Results 301 to 310 of about 292,600 (397)

TNF signature in advanced melanoma patients treated with immune checkpoint inhibitors: Results from the MELANFα clinical study

International Journal of Cancer, EarlyView.
What's New? Tumor necrosis factor (TNF) can promote tumor resistance to immune checkpoint inhibitors (ICIs), which are now the standard treatment for advanced melanoma patients. Here, in an advanced melanoma patient cohort, TNF was investigated for a possible predictive relationship with ICI response. Assessments show that after 12 weeks of ICI therapy,
Mathieu Virazels, Amélie Lusque, Stéphanie Brayer, Matthieu Genais, Carine Dufau, Jean Milhès, Thomas Filleron, Cécile Pagès, Vincent Sibaud, Laurent Mortier, Olivier Dereure, Maha Ayyoub, Amandine Fabre, Nathalie Andrieu‐Abadie, Vera Pancaldi, Céline Colacios, Nicolas Meyer, Bruno Ségui, Anne Montfort   +18 more
wiley   +1 more source

PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites. [PDF]

Nucleic Acids Res
Yadav M, AlQazzaz MA, Ciamponi FE, Ho JC, Maron MI, Sababi AM, MacLeod G, Ahmadi M, Bullivant G, Tano V, Langley SR, Sánchez-Osuna M, Sachamitr P, Kushida M, Bardile CF, Pouladi MA, Kurtz R, Richards L, Pugh T, Tyers M, Angers S, Dirks PB, Bader GD, Truant R, Massirer KB, Barsyte-Lovejoy D, Shechter D, Harding RJ, Arrowsmith CH, Prinos P.   +29 more
europepmc   +1 more source

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source

Co-transcriptional splicing is delayed in the highly expressed thyroglobulin gene.

J Cell Sci
Ullrich S, Nadelson I, Krebs S, Blum H, Leonhardt H, Solovei I.   +5 more
europepmc   +1 more source

A differentiated β-globin gene replacement strategy uses heterologous introns to restore physiological expression. [PDF]

Mol Ther
Wallace KA, Gerstenberg TL, Ennis CL, Perez-Bermejo JA, Partridge JR, Bandoro C, Matern WM, Andreoletti G, Krassovsky K, Kabir S, Lalisan CD, Churi AR, Chew GM, Corbo L, Vincelette JE, Klasson TD, Silva BJ, Strukov YG, Quejarro BJ, Hill KA, Treusch S, Grogan JL, Dever DP, Porteus MH, Wienert B.   +24 more
europepmc   +1 more source

An E-box element localized in the first intron mediates regulation of the prothymosin alpha gene by c-myc. [PDF]

, 1994
Stefan Gaubatz, Albrecht Meichle, Martin Eilers   +2 more
openalex   +1 more source

Haplotype‐resolved genome and pan‐genome graphs reveal the impacts of structural variation on functional genome and feather colors in chickens

iMetaOmics, EarlyView.
This study built a Wenchang chicken haplotype genome and integrated it with 29 others to create a chicken pangenome atlas. Analysis of 354 chickens revealed 185,205 structural variations (SVs), with one‐third derived from homology‐based and transposable elements.
Lihong Gu, Chen Peng, Anhong Chen, Kaiyu Chen, Xinli Zheng, Dongyou Yu, Zhengguang Wang, Lingzhao Fang, George E. Liu, Pengju Zhao   +9 more
wiley   +1 more source

Expansion of the tmRNA sequence database and new tools for search and visualization. [PDF]

NAR Genom Bioinform
Nawrocki EP, Petrov AI, Williams KP.
europepmc   +1 more source

Splicing of group II introns in mRNAs coding for cytochrome b₆ and subunit IV in the liverwort Marchantia polymorpha chloroplast genome Exon specifying a region coding for two genes with the spacer region

, 1987
Hideya Fukuzawa, Tadashi Yoshida, Takayuki Kohchi, Takeshi Okumura, Yasuji Sawano, Kanji Ohyama   +5 more
openalex   +1 more source

SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing. [PDF]

Elife
Govindan A, Conrad NK.
europepmc   +1 more source