Results 41 to 50 of about 156,443 (294)

Intrinsically Disordered Proteins: An Overview

International Journal of Molecular Sciences, 2022
Many proteins and protein segments cannot attain a single stable three-dimensional structure under physiological conditions; instead, they adopt multiple interconverting conformational states. Such intrinsically disordered proteins or protein segments are highly abundant across proteomes, and are involved in various effector functions.
Rakesh Trivedi, Hampapathalu Adimurthy Nagarajaram   +1 more
openaire   +2 more sources

Critical assessment of protein intrinsic disorder prediction

, 2021
Intrinsically disordered proteins, defying the traditional protein structure–function paradigm, are a challenge to study experimentally. Because a large part of our knowledge rests on computational predictions, it is crucial that their accuracy is high ...
Necci, M, Iqbal, S, Vendruscolo, M, Zhou, Y, Litfin, T, Paliwal, K, Walsh, I, Wang, C, Hanson, J, Raimondi, D, Hoque, MT, Sormanni, P, et al., Piovesan, D, Sharma, R   +14 more
core   +1 more source

The N-terminal cytoplasmic region of NCBE displays features of an intrinsic disordered structure and represents a novel target for specific drug screening

Frontiers in Physiology, 2013
The sodium dependent bicarbonate transporter NCBE/NBCn2 is predominantly expressed in the central nervous system (CNS). The highest protein abundance is found in the choroid plexus.
Kaare eBjerregaard-Andersen, Kaare eBjerregaard-Andersen, Harmonie ePerdreau-Dahl, Hanne eGuldsten, Jeppe ePraetorius, Jan Kristian Jensen, Jens Preben eMorth, Jens Preben eMorth   +7 more
doaj   +1 more source

Linker Length Drives Heterogeneity of Multivalent Complexes of Hub Protein LC8 and Transcription Factor ASCIZ

Biomolecules, 2023
LC8, a ubiquitous and highly conserved hub protein, binds over 100 proteins involved in numerous cellular functions, including cell death, signaling, tumor suppression, and viral infection. LC8 binds intrinsically disordered proteins (IDPs), and although
Douglas R. Walker, Kayla A. Jara, Amber D. Rolland, Coban Brooks, Wendy Hare, Andrew K. Swansiger, Patrick N. Reardon, James S. Prell, Elisar J. Barbar   +8 more
doaj   +1 more source

DEPICTER: Intrinsic Disorder and Disorder Function Prediction Server

, 2020
Computational predictions of the intrinsic disorder and its functions are instrumental to facilitate annotation for the millions of unannotated proteins.
Lukasz Kurgan, Katuwawala, Akila, Kurgan, Lukasz, Zhou, Yaoqi, Hanson, Jack, Yaoqi Zhou, Amita Barik, Kuldip Paliwal, Paliwal, Kuldip, Akila Katuwawala, Jack Hanson, Barik, Amita   +11 more
core   +1 more source

The Nucleocapsid of Paramyxoviruses: Structure and Function of an Encapsidated Template

Viruses, 2021
Viruses of the Paramyxoviridae family share a common and complex molecular machinery for transcribing and replicating their genomes. Their non-segmented, negative-strand RNA genome is encased in a tight homopolymer of viral nucleoproteins (N).
Louis-Marie Bloyet
doaj   +1 more source

Looking at the Pathogenesis of the Rabies Lyssavirus Strain Pasteur Vaccins through a Prism of the Disorder-Based Bioinformatics

Biomolecules, 2022
Rabies is a neurological disease that causes between 40,000 and 70,000 deaths every year. Once a rabies patient has become symptomatic, there is no effective treatment for the illness, and in unvaccinated individuals, the case-fatality rate of rabies is ...
Surya Dhulipala, Vladimir N. Uversky
doaj   +1 more source

A geometric network model of intrinsic grey-matter connectivity of the human brain [PDF]

, 2015
Network science provides a general framework for analysing the large-scale brain networks that naturally arise from modern neuroimaging studies, and a key goal in theoretical neuro- science is to understand the extent to which these neural ...
Kaiser, M, Crofts, JJ, Han, CE, Lo, Yi-Ping, O'Dea, Reuben D., Lo, Y-P, Han, Cheol E., Kaiser, Marcus, O’Dea, R, Crofts, Jonathan J.   +9 more
core   +1 more source

Compositional Bias of Intrinsically Disordered Proteins and Regions and Their Predictions

Biomolecules, 2022
Intrinsically disordered regions (IDRs) carry out many cellular functions and vary in length and placement in protein sequences. This diversity leads to variations in the underlying compositional biases, which were demonstrated for the short vs.
Bi Zhao, Lukasz Kurgan
doaj   +1 more source

A Mechanistic Model for Cell Cycle Control in Which CDKs Act as Switches of Disordered Protein Phase Separation

Cells, 2022
Cyclin-dependent kinases (CDKs) are presumed to control the cell cycle by phosphorylating a large number of proteins involved in S-phase and mitosis, two mechanistically disparate biological processes.
Liliana Krasinska, Daniel Fisher
doaj   +1 more source