Results 91 to 100 of about 292,600 (397)
Proceedings, 2017 Information content of a polymeric macromolecule can be calculated in bits, by multiplying the number of building blocks that encompasses the entire length of the macromolecule with the Shannon’s entropy of each building block, which could be determined ...
Yekbun Adiguzel
doaj +1 more source
Identification of human short introns. [PDF]
PLoS ONE, 2017 Canonical pre-mRNA splicing requires snRNPs and associated splicing factors to excise conserved intronic sequences, with a minimum intron length required for efficient splicing.
Emmanuel L Abebrese +14 more
doaj +1 more source
Bioessays, 2014 A gene's “expression profile” denotes the number of transcripts present relative to all other transcripts. The overall rate of transcript production is determined by transcription and RNA processing rates.
P. Heyn +3 more
semanticscholar +1 more source
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
The Complex Intron Landscape and Massive Intron Invasion in a Picoeukaryote Provides Insights into Intron Evolution [PDF]
Genome Biology and Evolution, 2013 Genes in pieces and spliceosomal introns are a landmark of eukaryotes, with intron invasion usually assumed to have happened early on in evolution. Here, we analyze the intron landscape of Micromonas, a unicellular green alga in the Mamiellophyceae lineage, demonstrating the coexistence of several classes of introns and the occurrence of recent massive
Pierre Rouzé +3 more
openaire +4 more sources
Bacterial group I introns: mobile RNA catalysts
Mobile DNA, 2014 Group I introns are intervening sequences that have invaded tRNA, rRNA and protein coding genes in bacteria and their phages. The ability of group I introns to self-splice from their host transcripts, by acting as ribozymes, potentially renders their ...
G. Hausner, Mohamed Hafez, D. Edgell
semanticscholar +1 more source
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Comparison of Intron-Dependent and Intron-Independent Gene Expression [PDF]
Molecular and Cellular Biology, 1988 Recombinant simian virus 40 viruses carrying rabbit beta-globin cDNA failed to express the beta-globin sequence unless an intron was included in the transcription unit. The addition of either beta-globin IVS1 or IVS2 caused a 400-fold increase in RNA production.
Paul Berg, A R Buchman
openaire +3 more sources
Modeling in yeast how rDNA introns slow growth and increase desiccation tolerance in lichens
G3: Genes, Genomes, Genetics, 2021 We connect ribosome biogenesis to desiccation tolerance in lichens, widespread symbioses between specialized fungi (mycobionts) and unicellular phototrophs.
Daniele Armaleo, Lilly Chiou
doaj +1 more source
The largest reservoir of mitochondrial introns is a relic of an ancestral split gene [PDF]
, 2010 In eukaryotes, introns are located in nuclear and organelle genes from several kingdoms (ref. 1-4). Large introns (0.1 to 5 kbp) are frequent in mitochondrial genomes of plant and fungi (ref.
Cyril Ferandon +5 more
core +1 more source