Results 21 to 30 of about 41,661 (301)

Influence of sequence changes and environment on intrinsically disordered proteins. [PDF]

PLoS Computational Biology, 2009
Many large-scale studies on intrinsically disordered proteins are implicitly based on the structural models deposited in the Protein Data Bank. Yet, the static nature of deposited models supplies little insight into variation of protein structure and ...
Amrita Mohan, Vladimir N Uversky, Predrag Radivojac   +2 more
doaj   +1 more source

MobiDB: intrinsically disordered proteins in 2021 [PDF]

Nucleic Acids Research, 2020
AbstractThe MobiDB database (URL: https://mobidb.org/) provides predictions and annotations for intrinsically disordered proteins. Here, we report recent developments implemented in MobiDB version 4, regarding the database format, with novel types of annotations and an improved update process.
Damiano Piovesan, Marco Necci, Nahuel Escobedo, Alexander Miguel Monzon, András Hatos, Ivan Micetic, Federica Quaglia, Lisanna Paladin, Pathmanaban Ramasamy, Zsuzsanna Dosztányi, Wim F. Vranken, Norman E. Davey, Gustavo D. Parisi, Mónika Fuxreiter, Silvio C. E. Tosatto   +14 more
openaire   +8 more sources

Fairy tails: Flexibility and function of intrinsically disordered extensions in the photosynthetic world

Frontiers in Molecular Biosciences, 2015
Intrinsically Disordered Proteins (IDPs), or protein fragments also called Intrinsically Disordered Regions (IDRs), display high flexibility as the result of their amino acid composition. They can adopt multiple roles.
Gabriel eThieulin-Pardo, Luisana eAvilan, Mila eKojadinovic, Brigitte eGontero   +3 more
doaj   +1 more source

Machine-learning analysis of intrinsically disordered proteins identifies key factors that contribute to neurodegeneration-related aggregation

Frontiers in Aging Neuroscience, 2022
Protein structure is determined by the amino acid sequence and a variety of post-translational modifications, and provides the basis for physiological properties.
Akshatha Ganne, Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, Srinivas Ayyadevara, Srinivas Ayyadevara, Robert J. Shmookler Reis, Robert J. Shmookler Reis, Robert J. Shmookler Reis   +7 more
doaj   +1 more source

NeProc predicts binding segments in intrinsically disordered regions without learning binding region sequences

Biophysics and Physicobiology, 2020
Intrinsically disordered proteins are those proteins with intrinsically disordered regions. One of the unique characteristics of intrinsically disordered proteins is the existence of functional segments in intrinsically dis­ordered regions.
Hiroto Anbo, Hiroki Amagai, Satoshi Fukuchi   +2 more
doaj   +1 more source

Intrinsic disorder in protein interactions: insights from a comprehensive structural analysis. [PDF]

PLoS Computational Biology, 2009
We perform a large-scale study of intrinsically disordered regions in proteins and protein complexes using a non-redundant set of hundreds of different protein complexes.
Jessica H Fong, Benjamin A Shoemaker, Sergiy O Garbuzynskiy, Michail Y Lobanov, Oxana V Galzitskaya, Anna R Panchenko   +5 more
doaj   +1 more source

Intrinsic disorder in putative protein sequences [PDF]

Proteome Science, 2011
Intrinsically disordered proteins (IDPs) and regions (IDRs) perform a variety of crucial biological functions despite lacking stable tertiary structure under physiological conditions in vitro. State-of-the-art sequence-based predictors of intrinsic disorder are achieving per-residue accuracies over 80%.
Uros Midic, Zoran Obradovic
openaire   +3 more sources

Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology. [PDF]

PLoS ONE, 2013
The abundance and potential functional roles of intrinsically disordered regions in aquaporin-4, Kir4.1, a dystrophin isoforms Dp71, α-1 syntrophin, and α-dystrobrevin; i.e., proteins constituting the functional core of the astrocytic dystrophin ...
Insung Na, Derek Redmon, Markus Kopa, Yiru Qin, Bin Xue, Vladimir N Uversky   +5 more
doaj   +1 more source

Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions

Molecules, 2017
Intrinsically disordered proteins and proteins with intrinsically disordered regions have been shown to be highly prevalent in disease. Furthermore, disease-causing expansions of the regions containing tandem amino acid repeats often push repetitive ...
April L. Darling, Vladimir N. Uversky
doaj   +1 more source

Mediator subunit Med15 dictates the conserved “fuzzy” binding mechanism of yeast transcription activators Gal4 and Gcn4

Nature Communications, 2021
The intrinsically disordered acidic activation domain (AD) of the yeast transcription factor Gal4 acts through binding to the Med15 subunit of the Mediator complex.
Lisa M. Tuttle, Derek Pacheco, Linda Warfield, Damien B. Wilburn, Steven Hahn, Rachel E. Klevit   +5 more
doaj   +1 more source