Results 261 to 270 of about 448,472 (368)

Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase

Advanced Science, EarlyView.
Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo, Jiechun Lin, Qiwen Ren, Hao Sun, Yanhua Wu, Haofei Ge, Xiaolan Wu, Lihui Lin, Lining Liang, Changpeng Li, He Liu, Yuangbang Mai, Shilong Chu, Jiadong Liu, Jing Liu, Jiekai Chen, Duanqing Pei, Hui Zheng   +17 more
wiley   +1 more source

Deeper Insight of the Conformational Ensemble of Intrinsically Disordered Proteins. [PDF]

J Chem Inf Model
Svensson O, Bakker MJ, Skepö M.
europepmc   +1 more source

DichroIDP: a method for analyses of intrinsically disordered proteins using circular dichroism spectroscopy. [PDF]

Commun Biol, 2023
Miles AJ, Drew ED, Wallace BA.
europepmc   +1 more source

In Vivo Reprogramming of Tissue‐Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering

Advanced Science, EarlyView.
Inspired by exercise‐induced metabolic rewiring and EV secretion, this study shows that in vivo metabolic engineering strategy can reprogram EV secretion pattern and simultaneously attenuate multiple tissue injury in CKD status, highlighting that it is a potential strategy for treating diverse chronic diseases.
Meng Zhao, Shuyun Liu, Yizhuo Wang, Peng Lou, Ke Lv, Tian Wu, Lan Li, Qianyi Wu, Jiaying Zhu, Yanrong Lu, Meihua Wan, Jingping Liu   +11 more
wiley   +1 more source

Beyond monopole electrostatics in regulating conformations of intrinsically disordered proteins. [PDF]

PNAS Nexus
Phillips M, Muthukumar M, Ghosh K.
europepmc   +1 more source

Interpreting Transient Interactions of Intrinsically Disordered Proteins. [PDF]

J Phys Chem B, 2023
Wohl S, Zheng W.
europepmc   +1 more source

2SB1420 Regulatory mechanism of actin capping protein by an intrinsically disordered peptide CARMIL(2SB Intrinsically Disordered Proteins:Structure,Property and Function,The 48th Annual Meeting of the Biophysical Society of Japan)

, 2010
Shuichi Takeda, Shiho Minakata, Ryotaro Koike, K. Kawahata, Akihiro Narita, Masashi Kitazawa, Motonori Ota, Tohru Yamakuni, Yuichiro Maéda, Yasushi Nitanai   +9 more
openalex   +2 more sources

Gentle Label‐Free Nonlinear Optical Imaging Relaxes Linear‐Absorption‐Mediated Triplet

Advanced Science, EarlyView.
The phototoxicity in nonlinear optical microscopy arises mainly from linear absorption of intrinsic biomolecules rather than nonlinear absorption. This mechanism is supported by a reproducible phototoxicity assay based on widely available chicken breast.
Geng Wang, Lianhuang Li, Janet E. Sorrells, Jianxin Chen, Haohua Tu   +4 more
wiley   +1 more source

IDP-Bert: Predicting Properties of Intrinsically Disordered Proteins Using Large Language Models. [PDF]

J Phys Chem B
Mollaei P, Sadasivam D, Guntuboina C, Barati Farimani A.   +3 more
europepmc   +1 more source

Utilization of protein intrinsic disorder knowledge in structural proteomics [PDF]

, 2012
Christopher J. Oldfield, Bin Xue, Ya-Yue J. Van, Eldon L. Ulrich, John L. Markley, A. Keith Dunker, Vladimir N. Uversky   +6 more
openalex   +1 more source