Results 301 to 310 of about 304,363 (385)

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source

Expansion of the functional genomics GRACE library reveals genes relevant for temperature-dependent fitness in Candida albicans. [PDF]

PLoS Biol
Fu C, Xiong EH, Kupczok L, Archambault LS, Wang TRW, Holleran C, Carruthers-Lay D, Zhuang TX, Marcoccia S, Zhang H, Chen K, Anderson D, Yiu B, Liu Z, Herzel L, Robbins N, Cowen LE.   +16 more
europepmc   +1 more source

Uncovering the role of genetic polymorphisms in cervical insufficiency

International Journal of Gynecology &Obstetrics, EarlyView.
Pathways and genes implicated in CI pathogenesis. Abstract Cervical insufficiency (CI) is characterized by spontaneous dilation of the cervix in the absence of painful uterine contractions in the mid‐trimester, leading to premature delivery. It is responsible for up to 20% of second trimester pregnancy losses, mostly <24 weeks.
Kallirhoe Kalinderi, Michail Kalinderis, Maria Chatzidimitriou, Liana Fidani   +3 more
wiley   +1 more source

Characterization of the five Amanita complete mitochondrial genome and the phylogenetic relationship with other Amanita fungi. [PDF]

BMC Genomics
Wang X, Xu G, Tao J, Wang G, Guo Z, Luo H, Li G, Liu H, Deng C, Wu Y.   +9 more
europepmc   +1 more source

Genome‐wide CRISPR screen reveals an uncharacterized spliceosome regulator as new candidate immunotherapy target

iMeta, EarlyView.
This study identifies the uncharacterized gene C9ORF50 as a novel regulator of immune evasion. Functioning as an intrinsically disordered protein, C9ORF50 drives liquid‐liquid phase separation to facilitate spliceosome assembly and maintain RNA splicing fidelity.
Tong Shao, Chuanyang Liu, Jingyu Kuang, Sisi Xie, Ying Qu, Yingying Li, Lulu Zhang, Fangzhou Liu, Yanhua Qi, Tao Hou, Ming Li, Sujuan Zhang, Yu Liu, Zhixiang Yuan, Jiali Liu, Yanming Hu, Jingyang Wang, Chenghu Song, Shaowei Zhang, Lingyun Zhu, Jianzhong Shao, Aifu Lin, Wenjun Mao, Guangchuan Wang, Lvyun Zhu   +24 more
wiley   +1 more source

Characterization of <i>Ganoderma pseudoferreum</i> mitogenome revealed a remarkable evolution in genome size and composition of protein-coding genes. [PDF]

Front Plant Sci
Lu J, Qin C, Huo S, Wang H, Norvienyeku J, Miao W, Liu W.   +6 more
europepmc   +1 more source

A Novel Frameshift Variant c.1023_1029del (p.Asp342ArgfsTer54) Leading to Extended Incorrect Protein C Termini in HOMER2 Causing Autosomal Dominant Nonsyndromic Hearing Loss

Journal of Clinical Laboratory Analysis, EarlyView.
We identified a novel c.1023_1029del (p.Asp342ArgfsTer54) frameshift variant in the HOMER2 gene that causes ADNSHL in a Chinese family with progressive, post‐lingual sensorineural hearing loss. The c.1023_1029del variant deletes 7 nucleotides, leading to an extended incorrect protein C terminus and marks the sixth pathogenic (or likely pathogenic ...
Li‐Ting Peng, Wei‐Qian Wang, Sha‐Sha Huang, Min Liu, Su‐Yan Yang, Dong‐Yang Kang, Xiang Wang, Xue Gao, Yong‐Yi Yuan, Jin‐Cao Xu   +9 more
wiley   +1 more source

Molecular basis of backsplicing regulation and its application to manipulate circRNA levels. [PDF]

RNA Biol
Wang Y, Dzakah EE, Wang X.
europepmc   +1 more source

Characterization of the polymorphism detected for the granule‐bound starch synthase (WX gene) in wild einkorn wheat

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The WX gene encodes the granule‐bound starch synthase I or waxy protein, which is the sole enzyme responsible for amylose synthesis in wheat seeds. Wild einkorn wheat (Triticum monococcum L. ssp. aegilopoides Link em. Thell.) could be an important source of variation for this gene. RESULTS This study assessed the WX gene variability
Juan B. Alvarez, Laura Castellano, Carlos Guzmán   +2 more
wiley   +1 more source

Impact of E‐Beam Sterilization on Bioglass Composite Shape Memory Scaffolds

Macromolecular Materials and Engineering, EarlyView.
Electron beam (E‐beam) sterilization is an attractive alternative to conventional methods (e.g., ethylene oxide) to sterilize medical devices such as scaffolds used to heal bone defects. Herein, the impact of E‐beam sterilization on the properties of “self‐fitting” shape memory polymer (SMP) scaffolds prepared from resorbable polyesters and a bioglass ...
Brandon M. Nitschke, MaryGrace N. Wahby, Melissa A. Grunlan   +2 more
wiley   +1 more source