Results 41 to 50 of about 167,961,110 (305)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Heat Acclimation Enhances Brain Resilience to Acute Thermal Stress in Clarias fuscus by Modulating Cell Adhesion, Anti-Apoptotic Pathways, and Intracellular Degradation Mechanisms

Animals
Global climate change presents a significant challenge to aquatic ecosystems, with ectothermic fish being particularly sensitive to temperature fluctuations.
Yingyi Guan, Cunyu Duan, Xinyu Xie, Zhuoying Luo, Dayan Zhou, Yulei Zhang, Guangli Li, Yu Liao, Changxu Tian   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The behavioural ecology of the Trinidadian guppy, Poecilia reticulata, as an invasive species [PDF]

, 2011
This thesis focuses on the guppy, Poecilia reticulata, as an invasive species. Its non-native distribution, the biology behind its success and the reasons for its introduction are examined.
Deacon, Amy E.
core   +2 more sources

Ontomorphogenesis of plant of the genus Astragalus L. species in conditions of introduction in the Right-Bank of Forest-Steppe of Ukraine

Інтродукція Рослин, 2016
Purpose – to establish of ontomorphogenesis peculiarities of species of the genus Astragalus L. for the first, second and subsequent years of their life in conditions of introduction into the Right-Bank of Forest-Steppe of Ukraine.
O.P. Bondarchuk, D.B. Rakhmetov
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effects of Chronic Heat Stress on Growth, Apoptosis, Antioxidant Enzymes, Transcriptomic Profiles, and Immune-Related Genes of Hong Kong Catfish (Clarias fuscus)

Animals
Chronic heat stress can have detrimental effects on the survival of fish. This study aimed to investigate the impact of prolonged high temperatures on the growth, antioxidant capacity, apoptosis, and transcriptome analysis of Hong Kong catfish (Clarias ...
Yong Liu, Changxu Tian, Zhihua Yang, Cailin Huang, Kaizhi Jiao, Lei Yang, Cunyu Duan, Zhixin Zhang, Guangli Li   +8 more
doaj   +1 more source

Assessment of the success of the introduction of rare and endangered plant species into the Kryvyi Rih Botanical Garden of the NAS of Ukraine

Інтродукція Рослин, 2018
Objective – to evaluate the results of the introduction success and to determine perspectives of conservation of rare and endangered plant species in the culture in conditions of the Right-Bank of Steppe Dnieper region. Material and methods. Object of
H.N. Sholl
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Integrative QTL Mapping and Transcriptomic Profiling to Identify Growth-Associated QTL and Candidate Genes in Hong Kong Catfish (Clarias fuscus)

Animals
Growth traits are critical economic characteristics in aquaculture. This study aimed to identify the candidate genes associated with the growth of C. fuscus by integrating QTL mapping for growth traits and the RNA-seq analysis of differentially expressed
Yian Zhu, Dayan Zhou, Yijun Shen, Chuanhao Pan, Yu Chen, Yulei Zhang, Binlan Yang, Guangli Li, Huapu Chen, Changxu Tian   +9 more
doaj   +1 more source