Results 181 to 190 of about 29,703 (304)

No Time to Fold: Intrinsically Disordered Microproteins in Action. [PDF]

Biochemistry
Chen T, Cao K, Martinez TF.
europepmc   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Intrinsically disordered regions facilitate Mlp1-Nab2 recognition in mRNA quality control. [PDF]

Nucleus
Soheilypour M, Peyro M, Shams H, Mofrad MRK.   +3 more
europepmc   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

CHARACTERIZATION OF ASXL2 AS AN INTRINSICALLY DISORDERED PROTEIN

, 2013
During development and differentiation, the transcription regulation plays an important rule. The Polycomb Group (PcG) and the Trithorax Group (TrxG) proteins are two protein families; they act by forming multiprotein complexes that regulate ...
Chen, Po-tao
core  

The Conservation and Classification of Intrinsically Disordered Regions in Proteins

The Conservation and Classification of Intrinsically Disordered Regions in Proteins
学位の種別: 課程博士 審査委員会委員 : (主査)東京大学教授 中井 謙太, 東京大学教授 菅野 純夫, 東京大学教授 津本 浩平, 東京大学准教授 尾山 大明, 東京大学准教授 渋谷 ...
openaire  

Structuring Disorder via Supervised Molecular Dynamics: Uncovering Arginine-Glycine-Glycine-Mediated Ribonucleic Acid-Intrinsically Disordered Region Recognition Mechanisms. [PDF]

J Chem Inf Model
Novello G, Dodaro A, Strascia CC, Menin S, Sturlese M, Salmaso V, Moro S.   +6 more
europepmc   +1 more source

Machine‐Learning Microfluidic Minute‐Scale Microorganism Metrics Monitoring(M6)

Advanced Science, EarlyView.
ABSTRACT On‐site monitoring of microorganisms remains challenging because of low concentrations, strong background interference, and dynamic aerosol diffusion, particularly for aerosol‐transmitted pathogens. Here, we report a rapid detection platform that integrates a Puri‐focusing microfluidic chip, electrochemical impedance spectroscopy (EIS), and ...
Ning Yang, Jiahao Ding, Si Chen, Lijie Yan, Shichao Ding, Lavonda Li, Junyi Sun, Haodong Liu, Tongge Li, Ning Liu, Mingji Wei, Xiaoyong Zhu, Xiaobo Zou, Shouqi Yuan, Xingcai Zhang   +14 more
wiley   +1 more source

Sequence-encoded differences in the conformational ensembles of CITED transcriptional activation domains impact coactivator binding. [PDF]

Protein Sci
Do TU, Kraft EJ, Chappell GF, Parnham S, Berlow RB.   +4 more
europepmc   +1 more source

Bioprinted Tumor Microenvironment Models Reveal Immune Evasion and Guide CAR‐NK Therapeutic Strategies

Advanced Science, EarlyView.
This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim, Seona Jo, In‐Hwan Jang, Yu‐Jin Kim, Youngmee Jung, Junhyoung Ahn, Hyungjun Lim, Jae Jong Lee, Kangwon Lee, Tae‐Don Kim, Su A Park   +10 more
wiley   +1 more source