Results 61 to 70 of about 12,595 (208)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Productivity of plants of the genus Astragalus L. species in conditions of introduction into Right-Bank of Forest-Steppe of Ukraine

Інтродукція Рослин, 2017
Objective – to study peculiarities of productivity of the seeds and aboveground phytomass of plants of the genus Astragalus L. species depending on species and vegetation conditions of the introduction into Right-Bank of Forest- Steppe of Ukraine ...
O.P. Bondarchuk, D.B. Rakhmetov
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

BOTANICAL GARDEN NAMED AFTER JÓZSEF SZIKURA

Biota. Human. Technology
Objective is to study and analyse the history of the creation of the József Szikura Botanical Garden, the results of its scientific, educational and environmental work. Materials and methods of the study.
Erzsébet Kohut, Anita Szikura, Zoltán Kopor, István Kolozsvári   +3 more
doaj   +1 more source

High-potential energy plants of Miscanthus Anderss. genus introduced in M.M. Gryshko National Botanical Garden of the NAS of Ukraine

Інтродукція Рослин, 2015
Purpose – to determine the most effective alternative sources of biofuels based on an analysis of introducents of genus Miscanthus Anderss., which are grown in M.M.
D.B. Rakhmetov, T.O. Scherbakova, S.О. Rakhmetova   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Prospects of introduction of species from Hypericum L. genus

Інтродукція Рослин, 2000
Comparative introductive research of 73 Hypericum L. species from all 30 sections of the genus, not growing in wild conditions in Ukraine, has been carried out in M.M. Grishko National Botanical Gardens (Kyiv, Ukraine).
E.Y. Makovetskaya
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Environmental management and stewardship practices in Antarctic science and tourism: do they align with environmental concerns?

Polar Research
In the Antarctic Peninsula, tourism and science operations are interconnected and overlap spatially and temporally, sharing practices aimed at reducing and mitigating the human footprint.
Daniela Cajiao, Pablo Tejedo, Bas Amelung, Javier Benayas, Machiel Lamers   +4 more
doaj   +1 more source