Results 41 to 50 of about 2,160,956 (299)
Intrinsically Disordered Proteins: An Overview
International Journal of Molecular Sciences, 2022 Many proteins and protein segments cannot attain a single stable three-dimensional structure under physiological conditions; instead, they adopt multiple interconverting conformational states. Such intrinsically disordered proteins or protein segments are highly abundant across proteomes, and are involved in various effector functions.
Rakesh Trivedi +1 more
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Biomolecules, 2023 LC8, a ubiquitous and highly conserved hub protein, binds over 100 proteins involved in numerous cellular functions, including cell death, signaling, tumor suppression, and viral infection. LC8 binds intrinsically disordered proteins (IDPs), and although
Douglas R. Walker +8 more
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The Nucleocapsid of Paramyxoviruses: Structure and Function of an Encapsidated Template
Viruses, 2021 Viruses of the Paramyxoviridae family share a common and complex molecular machinery for transcribing and replicating their genomes. Their non-segmented, negative-strand RNA genome is encased in a tight homopolymer of viral nucleoproteins (N).
Louis-Marie Bloyet
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Biomolecules, 2022 Rabies is a neurological disease that causes between 40,000 and 70,000 deaths every year. Once a rabies patient has become symptomatic, there is no effective treatment for the illness, and in unvaccinated individuals, the case-fatality rate of rabies is ...
Surya Dhulipala, Vladimir N. Uversky
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Abundance of intrinsic disorder in SV-IV, a multifunctional androgen-dependent protein secreted from rat seminal vesicle [PDF]
, 2007 The potent immunomodulatory, anti-inflammatory and procoagulant properties of the protein no. 4 secreted from the rat seminal vesicle epithelium (SV-IV) have been previously found to be modulated by a supramolecular monomer-trimer ...
Silvia Vilasi +4 more
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Compositional Bias of Intrinsically Disordered Proteins and Regions and Their Predictions
Biomolecules, 2022 Intrinsically disordered regions (IDRs) carry out many cellular functions and vary in length and placement in protein sequences. This diversity leads to variations in the underlying compositional biases, which were demonstrated for the short vs.
Bi Zhao, Lukasz Kurgan
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Cells, 2022 Cyclin-dependent kinases (CDKs) are presumed to control the cell cycle by phosphorylating a large number of proteins involved in S-phase and mitosis, two mechanistically disparate biological processes.
Liliana Krasinska, Daniel Fisher
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Modeling intrinsic spirituality in gambling disorder
, 2020 Background: Spirituality is related to an individual’s relationship with a Transcendent Being or Ultimate Reality, which may contribute to salutary human experience and serve as a motive for attitudes and behaviors. In contrast to studies in the field of
Moretta T. +2 more
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Structural disorder and the loss of RNA homeostasis in aging and neurodegenerative disease
Frontiers in Genetics, 2013 Whereas many cases of neurodegenerative disease feature the abnormal accumulationof protein, an abundance of recent literature highlights loss of RNA homeostasis as aubiquitous and central feature of pathological states.
Douglas eGray +3 more
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Phase separation in innate immune response and inflammation-related diseases
Frontiers in Immunology, 2023 Inflammation induced by nonspecific pathogenic or endogenous danger signals is an essential mechanism of innate immune response. The innate immune responses are rapidly triggered by conserved germline-encoded receptors that recognize broad patterns ...
Huihui Ma +6 more
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