Results 41 to 50 of about 7,753,904 (295)
Scientific Reports, 2017 Bispecific killer cells engagers (BiKEs) which can bind to natural killer (NK) cells through the activating receptor CD16A and guide them to cells expressing the HIV-1 envelope glycoprotein (Env) are a promising new weapon for elimination of infected ...
Wei Li +10 more
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Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid
Molecules, 2017 Circulating heptadecanoic acid (C17:0) is reported to be a pathology risk/prognosis biomarker and a dietary biomarker. This pathology relationship has been shown to be reliably predictive even when independent of dietary contributions, suggesting that ...
Benjamin Jenkins +3 more
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Aromatic clusters in protein–protein and protein–drug complexes
Journal of Cheminformatics, 2020 Aromatic rings are important residues for biological interactions and appear to a large extent as part of protein–drug and protein–protein interactions. They are relevant for both protein stability and molecular recognition processes due to their natural
Esteban Lanzarotti +3 more
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Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site
Nature Communications, 2016 The host cell factor cyclophilin A (CypA) interacts with the HIV-1 capsid and regulates infectivity. Here the authors combine cryo-EM, solid-state NMR and all-atom MD simulations, identifying an interaction interface between CypA and the HIV capsid that ...
Chuang Liu +17 more
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Frontiers in Oncology, 2018 Acute myeloid leukemia (AML) remains a challenging pediatric and adult disease. Given the elevated expression of the CD33 antigen on leukemic blasts, therapeutic approaches to AML now feature the approved antibody drug conjugate (Mylotarg, GO) and ...
Dina Schneider +13 more
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Molecular basis for protein–protein interactions
Beilstein Journal of Organic Chemistry, 2021 This minireview provides an overview on the current knowledge of protein–protein interactions, common characterisation methods to characterise them, and their role in protein complex formation with some examples.
Brandon Charles Seychell, Tobias Beck
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Protein-Protein Interactions in Plants [PDF]
Plant and Cell Physiology, 2012 The study of protein-protein interactions (PPIs) is essential to uncover unknown functions of proteins at the molecular level and to gain insight into complex cellular networks. Affinity purification and mass spectrometry (AP-MS), yeast two-hybrid, imaging approaches and numerous diverse databases have been developed as strategies to analyze PPIs.
openaire +2 more sources
Length, protein–protein interactions, and complexity [PDF]
Physica A: Statistical Mechanics and its Applications, 2005 13 pages, 5 figures, 2 tables, to appear in Physica ...
Tan, T. +3 more
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source