Electrostatic Forces Mediate Fast Association of Calmodulin and the Intrinsically Disordered Regulatory Domain of Calcineurin [PDF]
arXiv, 2016 Intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) govern a daunting number of physiological processes. For such proteins, molecular mechanisms governing their interactions with proteins involved in signal transduction pathways remain unclear.
arxiv
Albumin Corona Overturns Long‐Acting Behaviors of Myristic Acid‐Conjugated Quetiapine Nanosuspension
Advanced Healthcare Materials, EarlyView.Albumin corona alters surface properties and enhances colloidal stability by overturning pH responsiveness and nano‐aggregation behaviors of long‐acting myristic acid‐conjugated quetiapine nanosuspensions (QMN), resulting in accelerated in vitro and in vivo drug release.
Hy Dinh Nguyen +2 more
wiley +1 more source
Relation between single-molecule properties and phase behavior of intrinsically disordered proteins
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Some proteins can undergo phase separation in vivo to form membraneless organelles with distinct physiological functions. In many cases, the driving force is believed to be the intrinsically disordered domains that lack regular structural ...
G. Dignon +4 more
semanticscholar +1 more source
Making Sense of Intrinsically Disordered Proteins [PDF]
Biophysical Journal, 2016 Proteins form the molecular scaffolding of life and are essential to catalyzing the chemical reactions that sustain living systems. These characteristics have led us to think that proteins function only when folded into the right structure. The central dogma of molecular biology states that genetic information encoded in the DNA sequence is transcribed
openaire +3 more sources
A Bio‐Inspired Perspective on Materials Sustainability
Advanced Materials, EarlyView.This perspective discusses natural materials as inspiration for sustainable engineering designs and the processing of materials. First, circularity, longevity, parsimony, and activity are presented as essential material paradigms. The perspective then uses many examples of natural and technical materials to introduce principles such as oligo ...
Wolfgang Wagermaier +2 more
wiley +1 more source
The standard coil or globule phases cannot describe the denatured state of structured proteins and intrinsically disordered proteins [PDF]
arXivThe concepts of globule and random coil were developed to describe the phases of homopolymers and then used to characterize the denatured state of structured cytosolic proteins and intrinsically disordered proteins. Using multi-scale molecular dynamics simulations, we were able to explore the conformational space of the disordered conformations of both
arxiv
Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins [PDF]
, 2006 Christy L. Haynes
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Supramolecular Chemistry in Metal–Organic Framework Materials
Advanced Materials, EarlyView.This review highlights synergies between reticular chemistry and supramolecular chemistry. The role of supramolecular interactions in determining framework…guest interactions and attempts to understand dynamic behavior in metal–organic frameworks (MOFs), particularly emphasizing the development of crystal sponges, studying reactions in frameworks and ...
Eugenia Miguel‐Casañ +3 more
wiley +1 more source
Intrinsically disordered proteins studied by NMR spectroscopy
Journal of Magnetic Resonance OpenIntrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of complex multi-domain proteins are now identified as a trend topic by the scientific community.
Marco Schiavina +7 more
doaj
Spritz: a server for the prediction of intrinsically disordered regions in protein sequences using kernel machines [PDF]
, 2006 Alessandro Vullo +3 more
openalex +1 more source