Results 21 to 30 of about 1,762,244 (262)

Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling

Nature Communications, 2022
SHP2 is an important human tyrosine phosphatase with key roles in cancer, immune responses and insulin signaling. Here, the authors explore its substrate recognition mechanism in molecular detail and uncover a complex regulatory mechanism for this enzyme 
András Zeke, Tamás Takács, Péter Sok, Krisztina Németh, Klára Kirsch, Péter Egri, Ádám Levente Póti, Isabel Bento, Gábor E. Tusnády, Attila Reményi   +9 more
doaj   +1 more source

Conjugates of Small Molecule Drugs with Antibodies and Other Proteins

Biomedicines, 2014
Conjugates of small molecule drugs with antibodies (ADCs) and with other proteins (protein-drug conjugates, PDC) are used as a new class of targeted therapeutics combining the specificity of monoclonal antibodies (mAbs) and other proteins with potent ...
Yang Feng, Zhongyu Zhu, Weizao Chen, Ponraj Prabakaran, Kedan Lin, Dimiter S. Dimitrov   +5 more
doaj   +1 more source

High Impact: The Role of Promiscuous Binding Sites in Polypharmacology

Molecules, 2019
The literature focuses on drug promiscuity, which is a drug’s ability to bind to several targets, because it plays an essential role in polypharmacology.
Natacha Cerisier, Michel Petitjean, Leslie Regad, Quentin Bayard, Manon Réau, Anne Badel, Anne-Claude Camproux   +6 more
doaj   +1 more source

Interaction of two strongly divergent archaellins stabilizes the structure of the Halorubrum archaellum

MicrobiologyOpen, 2020
Halophilic archaea from the genus Halorubrum possess two extraordinarily diverged archaellin genes, flaB1 and flaB2. To clarify roles for each archaellin, we compared two natural Halorubrum lacusprofundi strains: One of them contains both archaellin ...
Mikhail G. Pyatibratov, Alexey S. Syutkin, Tessa E. F. Quax, Tatjana N. Melnik, R. Thane Papke, Johann Peter Gogarten, Igor I. Kireev, Alexey K. Surin, Sergei N. Beznosov, Anna V. Galeva, Oleg V. Fedorov   +10 more
doaj   +1 more source

A time-resolved multi-omics atlas of Acanthamoeba castellanii encystment

Nature Communications, 2022
Encystment is a process that allows free-living and parasitic amoebae to survive in unfavorable environments. Here, Bernard et al. provide detailed insights into the early stages of encystment of Acanthamoeba castellanii by integrating RNA-Seq ...
Clément Bernard, Marie Locard-Paulet, Cyril Noël, Magalie Duchateau, Quentin Giai Gianetto, Bouziane Moumen, Thomas Rattei, Yann Hechard, Lars Juhl Jensen, Mariette Matondo, Ascel Samba-Louaka   +10 more
doaj   +1 more source

Protein-Protein Interactions in Plants [PDF]

Plant and Cell Physiology, 2012
The study of protein-protein interactions (PPIs) is essential to uncover unknown functions of proteins at the molecular level and to gain insight into complex cellular networks. Affinity purification and mass spectrometry (AP-MS), yeast two-hybrid, imaging approaches and numerous diverse databases have been developed as strategies to analyze PPIs.
openaire   +2 more sources

Hyperglycemia attenuates fibroblast contractility via suppression of TβRII receptor modulated α-smooth muscle actin expression

Biotechnology & Biotechnological Equipment, 2022
Nonhealing wounds are a common complication in patients suffering from diabetes with hyperglycemia being the most deteriorating factor for this serious pathological condition. Despite the great body of data, the molecular mechanisms by which high glucose
Alexandar Evangelatov, Georgi Georgiev, Borislav Arabadjiev, Stefan Pankov, Plamen Krastev, Albena Momchilova, Roumen Pankov   +6 more
doaj   +1 more source

PEPscan: A Broad Spectrum Approach for the Characterization of Protein-Binder Interactions?

Biomolecules, 2022
In a previous study, we have shown that PEPscan can provide a cheap and rapid means to identify candidate interfering peptides (IPs), i.e., peptides able to disrupt a target protein-protein interaction.
Angelita Rebollo, Louise Fliedel, Pierre Tuffery   +2 more
doaj   +1 more source

Quenching protein dynamics interferes with HIV capsid maturation

Nature Communications, 2017
The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to ...
Mingzhang Wang, Caitlin M. Quinn, Juan R. Perilla, Huilan Zhang, Randall Shirra Jr., Guangjin Hou, In-Ja Byeon, Christopher L. Suiter, Sherimay Ablan, Emiko Urano, Theodore J. Nitz, Christopher Aiken, Eric O. Freed, Peijun Zhang, Klaus Schulten, Angela M. Gronenborn, Tatyana Polenova   +16 more
doaj   +1 more source

Protein–Protein Interactions in Translesion Synthesis

Molecules, 2021
Translesion synthesis (TLS) is an error-prone DNA damage tolerance mechanism used by actively replicating cells to copy past DNA lesions and extend the primer strand.
Radha Charan Dash, Kyle Hadden
doaj   +1 more source