Results 231 to 240 of about 7,902,914 (332)

Self-recognition by an intrinsically disordered protein

The intrinsically disordered translocation domain (T-domain) of the protein antibiotic colicin N binds to periplasmic receptors of target Escherichia coli cells in order to penetrate their inner membranes.
Boetzel R, Chalton DA, Lewin A, Lakey JH, Moore GR, Cull N, Hecht O, Ridley H   +7 more
core   +1 more source

Fold or flop: quality assessment of AlphaFold predictions on whole proteomes. [PDF]

Bioinform Adv
Sarti E, Cazals F.
europepmc   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

Advanced Science, EarlyView.
MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo, Qianqian Zhang, Chenhao Wang, Zhiheng Yi, Alex Jinpeng Wang, Jing Tang, Min Li   +6 more
wiley   +1 more source

Conformational dynamics of fuzzy interfaces in disordered protein complexes: mapping key residues and binding modes beyond NMR models. [PDF]

Front Bioinform
Fernández ML, Bastien MC, Tavolaro FG, Marino-Buslje C.   +3 more
europepmc   +1 more source

A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle

Advanced Science, EarlyView.
This study identified a mitochondrial micropeptide encoded by a non‐canonical open reading frame (alt‐ORF) within the CTSB gene. This micropeptide named APPM (ATP production‐promoting micropeptide) is a novel component of the OGDHc complex in the TCA cycle. APPM localizes to the inner mitochondrial membrane and directly binds to OGDH, the E1 subunit of
Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu   +9 more
wiley   +1 more source

Conformational reprogramming of c-Myc <i>via</i> intracellular cyclisation. [PDF]

RSC Chem Biol
Johnson RA, Mason JM.
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Intrinsically disordered protein.

Journal of Molecular Graphics and Modelling, 2001
A. Dunker, J. Lawson, Celeste J. Brown, Ryan M. Williams, P. Romero, Jeong S. Oh, C. Oldfield, A. Campen, C. Ratliff, K. Hipps, J. Ausió, M. Nissen, R. Reeves, C. Kang, C. Kissinger, R. Bailey, M. Griswold, Wah Chiu, E. Garner, Z. Obradovic   +19 more
semanticscholar   +1 more source

Intrinsically disordered regions in the NLRP family of receptors act as regulatory hubs for inflammasome condensation and activation. [PDF]

Front Immunol
Nava-Ramírez TB, Cuevas-Velazquez CL, Covarrubias AA, Rudiño-Piñera E, Pérez-Martínez L, Pedraza-Alva G.   +5 more
europepmc   +1 more source