Results 21 to 30 of about 2,913,537 (285)

Inferring Domain–Domain Interactions From Protein–Protein Interactions [PDF]

Genome Research, 2002
The interaction between proteins is one of the most important features of protein functions. Behind protein–protein interactions there are protein domains interacting physically with one another to perform the necessary functions. Therefore, understanding protein interactions at the domain level gives a global view of the protein ...
Minghua, Deng, Shipra, Mehta, Fengzhu, Sun, Ting, Chen   +3 more
openaire   +2 more sources

PocketQuery: protein-protein interaction inhibitor starting points from protein-protein interaction structure [PDF]

Nucleic Acids Research, 2012
PocketQuery (http://pocketquery.csb.pitt.edu) is a web interface for exploring the properties of protein-protein interaction (PPI) interfaces with a focus on the discovery of promising starting points for small-molecule design. PocketQuery rapidly focuses attention on the key interacting residues of an interaction using a 'druggability' score that ...
Koes, David Ryan, Camacho, Carlos J.
openaire   +2 more sources

Antibody Aggregation: Insights from Sequence and Structure

Antibodies, 2016
Monoclonal antibodies (mAbs) are the fastest-growing biological therapeutics with important applications ranging from cancers, autoimmunity diseases and metabolic disorders to emerging infectious diseases.
Wei Li, Ponraj Prabakaran, Weizao Chen, Zhongyu Zhu, Yang Feng, Dimiter S. Dimitrov   +5 more
doaj   +1 more source

Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling

Nature Communications, 2022
SHP2 is an important human tyrosine phosphatase with key roles in cancer, immune responses and insulin signaling. Here, the authors explore its substrate recognition mechanism in molecular detail and uncover a complex regulatory mechanism for this enzyme 
András Zeke, Tamás Takács, Péter Sok, Krisztina Németh, Klára Kirsch, Péter Egri, Ádám Levente Póti, Isabel Bento, Gábor E. Tusnády, Attila Reményi   +9 more
doaj   +1 more source

Hot-spot analysis for drug discovery targeting protein-protein interactions [PDF]

, 2018
Introduction: Protein-protein interactions are important for biological processes and pathological situations, and are attractive targets for drug discovery. However, rational drug design targeting protein-protein interactions is still highly challenging.
Fernández-Recio, Juan, Rosell, Mireia
core   +2 more sources

Conjugates of Small Molecule Drugs with Antibodies and Other Proteins

Biomedicines, 2014
Conjugates of small molecule drugs with antibodies (ADCs) and with other proteins (protein-drug conjugates, PDC) are used as a new class of targeted therapeutics combining the specificity of monoclonal antibodies (mAbs) and other proteins with potent ...
Yang Feng, Zhongyu Zhu, Weizao Chen, Ponraj Prabakaran, Kedan Lin, Dimiter S. Dimitrov   +5 more
doaj   +1 more source

Protein-carbohydrate interactions during fertilization [PDF]

, 1998
Interaction between gametes during fertilization is at least in part regulated by carbohydrate moieties of the zona pellucida (ZP) and carbohydrate binding proteins of the sperm surface. This review focuses on the protein-carbohydrate interactions during
Kolle, S., Plendl, J., Sinowatz, Fred
core   +1 more source

Selective and potent proteomimetic inhibitors of intracellular protein–protein interactions [PDF]

, 2015
Inhibition of protein–protein interactions (PPIs) represents a major challenge in chemical biology and drug discovery. α-Helix mediated PPIs may be amenable to modulation using generic chemotypes, termed “proteomimetics”, which can be assembled in a ...
Azzarito, Barnard, Barth, Berg, Bieging, Borner, Bruncko, Bullock, Burslem, Campbell, Cao, Cheloha, Chipuk, González-Bulnes, Grigoryev, Guichard, Harker, Hoe, Kazi, Kussie, Lao, Lao, Lee, Liu, Long, Mathew, Milroy, Moldoveanu, Moran, Nevola, Oh, Orner, Pan, Saraogi, Saraogi, Schuler, Schäfer, Scott, Shangary, Spiegel, Stumpf, Thornberry, Uhrinova, Vassilev, Vu, Wade, Wells, Yao, Yin, Yin, Zhang, Zhang   +51 more
core   +4 more sources

High Impact: The Role of Promiscuous Binding Sites in Polypharmacology

Molecules, 2019
The literature focuses on drug promiscuity, which is a drug’s ability to bind to several targets, because it plays an essential role in polypharmacology.
Natacha Cerisier, Michel Petitjean, Leslie Regad, Quentin Bayard, Manon Réau, Anne Badel, Anne-Claude Camproux   +6 more
doaj   +1 more source

A time-resolved multi-omics atlas of Acanthamoeba castellanii encystment

Nature Communications, 2022
Encystment is a process that allows free-living and parasitic amoebae to survive in unfavorable environments. Here, Bernard et al. provide detailed insights into the early stages of encystment of Acanthamoeba castellanii by integrating RNA-Seq ...
Clément Bernard, Marie Locard-Paulet, Cyril Noël, Magalie Duchateau, Quentin Giai Gianetto, Bouziane Moumen, Thomas Rattei, Yann Hechard, Lars Juhl Jensen, Mariette Matondo, Ascel Samba-Louaka   +10 more
doaj   +1 more source