Results 151 to 160 of about 7,902,914 (332)

Conformation and Dynamics of the Troponin I C-Terminal Domain: Combining Single-Molecule and Computational Approaches for a Disordered Protein Region

Journal of the American Chemical Society, 2015
In recent years, single-molecule Förster resonance energy transfer (smFRET) has emerged as a critical and flexible tool in structural biology, particularly in the study of highly dynamic regions and molecular assemblies.
L. Metskas, Elizabeth Rhoades
semanticscholar   +1 more source

EPR in protein science : intrinsically disordered proteins

, 2011
Intrinsically disordered proteins (IDPs) form a unique protein category characterized by the absence of a well-defined structure and by remarkable conformational flexibility.
Drescher, Malte, Malte Drescher
core   +1 more source

Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal, Gowtham Yerneni, Kim J. Griffin, Nicolas Thompson, Ken Uchino, Irene Katzan, Dolora Wisco, Abeer Farrag, Jayashree Sundarajan, Andrew Russman, M. Shazam Hussain   +10 more
wiley   +1 more source

Dynamic networks of intrinsically disordered regions in nuclear proteins

Biophysics and Physicobiology
Chromatin in the eukaryotic nucleus is organized into transcriptionally active euchromatin and transcriptionally silent heterochromatin. Its fundamental unit, the nucleosome, consists of two copies each of histones H2A, H2B, H3, and H4 wrapped by ~145 base pairs of DNA, flanked by linker-DNA that binds linker-histone H1 to form a chromatosome.
openaire   +2 more sources

ATP‐Mediated Bidirectional Communication Between Natural and Artificial Cells for Controlled Bioreactions

Advanced Functional Materials, EarlyView.
Establishment of bidirectional communication behavior between natural and artificial cells. The first type of communication from natural dendritic cells to artificial polymeric cells was achieved via ATP release after cell lysis. The released ATP was taken up via gated UV‐controlled permeability increase of the polymeric membrane for performing ...
Ilona Kalte, Tsvetomir Ivanov, Leonhard Seufert, Shoupeng Cao, Lucas Caire da Silva, Volker Mailänder, Katharina Landfester   +6 more
wiley   +1 more source

The P granule antibody KT3 recognizes epitopes in both PGL-1 and PGL-3

microPublication Biology
The KT3 antibody is a commercially available antibody that recognizes the P granule protein PGL-3 (Takeda et al., 2008). Using immunostaining and western blotting of purified peptide fragments, we show that KT3 recognizes both PGL-3 and its paralog PGL-1,
Brennan M Danlasky, Mario Martinez, Madeline Cassani, Devavrat Bodas, Andrea Putnam, Geraldine Seydoux   +5 more
doaj   +1 more source

A Dimerization Function in the Intrinsically Disordered N-Terminal Region of Src

Cell Reports, 2018
Summary: The mode of regulation of Src kinases has been elucidated by crystallographic studies identifying conserved structured protein modules involved in an orderly set of intramolecular associations and ligand interactions.
Danislav S. Spassov, Ana Ruiz-Saenz, Amit Piple, Mark M. Moasser   +3 more
doaj   +1 more source

Deciphering the mechanisms of binding induced folding at nearly atomic resolution : The Φ value analysis applied to IDPs

, 2014
The Φ value analysis is a method to analyze the structure of metastable states in reaction pathways. Such a methodology is based on the quantitative analysis of the effect of point mutations on the kinetics and thermodynamics of the probed reaction.
Gianni, Stefano, Jemth, Per, Dogan, Jakob, Dogan, Jakob,, Jemth, Per,   +4 more
core   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

The repeat region of cortactin is intrinsically disordered in solution

, 2017
The multi-domain protein, cortactin, contains a 37-residue repeating motif that binds to actin filaments. This cortactin repeat region comprises 6½ similar copies of the motif and binds actin filaments.
Yeqing Tao, Alexander N. Scherer, Titus J. Boggon, Alan G. Marshall, Anthony J. Koleske, Xiaofeng Li, TuKiet T. Lam, James W. Murphy   +7 more
core   +1 more source