Networks of interbasin traffic in intrinsically disordered proteins
Physical Review Research, 2020 The equilibrium dynamics of the intrinsically disordered proteins is thought to consist of transitions between many basins in the free energy landscape whereas structured proteins stay in the vicinity of one native basin.
Belisa R. H. de Aquino +3 more
doaj +1 more source
Legal Remedies for “Cloud-Seeding” Activities: Nuisance or Trespass? [PDF]
, 1960 Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of proteins are very common and instrumental for cellular signaling.
Dogan, Jakob +2 more
core +3 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Induced folding in RNA recognition by Arabidopsis thaliana DCL1 [PDF]
, 2015 DCL1 is the ribonuclease that carries out miRNA biogenesis in plants. The enzyme has two tandem double stranded RNA binding domains (dsRBDs) in its C-terminus.
Benoit Matthieu P. M. H. +4 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Intrinsically disordered proteins play diverse roles in cell signaling
Cell Communication and Signaling, 2022 Signaling pathways allow cells to detect and respond to a wide variety of chemical (e.g. Ca2+ or chemokine proteins) and physical stimuli (e.g., sheer stress, light).
Sarah E. Bondos +2 more
doaj +1 more source
The Origin of Discrepancies between Predictions and Annotations in Intrinsically Disordered Proteins
Biomolecules, 2023 Disorder prediction methods that can discriminate between ordered and disordered regions have contributed fundamentally to our understanding of the properties and prevalence of intrinsically disordered proteins (IDPs) in proteomes as well as their ...
Mátyás Pajkos +2 more
doaj +1 more source
Differential dehydration effects on globular proteins and intrinsically disordered proteins during film formation [PDF]
, 2017 Globular proteins composed of different secondary structures and fold types were examined by synchrotron radiation circular dichroism spectroscopy to determine the effects of dehydration on their secondary structures.
Araujo, A.P.U. +3 more
core +1 more source
Intrinsically Disordered Proteins Drive Membrane Curvature [PDF]
Biophysical Journal, 2015 Abstract Assembly of highly curved membrane structures is essential to cellular physiology. The prevailing view has been that proteins with curvature-promoting structural motifs, such as wedge-like amphipathic helices and crescent-shaped BAR domains, are required for bending membranes.
Busch, David J. +5 more
openaire +3 more sources