Results 51 to 60 of about 156,443 (294)
Structural disorder and the loss of RNA homeostasis in aging and neurodegenerative disease
Frontiers in Genetics, 2013 Whereas many cases of neurodegenerative disease feature the abnormal accumulationof protein, an abundance of recent literature highlights loss of RNA homeostasis as aubiquitous and central feature of pathological states.
Douglas eGray +3 more
doaj +1 more source
Phase separation in innate immune response and inflammation-related diseases
Frontiers in Immunology, 2023 Inflammation induced by nonspecific pathogenic or endogenous danger signals is an essential mechanism of innate immune response. The innate immune responses are rapidly triggered by conserved germline-encoded receptors that recognize broad patterns ...
Huihui Ma +6 more
doaj +1 more source
Exon-phase symmetry and intrinsic structural disorder promote modular evolution in the human genome
, 2013 A key signature of module exchange in the genome is phase symmetry of exons, suggestive of exon shuffling events that occurred without disrupting translation reading frame.
Kalmár, Lajos +2 more
core +1 more source
Biomolecules, 2020 With over 60 disorder predictors, users need help navigating the predictor selection task. We review 28 surveys of disorder predictors, showing that only 11 include assessment of predictive performance.
Akila Katuwawala, Lukasz Kurgan
doaj +1 more source
Intrinsic disorder in the kinesin superfamily
Biophysical Reviews, 2012 Kinesin molecular motors perform a myriad of intracellular transport functions. While their mechanochemical mechanisms are well understood and well-conserved throughout the superfamily, the cargo-binding and regulatory mechanisms governing the activity of kinesins are highly diverse and in general, are incompletely characterized.
Mark A, Seeger, Sarah E, Rice
openaire +3 more sources
Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders [PDF]
Frontiers in Aging Neuroscience, 2015 The recent years have witnessed a rise in the number of intrinsically disordered proteins (IDPs), also known as hybrid proteins, which possess both structured domains and biologically important intrinsically disordered protein regions (IDPRs). These proteins challenge the “one sequence—one structure—one function” concept by demonstrating that the lack ...
Vladimir N. Uversky +3 more
openaire +4 more sources
eLife, 2017 Scaffolding the calcium/calmodulin-dependent phosphatase 2B (PP2B, calcineurin) focuses and insulates termination of local second messenger responses.
Patrick J Nygren +9 more
doaj +1 more source
Super Spy variants implicate flexibility in chaperone action
eLife, 2014 Experimental study of the role of disorder in protein function is challenging. It has been proposed that proteins utilize disordered regions in the adaptive recognition of their various binding partners.
Shu Quan +8 more
doaj +1 more source
Exploring Intrinsic Disorder in Human Synucleins and Associated Proteins. [PDF]
Int J Mol SciIn this work, we explored the intrinsic disorder status of the three members of the synuclein family of proteins—α-, β-, and γ-synucleins—and showed that although all three human synucleins are highly disordered, the highest ...
Venati SR, Uversky VN.
europepmc +2 more sources
Intrinsically Disordered Proteins in Neurodegeneration [PDF]
Biophysical Journal, 2016 Intrinsically disordered proteins (IDPs) have gained wide recognition due to their versatile roles in cell physiology and pathology. A large repertoire of IDPs has been implicated in numerous diseases, making them potential targets for therapeutic intervention.
openaire +2 more sources