Results 21 to 30 of about 2,160,956 (299)
Biophysical Reviews, 2022 Many different intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases. These types of proteins including amyloid-β, tau, α-synuclein, CHCHD2, CHCHD10, and G-protein coupled receptors are increasingly becoming evaluated as potential drug targets in the pharmaceutical-based ...
Orkid Coskuner-Weber +2 more
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DEPICTER: Intrinsic Disorder and Disorder Function Prediction Server [PDF]
, 2020 Computational predictions of the intrinsic disorder and its functions are instrumental to facilitate annotation for the millions of unannotated proteins.
Lukasz Kurgan +11 more
core +1 more source
Protein flexibility and intrinsic disorder [PDF]
Protein Science, 2004 AbstractComparisons were made among four categories of protein flexibility: (1) low‐B‐factor ordered regions, (2) high‐B‐factor ordered regions, (3) short disordered regions, and (4) long disordered regions. Amino acid compositions of the four categories were found to be significantly different from each other, with high‐B‐factor ordered and short ...
Radivojac, P. +7 more
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Intrinsically disordered proteins and biomineralization [PDF]
Matrix Biology, 2016 In vertebrates and invertebrates, biomineralization is controlled by the cell and the proteins they produce. A large number of these proteins are intrinsically disordered, gaining some secondary structure when they interact with their binding partners.
Adele L, Boskey +1 more
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Databases for intrinsically disordered proteins [PDF]
Acta Crystallographica Section D Structural Biology, 2022 Intrinsically disordered regions (IDRs) lacking a fixed three-dimensional protein structure are widespread and play a central role in cell regulation. Only a small fraction of IDRs have been functionally characterized, with heterogeneous experimental evidence that is largely buried in the literature.
Piovesan, Damiano +3 more
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NMR illuminates intrinsic disorder. [PDF]
Curr Opin Struct Biol, 2021 Nuclear magnetic resonance (NMR) has long been instrumental in the characterization of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs). This method continues to offer rich insights into the nature of IDPs in solution, especially in combination with other biophysical methods such as small-angle scattering, single ...
Dyson HJ, Wright PE.
europepmc +3 more sources
Frontiers in Genetics, 2020 Pathogen infection triggers extensive reprogramming of the plant transcriptome, including numerous genes the function of which is unknown. Due to their wide taxonomic distribution, genes encoding proteins with Domains of Unknown Function (DUFs) activated
Marie Didelon +4 more
doaj +1 more source
WRKYs in Durum wheat: Intrinsic disorder and interactions [PDF]
Network Biology, 2022 The WRKY transcription factors are involved in a range of biological processes in plants, including the response to biotic and abiotic stresses and plant immunity.
Mouna Choura, Faical Brini
doaj
Rapid prediction and analysis of protein intrinsic disorder. [PDF]
Protein Sci, 2022 Protein intrinsic disorder is found in all kingdoms of life and is known to underpin numerous physiological and pathological processes. Computational methods play an important role in characterizing and identifying intrinsically disordered proteins and ...
Dayhoff GW, Uversky VN.
europepmc +2 more sources
CAID prediction portal: a comprehensive service for predicting intrinsic disorder and binding regions in proteins. [PDF]
Nucleic Acids Res, 2023 Intrinsic disorder (ID) in proteins is well-established in structural biology, with increasing evidence for its involvement in essential biological processes.
Del Conte A +7 more
europepmc +2 more sources