Results 21 to 30 of about 156,443 (294)
Intrinsic Disorder in the Human Tear Proteome. [PDF]
Invest Ophthalmol Vis Sci, 2023 PurposeWe aimed to characterize the proteome of human tears and assess for the presence of intrinsically disordered proteins (IDPs). IDPs, despite lacking a rigid three-dimensional structure, maintain biological functionality and could shed light on the ...
Taylor Gonzalez DJ +8 more
europepmc +2 more sources
CAID prediction portal: a comprehensive service for predicting intrinsic disorder and binding regions in proteins. [PDF]
Nucleic Acids Res, 2023 Intrinsic disorder (ID) in proteins is well-established in structural biology, with increasing evidence for its involvement in essential biological processes.
Del Conte A +7 more
europepmc +2 more sources
Evolution of Intrinsic Disorder in Protein Loops. [PDF]
Life (Basel), 2023 Intrinsic disorder accounts for the flexibility of protein loops, molecular building blocks that are largely responsible for the processes and molecular functions of the living world.
Mughal F, Caetano-Anollés G.
europepmc +2 more sources
Biophysical Reviews, 2022 Many different intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases. These types of proteins including amyloid-β, tau, α-synuclein, CHCHD2, CHCHD10, and G-protein coupled receptors are increasingly becoming evaluated as potential drug targets in the pharmaceutical-based ...
Orkid Coskuner-Weber +2 more
openaire +4 more sources
Intrinsic disorder in PRAME and its role in uveal melanoma. [PDF]
Cell Commun Signal, 2023 Introduction The PReferentially expressed Antigen in MElanoma (PRAME) protein has been shown to be an independent biomarker for increased risk of metastasis in Class 1 uveal melanomas (UM).
Antonietti M +6 more
europepmc +2 more sources
NMR illuminates intrinsic disorder. [PDF]
Curr Opin Struct Biol, 2021 Nuclear magnetic resonance (NMR) has long been instrumental in the characterization of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs). This method continues to offer rich insights into the nature of IDPs in solution, especially in combination with other biophysical methods such as small-angle scattering, single ...
Dyson HJ, Wright PE.
europepmc +3 more sources
Protein flexibility and intrinsic disorder [PDF]
Protein Science, 2004 AbstractComparisons were made among four categories of protein flexibility: (1) low‐B‐factor ordered regions, (2) high‐B‐factor ordered regions, (3) short disordered regions, and (4) long disordered regions. Amino acid compositions of the four categories were found to be significantly different from each other, with high‐B‐factor ordered and short ...
Radivojac, P. +7 more
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Databases for intrinsically disordered proteins [PDF]
Acta Crystallographica Section D Structural Biology, 2022 Intrinsically disordered regions (IDRs) lacking a fixed three-dimensional protein structure are widespread and play a central role in cell regulation. Only a small fraction of IDRs have been functionally characterized, with heterogeneous experimental evidence that is largely buried in the literature.
Piovesan, Damiano +3 more
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IndiSPENsable for X Chromosome Inactivation and Gene Silencing
Epigenomes, 2023 For about 30 years, SPEN has been the subject of research in many different fields due to its variety of functions and its conservation throughout a wide spectrum of species, like worms, arthropods, and vertebrates.
Corinne Kaufmann, Anton Wutz
doaj +1 more source
Intrinsically disordered proteins and biomineralization [PDF]
Matrix Biology, 2016 In vertebrates and invertebrates, biomineralization is controlled by the cell and the proteins they produce. A large number of these proteins are intrinsically disordered, gaining some secondary structure when they interact with their binding partners.
Adele L, Boskey +1 more
openaire +2 more sources