beilstein Journal of Organic Chemistry, 2021 This minireview provides an overview on the current knowledge of protein–protein interactions, common characterisation methods to characterise them, and their role in protein complex formation with some examples.
Brandon Charles Seychell, Tobias Beck
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Spectral Analysis of Protein-Protein Interactions in Drosophila melanogaster
, 2004 Within a case study on the protein-protein interaction network (PIN) of Drosophila melanogaster we investigate the relation between the network's spectral properties and its structural features such as the prevalence of specific subgraphs or duplicate ...
B. Bollobás +11 more
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