Results 271 to 280 of about 292,600 (397)

Introns are not garbage

, 2001
A genome is an informatics project, and a budget too. Everybody knows that the personal budget of a family can be written in a few pages whilst the State budget needs many big books. The garbage hypothesis doesn"t explain this obvious fact; Bioinformatics and common sense do. Recibido: 27-3-01. Aceptado: 6-4-01.
openaire   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Pervasive Conservation of Intron Number and Other Genetic Elements Revealed by a Chromosome-level Genome Assembly of the Hyper-polymorphic Nematode Caenorhabditis brenneri. [PDF]

Genome Biol Evol
Teterina AA, Willis JH, Baer CF, Phillips PC.   +3 more
europepmc   +1 more source

Expression of the "split gene" cob in yeast mtDNA. Nuclear mutations specifically block the excision of different introns from its primary transcript.

, 1983
Timothy M. Pillar, B. Franz Lang, Iris Steinberger, Bernd Vogt, F. Kaudewitz   +4 more
openalex   +1 more source

Molecular biology: No introns in insect globin genes [PDF]

, 1984
Athel Cornish‐Bowden
openalex   +1 more source

The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated‐B Cells

Exploration, EarlyView.
Bcas2 recruits DHX15 and SRSF7 to form a protein complex for the splicing of CSR‐related mRNA at the 5' ss and 3' ss, generating two mature mRNA isoforms, which are ultimately translated into CSR‐related proteins. These CSR‐related proteins bind to DNA associated with antibodies, affecting the DSB repair of the relevant DNA after AID induction, thereby
Yu Chen, Siyuan Sun, Chenxu Lu, Yixuan Li, Bing Fang, Xiangfeng Tang, Xuepeng Li, Weiru Yu, Yumei Lei, Longjie Sun, Ming Zhang, Jiazeng Sun, Ping Liu, Yongting Luo, Xingwang Zhao, Jing Zhan, Libing Liu, Rong Liu, Jiaqiang Huang, Ziwei Yi, Yifei Yu, Weihan Xiao, Zheng Ding, Lei Li, Dan Su, Fazheng Ren, Changchang Cao, Ran Wang, Wenbiao Shi, Juan Chen   +29 more
wiley   +1 more source

Accurate, comprehensive database of group I introns and their homing endonucleases. [PDF]

Bioinform Adv
Sellés Vidal L, Noma T, Yokobayashi Y.
europepmc   +1 more source

Identification of a novel latency-specific splice donor signal within the herpes simplex virus type 1 2.0-kilobase latency-associated transcript (LAT): translation inhibition of LAT open reading frames by the intron within the 2.0-kilobase LAT [PDF]

, 1991
J G Spivack, Gary Woods, Nicholas Fraser
openalex   +1 more source

Decoding RNA–Protein Interactions: Methodological Advances and Emerging Challenges

Advanced Genetics, EarlyView.
This review provides a comprehensive comparison of RNA‐ and protein‐centric methodologies for investigating RNA–protein interactions, emphasizing their respective advantages, limitations, and suitable applications. It highlights recent technological innovations, outlines strategic method selection criteria, and addresses key challenges.
Wenkai Yi, Jian Yan
wiley   +1 more source

Identification of human pathways acting on nuclear non-coding RNAs using the Mirror forward genetic approach. [PDF]

Nat Commun
Che R, Panah M, Mirani B, Knowles K, Ostapovich A, Majumdar D, Chen X, DeSimone J, White W, Noonan M, Luo H, Alexandrov A.   +11 more
europepmc   +1 more source