Results 61 to 70 of about 32,287 (136)

Molecular signaling involving intrinsically disordered proteins in prostate cancer

Asian Journal of Andrology, 2016
Investigations on cellular protein interaction networks (PINs) reveal that proteins that constitute hubs in a PIN are notably enriched in Intrinsically Disordered Proteins (IDPs) compared to proteins that constitute edges, highlighting the role of IDPs ...
Anna Russo, Sara La Manna, Ettore Novellino, Anna Maria Malfitano, Daniela Marasco   +4 more
doaj   +1 more source

Evaluation of sequence features from intrinsically disordered regions for the estimation of protein function.

PLoS ONE, 2014
With the exponential increase in the number of sequenced organisms, automated annotation of proteins is becoming increasingly important. Intrinsically disordered regions are known to play a significant role in protein function.
Alok Sharma, Abdollah Dehzangi, James Lyons, Seiya Imoto, Satoru Miyano, Kenta Nakai, Ashwini Patil   +6 more
doaj   +1 more source

The Prediction of Intrinsically Disordered Proteins Based on Feature Selection

Algorithms, 2019
Intrinsically disordered proteins perform a variety of important biological functions, which makes their accurate prediction useful for a wide range of applications.
Hao He, Jiaxiang Zhao, Guiling Sun
doaj   +1 more source

Synergy between intrinsically disordered domains and structured proteins amplifies membrane curvature sensing

Nature Communications, 2018
Many proteins which sense membrane curvature contain intrinsically disordered domains. Here the authors use Monte Carlo simulations combined with experimental approaches and report that disordered domains are potent sensors of membrane curvature.
Wade F. Zeno, Upayan Baul, Wilton T. Snead, Andre C. M. DeGroot, Liping Wang, Eileen M. Lafer, D. Thirumalai, Jeanne C. Stachowiak   +7 more
doaj   +1 more source

Fine structures of intrinsically disordered proteins

The Journal of Chemical Physics
We report simulation studies of 33 single intrinsically disordered proteins (IDPs) using coarse-grained bead-spring models where interactions among different amino acids are introduced through a hydropathy matrix and additional screened Coulomb interaction for the charged amino acid beads. Our simulation studies of two different hydropathy scales (HPS1,
Swarnadeep Seth, Brandon Stine, Aniket Bhattacharya   +2 more
openaire   +3 more sources

Diffusion of intrinsically disordered proteins within protein condensates

Physical Review Research
Many intrinsically disordered proteins (IDPs) may undergo a phase separation to form a biomolecular condensate. Understanding the behavior of individual molecules within condensates is crucial for characterizing their collective physical properties ...
Fuga Watanabe, Takuma Akimoto, Robert B. Best, Kresten Lindorff-Larsen, Ralf Metzler, Eiji Yamamoto   +5 more
doaj   +1 more source

Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders

Frontiers in Aging Neuroscience, 2015
Vladimir N. Uversky, Vladimir N. Uversky, Vladimir N. Uversky, Vladimir N. Uversky   +3 more
doaj   +1 more source

Atomic resolution ensembles of intrinsically disordered proteins with Alphafold. [PDF]

Nat Commun
Schnapka V, Morozova TI, Sen S, Bonomi M.   +3 more
europepmc   +1 more source

DisProt in 2026: enhancing intrinsically disordered proteins accessibility, deposition, and annotation. [PDF]

Nucleic Acids Res
Nugnes MV, Bouhraoua KEA, Zoubiri M, Pancsa R, Fichó E, DisProt Consortium , Tompa P, Piovesan D, Tosatto SCE, Aspromonte MC.   +9 more
europepmc   +1 more source

Determining accurate conformational ensembles of intrinsically disordered proteins at atomic resolution [PDF]

Struct Dyn
Borthakur K, Sisk T, Panei F, Bonomi M, Robustelli P.   +4 more
europepmc   +2 more sources