Results 41 to 50 of about 47,178 (343)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Childhood intussusception: 17-year experience at a tertiary referral centre in Hong Kong [PDF]

, 2015
published_or_final_versio
Chan, IHY, Chung, PHY, Lam, WWM, Lan, LCL, Tam, PKH, Wong, CWY, Wong, KKY   +6 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Is it necessary to screen for celiac disease in all children with intussusception?

Trends in Pediatrics
Objective: While there is a close relationship between celiac disease (CD) and intussusception, it is not yet clear whether the detection of intussusception in children requires physicians to always screen for CD. In our study, we aimed to determine the
Melike Arslan, Gökhan Berktuğ Bahadır, Mehmet Bahadır Çalışkan, Coşkun Fırat Özkeçeci, Edibe Gözde Başaran, Sevim Ecem Ünlü Ballı, Hüseyin Emre Atasever, Necati Balamtekin   +7 more
doaj   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Intussusception in Five Months Old Infant, A Rare Cause Colocolica without Pathologic Lead Point: A Case Report

Archives of Pediatric Gastroenterology, Hepatology, and Nutrition, 2022
Intussusception is a common cause in gastrointestinal obstruction and one of condition in which early treatment is critical. Given the risk of acute bowel ischemia, intussusception represents an abdominal emergency in the pediatric population.
Yusri Dianne, Mutiara Annisa Amadea, Yorva Sayoeti   +2 more
doaj   +1 more source

The importance of recent infection with Mycobacterium tuberculosis in an area with high HIV prevalence: a long-term molecular epidemiological study in Northern Malawi.

, 2005
BACKGROUND: The proportion of cases of tuberculosis due to recent infection can be estimated in long-term population-based studies using molecular techniques.
Crampin, Amelia C, Drobniewski, Francis, Fine, Paul EM, Glynn, Judith R, Mwaungulu, Frank D, Ndlovu, Richard, Ngwira, Bagrey M, Traore, Hamidou, Yates, Malcolm D   +8 more
core   +1 more source

Small bowel intussusception from renal cell carcinoma metastasis : a case report and review of the literature [PDF]

, 2016
Background: Renal cell carcinoma is the most frequent malignant neoplasia of the kidney accounting for 90 % of all renal solid tumors. Metastases from renal cell carcinoma are rarely located in the small bowel and generally their clinical presentation ...
Bellio, Gabriele, Bortul, Marina, Casagranda, Biagio, Cipolat Mis, Tommaso, Dattola, Roberto, Kaso, Gladiola   +5 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source