Results 91 to 100 of about 152,197 (251)
Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response
Advanced Science, EarlyView.This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du +10 more
wiley +1 more source
Advanced Science, EarlyView.CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin +17 more
wiley +1 more source
Group I introns in tRNA genes of Patescibacteria
mSystemsIntrons are generally considered rare in bacteria, yet they are frequently observed in Patescibacteria, which have highly reduced genomes. To systematically explore the diversity, roles, and evolution of introns in Patescibacteria, we first focused on ...
Yuna Nakagawa +3 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song +9 more
wiley +1 more source
Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery
Advanced Science, EarlyView.A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li +9 more
wiley +1 more source
, 2014 Introni su dijelovi DNA, odnosno RNA, koji se izrezuju iz primarnog transkripta i ne kodiraju za polipeptidni lanac. Izrezivanje može biti katalizirano samim intronom ili pak ribonukleoproteinskim kompleksom, a događa se tijekom transkripcije molekule ...
Zanki, Vladimir
core
Lengths of introns containing CLIP tags and relative position of tags within introns.
, 2016 Lengths of introns containing CLIP tags and relative position of tags within introns.
Twishasri Dasgupta (378762) +3 more
core +1 more source
Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges
Advanced Science, EarlyView.Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen +6 more
wiley +1 more source
Densities of introns along the genes.
, 2016 Genes containing at least five introns were selected and divided into five equal intervals; then numbers of introns in each interval were calculated. Different bar colors designate groups of introns (see the inserted legend).
Mikhail S. Gelfand (10782) +1 more
core +1 more source
A mutation in a splicing factor that causes retinitis pigmentosa has a transcriptome-wide effect on mRNA splicing [PDF]
, 2014 Background: Substantial progress has been made in the identification of sequence elements that control mRNA splicing and the genetic variants in these elements that alter mRNA splicing (referred to as splicing quantitative trait loci – sQTLs).
Ramesar, Raj +7 more
core +1 more source