Results 91 to 100 of about 66,315 (318)

Complex microparticle architectures from stimuli-responsive intrinsically disordered proteins

open access: yesNature Communications, 2020
The production of microparticles with complex geometries for biotechnological use historically requires sophisticated fabrication techniques. Here, the authors create complex particle geometries by exploiting the metastable region of the phase diagram of
Stefan Roberts   +7 more
doaj   +1 more source

Intrinsic disorder in protein interactions: insights from a comprehensive structural analysis. [PDF]

open access: yesPLoS Computational Biology, 2009
We perform a large-scale study of intrinsically disordered regions in proteins and protein complexes using a non-redundant set of hundreds of different protein complexes.
Jessica H Fong   +5 more
doaj   +1 more source

Understanding Viral Transmission Behavior via Protein Intrinsic Disorder Prediction: Coronaviruses [PDF]

open access: yes, 2012
Besides being a common threat to farm animals and poultry, coronavirus (CoV) was responsible for the human severe acute respiratory syndrome (SARS) epidemic in 2002-4. However, many aspects of CoV behavior, including modes of its transmission, are yet to
Dunker, A. Keith   +2 more
core   +3 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Phosphorylation of Intrinsically Disordered Regions in Remorin Proteins

open access: yesFrontiers in Plant Science, 2012
Plant-specific remorin proteins reside in subdomains of plasma membranes, originally termed membrane rafts. They probably facilitate cellular signal transduction by direct interaction with signalling proteins such as receptor-like kinases (RLKs) and may ...
Macarena eMarín, Thomas eOtt
doaj   +1 more source

Testing the transferability of a coarse-grained model to intrinsically disordered proteins [PDF]

open access: yes, 2015
The intermediate-resolution coarse-grained protein model PLUM [T. Bereau and M. Deserno, J. Chem. Phys., 2009, 130, 235106] is used to simulate small systems of intrinsically disordered proteins involved in biomineralisation.
Allen, M. P.   +4 more
core   +2 more sources

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen   +6 more
wiley   +1 more source

The Acidic Domains of the Toc159 Chloroplast Preprotein Receptor Family are Instrinsically Disordered Protein Domains [PDF]

open access: yes, 2009
Background: The Toc159 family of proteins serve as receptors for chloroplast-destined preproteins. They directly bind to transit peptides, and exhibit preprotein substrate selectivity conferred by an unknown mechanism.
Jelokhani-Niaraki, Masoud   +2 more
core   +1 more source

Letter to the Editor: a response to Horne and Lucey (2017) [PDF]

open access: yes, 2017
No abstract ...
Carver, John A.   +3 more
core   +1 more source

Intrinsically Disordered Proteins: Gatekeepers of the Nuclear Pore Complex [PDF]

open access: yesBiophysical Journal, 2016
The transport of molecules between the nucleus and the cytoplasm is facilitated by highly-selective nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPCs provide bidirectional pathways for passive and active (facilitated) transport. Active transport is facilitated by the binding of cargo to chaperons (i.e., transport factors or ‘kaps’
Ghavami, Ali   +3 more
openaire   +2 more sources

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