Results 101 to 110 of about 2,861,414 (289)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Intrusion Detection System based on Ant [PDF]
, 2017 Challenge of designing and building of the current Network Intrusion Detection System not only improves the ability for discriminating the improper internet behaviors but also considers the plenty of computer resources which will be cost during the ...
H.Fathima
core
Efficient intrusion detection scheme based on SVM
, 2013 The network intrusion detection problem is the focus of current academic research. In this paper, we propose to use Support Vector Machine (SVM) model to identify and detect the network intrusion problem, and simultaneously introduce a new optimization ...
Zhou, Guangping, Shrestha, Anup
core +1 more source
Distributed Hierarchical IDS For MANET Over AODV+. [PDF]
, 2007 In this paper, we introduce background knowledge of wireless ad hoc networking mobile ad hoc network (MANET) as well as intrusion detection system (IDS) and mobile agents.
Samsudin, Azman, Pahlevanzadeh, Bahareh
core +1 more source
Alexandria Engineering JournalThe swift proliferation of IoT devices has brought about a multitude of complex cyberattacks that breach network security and compromise user privacy.
Hui Chen +5 more
doaj +1 more source