Results 41 to 50 of about 180,067 (246)

A 5-year follow-up case of multiple intrusive luxative injuries

open access: yesDental Hypotheses, 2012
Introduction: Traumatic intrusive luxation is one of the most severe forms of dental injuries, usually affecting the maxillary incisors. The consequence of such an occurrence is a high risk of healing complications such as pulp necrosis, external ...
Seema Thakur, Narbir S Thakur
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Machine Learning for Intrusion Detection: Modeling the Distribution Shift [PDF]

open access: yes, 2010
This paper addresses two important issue that arise in formulating and solving computer intrusion detection as a machine learning problem, a topic that has attracted considerable attention in recent years including a community wide competition using a ...
Saunders, Craig   +5 more
core   +2 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Periodontal and Periapical Responses to Mandibular Incisor Intrusion: Conventional Method Vs. Bone Anchorage

open access: yesTurkish Journal of Orthodontics, 2011
Aim:To investigate the gingival and periapical side effects of mandibular incisor intrusion using mini-implants and to compare these with those of a conventional mandibular incisor intrusion mechanic, the utility arch.Subjects and Methods:26 deep bite ...
Esen Aydoğdu   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Management of traumatically intruded permanent incisors

open access: yesJournal of Indian Society of Pedodontics and Preventive Dentistry, 2007
Intrusive luxation of permanent teeth has great psychologic impact on both parents and children and presents clinical challenge for the dentist, all the more due to severe complications it is difficult to manage this group of dental injuries.
Shivayogi M, Anand L, Dayanand D
doaj  

Intrusion of Dacron Sutures and A Recurrent Vitreous Hemorrhage: Rare Complication of Scleral Buckle

open access: yesDelhi Journal of Ophthalmology, 2020
We present a case of intrusion of a Dacron suture 8 years after scleral buckling surgery. Though rare, scleral buckle has to be removed if it is associated with complications like intrusion or extrusion, infection, or anterior segment ischemia.
Jignesh Manshibhai Gala, Raja Narayanan
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

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