Results 141 to 150 of about 4,746 (287)
Deep learning tools predict variants in disordered regions with lower sensitivity
BMC GenomicsBackground The recent AI breakthrough of AlphaFold2 has revolutionized 3D protein structural modeling, proving crucial for protein design and variant effects prediction.
Federica Luppino +3 more
doaj +1 more source
Counterion Dependent Side‐Chain Relaxation Stiffens a Chemically Doped Thienothiophene Copolymer
Advanced Functional Materials, EarlyView.Oxidation of a thienothiophene copolymer, p(g3TT‐T2), via different doping strategies and dopant molecules resulted in materials with similar oxidation levels and a high electrical conductivity of ≈100 S cm−1. However, mechanical properties varied significantly, with sub‐glass transition temperatures and elastic moduli spanning from –44°C to –3°C and ...
Mariavittoria Craighero +12 more
wiley +1 more source
Impact of intrinsically disordered regions and functional disorder hotspots in the human kinome
Briefings in BioinformaticsAbstract A ubiquitous and reversible phosphorylation is important for molecular signaling cascades, regulated by the transient interaction of protein kinases. The coupled folding and phosphorylation determining substrate specificity re-calibrates the interactive environment of intrinsically disordered regions (IDRs). There are over 50
Sonet Daniel Thomas +16 more
openaire +2 more sources
Role of Intrinsic Electron Trapping in Negative Charging of Amorphous Alumina
Advanced Functional Materials, EarlyView.Intrinsic electron trapping in amorphous Al2O3 is examined using hybrid‐DFT models spanning a wide density range. Both spontaneous and thermally activated trapping are identified, with pronounced spontaneous localization in dense, partly crystallized structures.
Jack W. Strand +5 more
wiley +1 more source
Nature CommunicationsTranscription factors regulate gene expression by binding specific DNA motifs, yet only a fraction of putative sites is occupied in vivo. Intrinsically disordered regions have emerged as key contributors to promoter selectivity, but the underlying ...
Nir Strugo +5 more
doaj +1 more source
Advanced Functional Materials, EarlyView.ABSTRACT Electronic waste has emerged as a major environmental challenge, driven by the massive consumption and a limited lifetime of modern electronic devices, stimulating the development of sustainable electronics. Here, an all‐biomaterial gelatin‐choline‐citric acid ([Ch][CA]) ionogel is developed as an active binder to realize self‐sintered ...
Lin Guo +10 more
wiley +1 more source
Protein intrinsically disordered regions have a non-random, modular architecture [PDF]
, 2023 Brendan S. McConnell, Matthew W Parker
openalex +1 more source
Advanced Functional Materials, EarlyView.This study demonstrates that memristors can replace conventional 2T–1C driving circuits with simplified 1T–1 m architectures by exploiting resistance switching. With ultra‐low switching voltages (< ±0.2 V) and multi‐level resistance states, the memristors precisely control the current injected into organic light‐emitting diodes (OLEDs).
Dong Hyun Kim +6 more
wiley +1 more source
BMC BiologyIntrinsically disordered proteins (IDPs) and biomolecular condensates are critical for cellular processes and physiological functions. Abnormal biomolecular condensates can cause diseases such as cancer and neurodegenerative disorders.
Caolitao Qin +4 more
doaj +1 more source
Biophysical characteristics of NFkappaB-IkappaBalpha’s Intrinsically Disordered Regions [PDF]
In this study we will present a full biophysical characterization of the NFκB-IκBα tertiary complex with a focus on intrinsically disordered regions.
OLIVA, LUIS
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