Results 181 to 190 of about 217,998 (332)
Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns. [PDF]
, 1982 Shintaroh Ueda +4 more
openalex +1 more source
Advanced Science, EarlyView.L14‐8, a small molecule derived from the marketed drug ezetimibe, potently inhibits advanced prostate cancer independent of androgen receptor signaling. L14‐8 binds PLK1, triggering its ubiquitin‐mediated degradation. This activates TP53‐dependent transcription of SAT1, inducing ferroptosis and suppressing tumor growth in prostate cancer patient ...
Yu Zhang +8 more
wiley +1 more source
Self-splicing of a group II intron in yeast mitochondria: dependence on 5′ exon sequences. [PDF]
, 1987 Renske M. van der Veen +2 more
openalex +1 more source
EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways
Advanced Science, EarlyView.EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen +12 more
wiley +1 more source
Molecular biology: No introns in insect globin genes [PDF]
, 1984 Athel Cornish‐Bowden
openalex +1 more source
PRC1‐Mediated H2Aub Loop Formation and Function in Arabidopsis
Advanced Science, EarlyView.In the Arabidopsis genome, H2Aub and H3K27me3 marks do not always co‐localize, and some regions are marked exclusively by H2Aub. By using Capture‐Hi‐C, it is found that H2Aub loops are preferentially established between two H2Aub enriched regions.
Lingxiao Luo +8 more
wiley +1 more source
Evidence that introns arose at proto-splice sites. [PDF]
, 1989 N. J. Dibb, Andrew J. Newman
openalex +1 more source
Advanced Science, EarlyView.DSBs are the most critical genomic lesions. Using the ChromInSight framework, It is revealed that 3D chromatin structure, rather than linear distance, shapes cluster‐scene between hub‐Nodes and DSB loci. The “spatial isolation–damage containment” hypothesis is proposed to illustrate how the genome responds to genomic damage and offer a powerful tool ...
Kang Xu +9 more
wiley +1 more source