Results 21 to 30 of about 7,753,904 (295)

HIV-1 Vpr activates host CRL4-DCAF1 E3 ligase to degrade histone deacetylase SIRT7

Virology Journal, 2021
Background Vpr is a virion-associated protein that is encoded by lentiviruses and serves to counteract intrinsic immunity factors that restrict infection.
Xiaohong Zhou, Christina Monnie, Maria DeLucia, Jinwoo Ahn   +3 more
doaj   +1 more source

Developing a peptide to disrupt cohesin head domain interactions

iScience, 2023
Summary: Cohesin mediates the 3-D structure of chromatin and is involved in maintaining genome stability and function. The cohesin core comprises Smc1 and Smc3, elongated-shaped proteins that dimerize through globular domains at their edges, called head ...
Maria Elias, Samar Gani, Yana Lerner, Katreen Yamin, Chen Tor, Adarsh Patel, Avi Matityahu, Moshe Dessau, Nir Qvit, Itay Onn   +9 more
doaj   +1 more source

Studying protein-protein interactions using peptide arrays [PDF]

, 2010
Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T., Rudiger, S.G.D., Sub Cellular Protein Chemistry, Rotem-Bamberger, S., Katz, C., Friedler, A., Levy-Beladev, L., Cellular Protein Chemistry   +7 more
core   +1 more source

Analysis of leukocyte membrane protein interactions using protein microarrays [PDF]

, 2005
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work
Foster-Cuevas, M, Letarte, Michelle, Deborah Hatherley, Foster-Cuevas, Mildred, Hatherley, D, Barclay, AN, Michelle Letarte, Saunders, Nigel, A Neil Barclay, Saunders, NJ, Hatherley, Deborah, Letarte, M, Barclay, Neil, Mildred Foster-Cuevas, Nigel J Saunders, Saunders, Nigel J, Voulgaraki, D, Despina Voulgaraki, Voulgaraki, Despina   +18 more
core   +1 more source

ProDGe: investigating protein-protein interactions at the domain level [PDF]

, 2011
An important goal of systems biology is the identification and investigation of known and predicted protein-protein interactions to obtain more information about new cellular pathways and processes.
Andreas Dräger, Clemens Wrzodek, Adrian Schröder, Adrian Schröder, Florian Mittag, Andreas Zell, Finja Büchel, Andreas Dräger, Finja Büchel   +8 more
core   +1 more source

Conjugates of Small Molecule Drugs with Antibodies and Other Proteins

Biomedicines, 2014
Conjugates of small molecule drugs with antibodies (ADCs) and with other proteins (protein-drug conjugates, PDC) are used as a new class of targeted therapeutics combining the specificity of monoclonal antibodies (mAbs) and other proteins with potent ...
Yang Feng, Zhongyu Zhu, Weizao Chen, Ponraj Prabakaran, Kedan Lin, Dimiter S. Dimitrov   +5 more
doaj   +1 more source

Aquaporin Protein-Protein Interactions [PDF]

International Journal of Molecular Sciences, 2017
Aquaporins are tetrameric membrane-bound channels that facilitate transport of water and other small solutes across cell membranes. In eukaryotes, they are frequently regulated by gating or trafficking, allowing for the cell to control membrane permeability in a specific manner.
Jennifer Roche, Susanna Törnroth-Horsefield   +1 more
openaire   +2 more sources

Prediction of protein-protein interaction types using association rule based classification [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Park et alBackground: Protein-protein interactions (PPI) can be classified according to their characteristics into, for example obligate or transient ...
José A Reyes, Kim, JW, Kim, S, Kim Ji, Sangsoo Kim, Gilbert, D, Park, SH, Reyes José A, Reyes, JA, Kim Sangsoo, Park Sung, Ji Kim, David R Gilbert, Gilbert David R, Sung Park   +14 more
core   +1 more source

CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]

, 2018
Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry, Hendershot, Linda M., Feige, Matthias J., Ineke Braakman, Matthias J. Feige, Braakman, Ineke, Cellular Protein Chemistry, Linda M. Hendershot   +7 more
core   +1 more source

High Impact: The Role of Promiscuous Binding Sites in Polypharmacology

Molecules, 2019
The literature focuses on drug promiscuity, which is a drug’s ability to bind to several targets, because it plays an essential role in polypharmacology.
Natacha Cerisier, Michel Petitjean, Leslie Regad, Quentin Bayard, Manon Réau, Anne Badel, Anne-Claude Camproux   +6 more
doaj   +1 more source