Results 41 to 50 of about 1,811,289 (287)

Concentrating on intrinsic disorder [PDF]

Nature Reviews Molecular Cell Biology, 2018
Many eukaryotic proteins, including key transcription regulators, contain intrinsically disordered regions (IDRs), which serve as flexible interaction platforms. The molecular understanding of IDR-based interactions is now emerging, providing new insights into how IDRs promote protein compartmentalization and/or phase separation and how these processes
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The N-terminal cytoplasmic region of NCBE displays features of an intrinsic disordered structure and represents a novel target for specific drug screening

Frontiers in Physiology, 2013
The sodium dependent bicarbonate transporter NCBE/NBCn2 is predominantly expressed in the central nervous system (CNS). The highest protein abundance is found in the choroid plexus.
Kaare eBjerregaard-Andersen, Kaare eBjerregaard-Andersen, Harmonie ePerdreau-Dahl, Hanne eGuldsten, Jeppe ePraetorius, Jan Kristian Jensen, Jens Preben eMorth, Jens Preben eMorth   +7 more
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Abundance of intrinsic disorder in SV-IV, a multifunctional androgen-dependent protein secreted from rat seminal vesicle [PDF]

, 2007
The potent immunomodulatory, anti-inflammatory and procoagulant properties of the protein no. 4 secreted from the rat seminal vesicle epithelium (SV-IV) have been previously found to be modulated by a supramolecular monomer-trimer ...
Silvia Vilasi, Raffaele Ragone, Silvia Vilasi, AND RAGONE R., VILASI, SILVIA   +4 more
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Critical assessment of protein intrinsic disorder prediction

, 2021
Intrinsically disordered proteins, defying the traditional protein structure–function paradigm, are a challenge to study experimentally. Because a large part of our knowledge rests on computational predictions, it is crucial that their accuracy is high ...
Necci, M, Iqbal, S, Vendruscolo, M, Zhou, Y, Litfin, T, Paliwal, K, Walsh, I, Wang, C, Hanson, J, Raimondi, D, Hoque, MT, Sormanni, P, et al., Piovesan, D, Sharma, R   +14 more
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Intrinsically disordered proteins and biomineralization [PDF]

Matrix Biology, 2016
In vertebrates and invertebrates, biomineralization is controlled by the cell and the proteins they produce. A large number of these proteins are intrinsically disordered, gaining some secondary structure when they interact with their binding partners.
Adele L, Boskey, Eduardo, Villarreal-Ramirez   +1 more
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Abundance Imparts Evolutionary Constraints of Similar Magnitude on the Buried, Surface, and Disordered Regions of Proteins

Frontiers in Molecular Biosciences, 2021
An understanding of the forces shaping protein conservation is key, both for the fundamental knowledge it represents and to allow for optimal use of evolutionary information in practical applications. Sequence conservation is typically examined at one of
Benjamin Dubreuil, Emmanuel D. Levy
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Functional Diversity and Structural Disorder in the Human Ubiquitination Pathway [PDF]

, 2013
The ubiquitin-proteasome system plays a central role in cellular regulation and protein quality control (PQC). The system is built as a pyramid of increasing complexity, with two E1 (ubiquitin activating), few dozen E2 (ubiquitin conjugating) and several
Mainak Guharoy, Rita Pancsa (173029), Pallab Bhowmick, Tompa, Péter, Pallab Bhowmick (416342), Peter Tompa, Bhowmick, Pallab, Pancsa Rita, Guharoy Mainak, Bhowmick Pallab, Tompa Peter, Guharoy, Majnak, Mainak Guharoy (416343), Peter Tompa (38445), Rita Pancsa, Pancsa, Rita   +15 more
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Inherent structural disorder and dimerisation of murine norovirus NS1-2 protein [PDF]

, 2012
Human noroviruses are highly infectious viruses that cause the majority of acute, non-bacterial epidemic gastroenteritis cases worldwide. The first open reading frame of the norovirus RNA genome encodes for a polyprotein that is cleaved by the viral ...
Krause Kurt L., Luckner, Sylvia R., Krause, Kurt L., Luckner Sylvia R., Lambden, Paul R., Sylvia R Luckner, Kurt L Krause, Clarke, Ian N., Paul R Lambden, Baker, Estelle S., Ian N Clarke, Baker Estelle S., Estelle S Baker, Ward Vernon K., Lambden Paul R., Ward, Vernon K., Clarke Ian N., Vernon K Ward   +17 more
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DEPICTER: Intrinsic Disorder and Disorder Function Prediction Server

, 2020
Computational predictions of the intrinsic disorder and its functions are instrumental to facilitate annotation for the millions of unannotated proteins.
Lukasz Kurgan, Katuwawala, Akila, Kurgan, Lukasz, Zhou, Yaoqi, Hanson, Jack, Yaoqi Zhou, Amita Barik, Kuldip Paliwal, Paliwal, Kuldip, Akila Katuwawala, Jack Hanson, Barik, Amita   +11 more
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Intrinsically Disordered Proteins: An Overview

International Journal of Molecular Sciences, 2022
Many proteins and protein segments cannot attain a single stable three-dimensional structure under physiological conditions; instead, they adopt multiple interconverting conformational states. Such intrinsically disordered proteins or protein segments are highly abundant across proteomes, and are involved in various effector functions.
Rakesh Trivedi, Hampapathalu Adimurthy Nagarajaram   +1 more
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