Results 121 to 130 of about 236,957 (268)

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

Surgical management of recurrent oesophageal obstruction in a yearling Saddlebred filly

Equine Veterinary Education, EarlyView.
Summary This case report describes the diagnostic approach and surgical management of a yearling Saddlebred filly with recurrent oesophageal obstruction, likely caused by an acquired extraluminal oesophageal stricture. The filly initially presented with repeated episodes of oesophageal obstruction, which were resolved with sedation and nasogastric ...
K. M. Andrews, J. Melcher, J. F. Peroni, M. Perlini, E. M. Beasley   +4 more
wiley   +1 more source

Management of COVID-19-related post-intubation tracheal stenosis. [PDF]

Front Surg, 2023
Conforti S, Licchetta G, Reda M, Astaneh A, Pogliani L, Fieschi S, Rinaldo A, Torre M.   +7 more
europepmc   +1 more source

Hamman's crunch—A pathognomonic sign of pneumomediastinum

Equine Veterinary Education, EarlyView.
Summary Pneumomediastinum, particularly spontaneous pneumomediastinum, is uncommon and presents a diagnostic challenge. In human medicine, auscultation of Hamman's crunch, a crepitant, crunching noise, audible over the cardiac region in synchrony with the heartbeat, is considered pathognomonic for pneumomediastinum.
S. McCullagh, C. R. Daniel, J. A. Keen, N. J. Parkinson, B. C. McGorum   +4 more
wiley   +1 more source

Complex Post-intubation Tracheal Stenosis in Covid-19 Patients. [PDF]

Indian J Surg, 2022
Beyoglu MA, Sahin MF, Turkkan S, Yazicioglu A, Yekeler E.   +4 more
europepmc   +1 more source

A multi‐centre retrospective review of the bronchoscopic management of upper tracheal stenosis: An Australian perspective

Internal Medicine Journal, EarlyView.
Abstract Background Upper tracheal stenosis (UTS) is a rare process with multiple causes and variable approaches to treatment. Australian data on management patterns are lacking and patient resources reflecting local practices are scarce. Aims To describe the management strategies of UTS over 12 years among three teaching hospitals in New South Wales ...
Nathan Harb, David K. E. Chan, Eugenie Dale, Tsu‐Hui (Hubert) Low, Tajalli Saghaie, Alvin J. Ing, Jonathan Williamson   +6 more
wiley   +1 more source

Post-intubation tracheal lacerations: Risk-stratification and treatment protocol according to morphological classification. [PDF]

Front Surg, 2022
Cardillo G, Ricciardi S, Forcione AR, Carbone L, Carleo F, Di Martino M, Jaus MO, Perdichizzi S, Scarci M, Ricci A, Dello Iacono R, Lucantoni G, Galluccio G.   +12 more
europepmc   +1 more source

Effect of vertical distance between the heart base and the cuff on arterial blood pressure measurements using PetMAP in anaesthetised dogs

Journal of Small Animal Practice, EarlyView.
Objectives To evaluate how variations in limb positioning, when compared with standard position at the heart base, affect oscillometric arterial blood pressure measurements in 22 anaesthetised healthy dogs. Materials and Methods The thoracic vertical depth was measured in each dog from the caudal angle of the scapula to the body of the sternum caudal ...
R. McConomy, H. Pinnok, C. Adami
wiley   +1 more source

Case series of endoscopic treatment of post-intubation tracheal stenosis. [PDF]

Respir Med Case Rep, 2022
Salloum S, Tawk M, Nehme R, Siblani D, Haddad Y.   +4 more
europepmc   +1 more source

Perioperative Management for Patients With Spinal Muscular Atrophy Undergoing Scoliosis Surgery: A Single‐Center Retrospective Study

Orthopaedic Surgery, EarlyView.
This largest Asian case series confirms that posterior spinal fusion for SMA scoliosis is safe and effective despite severe deformity and markedly impaired pulmonary function. Meticulous multidisciplinary care, including advanced airway planning, hemodynamic support, blood management, and proactive electrolyte correction, is critical to optimizing ...
Ai Hu, Xiuhua Zhang, Lulu Ma, Haisong Lu, Yulei Dong, Weiyun Chen, Yuguang Huang, Jianxiong Shen   +7 more
wiley   +1 more source