Results 31 to 40 of about 448,472 (368)

Accurate model of liquid–liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Cells may compartmentalize proteins via a demixing process known as liquid–liquid phase separation (LLPS), which is often driven by intrinsically disordered proteins (IDPs) and regions.
Giulio Tesei, Thea K. Schulze, R. Crehuet, K. Lindorff-Larsen   +3 more
semanticscholar   +1 more source

Investigating Intrinsically Disordered Proteins With Brownian Dynamics

Frontiers in Molecular Biosciences, 2022
Intrinsically disordered proteins (IDPs) have recently become systems of great interest due to their involvement in modulating many biological processes and their aggregation being implicated in many diseases.
Surl-Hee Ahn, Gary A. Huber, Gary A. Huber, J. Andrew McCammon, J. Andrew McCammon   +4 more
doaj   +1 more source

How phosphorylation impacts intrinsically disordered proteins and their function

Essays in Biochemistry, 2022
Phosphorylation is the most common post-translational modification (PTM) in eukaryotes, occurring particularly frequently in intrinsically disordered proteins (IDPs). These proteins are highly flexible and dynamic by nature.
E. Newcombe, Elise Delaforge, R. Hartmann-Petersen, K. Skriver, B. Kragelund   +4 more
semanticscholar   +1 more source

Adenoviral E1A Exploits Flexibility and Disorder to Target Cellular Proteins

Biomolecules, 2020
Direct interaction between intrinsically disordered proteins (IDPs) is often difficult to characterize hampering the elucidation of their binding mechanism.
Maria Grazia Murrali, Isabella C. Felli, Roberta Pierattelli   +2 more
doaj   +1 more source

Recent Force Field Strategies for Intrinsically Disordered Proteins

Journal of Chemical Information and Modeling, 2021
Intrinsically disordered proteins (IDPs) are widely distributed across eukaryotic cells, playing important roles in molecular recognition, molecular assembly, post-translational modification, and other biological processes.
Junxi Mu, Hao Liu, Jian Zhang, R. Luo, Haifeng Chen   +4 more
semanticscholar   +1 more source

An intrinsically disordered proteins community for ELIXIR [PDF]

F1000Research, 2019
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELIXIR framework.
Davey, Norman E., Babu, M. Madan, Blackledge, Martin, Bridge, Alan, Capella-Gutierrez, Salvador, Dosztanyi, Zsuzsanna, Drysdale, Rachel, Edwards, Richard J., Elofsson, Arne, Felli, Isabella C., Gibson, Toby J., Gutmanas, Aleksandras, Hancock, John M., Harrow, Jen, Higgins, Desmond, Jeffries, Cy M., Le Mercier, Philippe, Mészáros, Balint, Necci, Marco, Notredame, Cedric, Orchard, Sandra, Ouzounis, Christos A., Pancsa, Rita, Papaleo, Elena, Pierattelli, Roberta, Piovesan, Damiano, Promponas, Vasilis J., Ruch, Patrick, Rustici, Gabriella, Romero, Pedro, Sarntivijai, Sirarat, Saunders, Gary, Schuler, Benjamin, Sharan, Malvika, Shields, Denis C., Sussman, Joel L., Tedds, Jonathan A., Tompa, Peter, Turewicz, Michael, Vondrasek, Jiri, Vranken, Wim F., Wallace, Bonnie Ann, Wichapong, Kanin, Tosatto, Silvio C. E., Davey, Norman E., Babu, M. Madan, Blackledge, Martin, Bridge, Alan, Capella-Gutierrez, Salvador, Dosztanyi, Zsuzsanna, Drysdale, Rachel, Edwards, Richard J., Elofsson, Arne, Felli, Isabella C., Gibson, Toby J., Gutmanas, Aleksandras, Hancock, John M., Harrow, Jen, Higgins, Desmond, Jeffries, Cy M., Le Mercier, Philippe, Mészáros, Balint, Necci, Marco, Notredame, Cedric, Orchard, Sandra, Ouzounis, Christos A., Pancsa, Rita, Papaleo, Elena, Pierattelli, Roberta, Piovesan, Damiano, Promponas, Vasilis J., Ruch, Patrick, Rustici, Gabriella, Romero, Pedro, Sarntivijai, Sirarat, Saunders, Gary, Schuler, Benjamin, Sharan, Malvika, Shields, Denis C., Sussman, Joel L., Tedds, Jonathan A., Tompa, Peter, Turewicz, Michael, Vondrasek, Jiri, Vranken, Wim F., Wallace, Bonnie Ann, Wichapong, Kanin, Tosatto, Silvio C. E.   +87 more
openaire   +9 more sources

On the roles of intrinsically disordered proteins and regions in cell communication and signaling

Cell Communication and Signaling, 2021
For proteins, the sequence → structure → function paradigm applies primarily to enzymes, transmembrane proteins, and signaling domains. This paradigm is not universal, but rather, in addition to structured proteins, intrinsically disordered proteins and ...
Sarah E. Bondos, A. Dunker, V. Uversky
semanticscholar   +1 more source

NeProc predicts binding segments in intrinsically disordered regions without learning binding region sequences

Biophysics and Physicobiology, 2020
Intrinsically disordered proteins are those proteins with intrinsically disordered regions. One of the unique characteristics of intrinsically disordered proteins is the existence of functional segments in intrinsically dis­ordered regions.
Hiroto Anbo, Hiroki Amagai, Satoshi Fukuchi   +2 more
doaj   +1 more source

Identification of Intrinsically Disordered Proteins and Regions in a Non-Model Insect Species Ostrinia nubilalis (Hbn.)

Biomolecules, 2022
Research in previous decades has shown that intrinsically disordered proteins (IDPs) and regions in proteins (IDRs) are as ubiquitous as highly ordered proteins. Despite this, research on IDPs and IDRs still has many gaps left to fill.
Miloš Avramov, Éva Schád, Ágnes Révész, Lilla Turiák, Iva Uzelac, Ágnes Tantos, László Drahos, Željko D. Popović   +7 more
doaj   +1 more source

Intrinsically Disordered Proteins [PDF]

Cell, 2013
Nothing is solid about proteins. Governing rules and established laws are constantly broken. As an example, the last decade and a half have witnessed the fall of one of the major paradigms in structural biology. Contrarily to the more than a century-old belief that the unique function of a protein is determined by its unique structure, which, in its ...
openaire   +4 more sources