Results 21 to 30 of about 1,962,138 (310)

Antibody Aggregation: Insights from Sequence and Structure

Antibodies, 2016
Monoclonal antibodies (mAbs) are the fastest-growing biological therapeutics with important applications ranging from cancers, autoimmunity diseases and metabolic disorders to emerging infectious diseases.
Wei Li, Ponraj Prabakaran, Weizao Chen, Zhongyu Zhu, Yang Feng, Dimiter S. Dimitrov   +5 more
doaj   +1 more source

Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling

Nature Communications, 2022
SHP2 is an important human tyrosine phosphatase with key roles in cancer, immune responses and insulin signaling. Here, the authors explore its substrate recognition mechanism in molecular detail and uncover a complex regulatory mechanism for this enzyme 
András Zeke, Tamás Takács, Péter Sok, Krisztina Németh, Klára Kirsch, Péter Egri, Ádám Levente Póti, Isabel Bento, Gábor E. Tusnády, Attila Reményi   +9 more
doaj   +1 more source

Conjugates of Small Molecule Drugs with Antibodies and Other Proteins

Biomedicines, 2014
Conjugates of small molecule drugs with antibodies (ADCs) and with other proteins (protein-drug conjugates, PDC) are used as a new class of targeted therapeutics combining the specificity of monoclonal antibodies (mAbs) and other proteins with potent ...
Yang Feng, Zhongyu Zhu, Weizao Chen, Ponraj Prabakaran, Kedan Lin, Dimiter S. Dimitrov   +5 more
doaj   +1 more source

High Impact: The Role of Promiscuous Binding Sites in Polypharmacology

Molecules, 2019
The literature focuses on drug promiscuity, which is a drug’s ability to bind to several targets, because it plays an essential role in polypharmacology.
Natacha Cerisier, Michel Petitjean, Leslie Regad, Quentin Bayard, Manon Réau, Anne Badel, Anne-Claude Camproux   +6 more
doaj   +1 more source

Chapter 1. Identification of Cellular Protein–Protein Interactions

, 2020
There are myriad interactions between proteins in the cell. The diversity and dynamics of the interactions make them challenging to chart, and a large variety of methods have been developed to tackle the task.
Sara Bergström Lind, Elias Tjärnhage, Tjärnhage, Elias,, Eszter Kassa, Kassa, Eszter,, Ivarsson, Ylva,, Benz, Caroline,, Bergström Lind, Sara,, Caroline Benz, Ylva Ivarsson   +9 more
core   +1 more source

Interaction of two strongly divergent archaellins stabilizes the structure of the Halorubrum archaellum

MicrobiologyOpen, 2020
Halophilic archaea from the genus Halorubrum possess two extraordinarily diverged archaellin genes, flaB1 and flaB2. To clarify roles for each archaellin, we compared two natural Halorubrum lacusprofundi strains: One of them contains both archaellin ...
Mikhail G. Pyatibratov, Alexey S. Syutkin, Tessa E. F. Quax, Tatjana N. Melnik, R. Thane Papke, Johann Peter Gogarten, Igor I. Kireev, Alexey K. Surin, Sergei N. Beznosov, Anna V. Galeva, Oleg V. Fedorov   +10 more
doaj   +1 more source

A time-resolved multi-omics atlas of Acanthamoeba castellanii encystment

Nature Communications, 2022
Encystment is a process that allows free-living and parasitic amoebae to survive in unfavorable environments. Here, Bernard et al. provide detailed insights into the early stages of encystment of Acanthamoeba castellanii by integrating RNA-Seq ...
Clément Bernard, Marie Locard-Paulet, Cyril Noël, Magalie Duchateau, Quentin Giai Gianetto, Bouziane Moumen, Thomas Rattei, Yann Hechard, Lars Juhl Jensen, Mariette Matondo, Ascel Samba-Louaka   +10 more
doaj   +1 more source

Protein-Ligand Interactions and Drug Design

, 2021
This detailed book collects modern and established computer-based methods aimed at addressing the drug discovery challenge from disparate perspectives by exploiting information on ligand-protein recognition.
Ballante, Flavio,
core   +1 more source

Protein-Protein Interactions in Plants [PDF]

Plant and Cell Physiology, 2012
The study of protein-protein interactions (PPIs) is essential to uncover unknown functions of proteins at the molecular level and to gain insight into complex cellular networks. Affinity purification and mass spectrometry (AP-MS), yeast two-hybrid, imaging approaches and numerous diverse databases have been developed as strategies to analyze PPIs.
openaire   +2 more sources

Computational Protein Design Force Field Optimization: A Negative Design Approach [PDF]

, 2007
An accurate force field is essential to computational protein design and protein folding studies. Proper force field tuning is problematic, however, due in part to the incomplete modeling of the unfolded state.
Alvizo, Oscar
core   +1 more source