Results 21 to 30 of about 4,377,369 (241)

inv(16)(p13q22) - t(16;16)(p13;q22) - del(16)(q22) [PDF]

, 1999
Review on inv(16)(p13q22) - t(16;16)(p13;q22) - del(16)(q22), with data on clinics, and the genes ...
Huret, JL, JL Huret
core   +1 more source

inv(16)(p13q22) in treatment related leukemia [PDF]

, 2004
Review on inv(16)(p13q22) in treatment related leukemia, with data on clinics, and the genes ...
Huret, JL, JL Huret
core   +1 more source

M4 acute myeloid leukemia: the role of eosinophilia and cytogenetics in treatment response and survival. The GIMEMA experience

Haematologica, 2008
Background Myelomonocytic acute myeloid leukemia (M4-AML) is frequently associated with the cytogenetic marker inv(16) and/or the presence of eosinophilia. The aim of this study was to analyze the incidence and prognostic role of these factors in a large
Alessandro Pulsoni, Simona Iacobelli, Massimo Bernardi, Marco Borgia, Andrea Camera, Nicola Cantore, Francesco Di Raimondo, Paola Fazi, Felicetto Ferrara, Franco Leoni, Vincenzo Liso, Marco Mancini, Filippo Marmont, Angela Matturro, Luca Maurillo, Lorella Melillo, Giovanna Meloni, Salvo Mirto, Giorgina Specchia, Caterina Giovanna Valentini, Adriano Venditti, Giuseppe Leone, Robin Foà, Franco Mandelli, Livio Pagano   +24 more
doaj   +1 more source

De Novo Acute Myeloid Leukemia with Combined CBFB-MYH11 and BCR-ABL1 Gene Rearrangements: A Case Report and Review of Literature

Case Reports in Hematology, 2020
Acute myeloid leukemia (AML) with inv(16)(p13.1q22) resulting in CBFB-MYH11 fusion is associated with a favorable prognosis. The presence of a KIT mutation modifies it to an intermediate prognosis.
Venkata Rakesh Sethapati, Ra’ed Jabr, Leyla Shune, Wissam El Atrouni, Patrick R. Gonzales, Wei Cui, Shivani Golem   +6 more
doaj   +1 more source

Coexistence of recurrent chromosomal abnormalities and the Philadelphia chromosome in acute and chronic myeloid leukemias: report of five cases and review of literature

Molecular Cytogenetics, 2020
Progression of chronic myelogenous leukemia (CML) is frequently accompanied by cytogenetic evolution. Additional genetic abnormalities are seen in 10–20% of CML cases at the time of diagnosis, and in 60–80% of cases of advanced disease.
Jin-Ying Gong, Zhen-Hao Zhang, Wei Zhang, Hui-Jun Wang, Xiao-Fang Feng, Ji Zhou, Guo-Qing Zhu   +6 more
doaj   +1 more source

Effects of a novel pharmacologic inhibitor of myeloperoxidase in a mouse atherosclerosis model. [PDF]

PLoS ONE, 2012
Inflammation and oxidative stress play fundamental roles in the pathogenesis of atherosclerosis. Myeloperoxidase has been extensively implicated as a key mediator of inflammatory and redox-dependent processes in atherosclerosis.
Cuiqing Liu, Rajagopal Desikan, Zhekang Ying, Liubov Gushchina, Thomas Kampfrath, Jeffrey Deiuliis, Aixia Wang, Xiaohua Xu, Jixin Zhong, Xiaoquan Rao, Qinghua Sun, Andrei Maiseyeu, Sampath Parthasarathy, Sanjay Rajagopalan   +13 more
doaj   +1 more source

Prognostic Importance of C-KIT Mutations in Core Binding Factor Acute Myeloid Leukemia: A Systematic Review

Hematology/Oncology and Stem Cell Therapy, 2017
Objective/background: Acute myeloid leukemia (AML) is defined as leukemic blast reproduction in bone marrow. Chromosomal abnormalities form different subgroups with joint clinical specifications and results.
Hossein Ayatollahi, Arezoo Shajiei, Mohammad Hadi Sadeghian, Maryam Sheikhi, Ehsan Yazdandoust, Masumeh Ghazanfarpour, Seyyede Fatemeh Shams, Sepideh Shakeri   +7 more
doaj   +1 more source

The co-receptor Neuropilin-1 enhances proliferation in inv(16) acute myeloid leukemia via VEGF signaling. [PDF]

Leukemia
Oncogenic programs regulate the proliferation and maintenance of cancer stem cells, and can define pharmacologic dependencies. In acute myeloid leukemia (AML) with the chromosome inversion 16 (inv(16)), the fusion oncoprotein CBFβ::MYH11 regulates ...
Hegde M, Ahmad MH, Mulet Lazaro R, Sugita M, Li R, Hu K, Gebhard C, Guzman ML, Bushweller JH, Zhu LJ, Brehm M, Wolfe SA, Delwel R, Castilla LH.   +13 more
europepmc   +2 more sources

BAALC-Expressing Leukemia Hematopoietic Stem Cells and Their Place in the Study of CBF-Positive Acute Myeloid Leukemias in Children and Adults

Клиническая онкогематология, 2023
Background. Due to changing views on pathogenesis, risk factors and therapy strategies in prognostically favorable CBF-positive acute myeloid leukemias[1] (AML), the expression monitoring of RUNX1/RUNX1T1 or CBFB/MYH11 fusion genes, as an additional ...
M. M. Kanunnikov, Nikolai Nikolaevich Mamaev, T. L. Gindina, A. I. Shakirova, A. M. Sadykov, S. V. Razumova, S. N. Bondarenko, L. S. Zubarovskaya   +7 more
doaj   +1 more source

Complex genomic rearrangements at the PLP1 locus include triplication and quadruplication. [PDF]

PLoS Genetics, 2015
Inverted repeats (IRs) can facilitate structural variation as crucibles of genomic rearrangement. Complex duplication-inverted triplication-duplication (DUP-TRP/INV-DUP) rearrangements that contain breakpoint junctions within IRs have been recently ...
Christine R Beck, Claudia M B Carvalho, Linda Banser, Tomasz Gambin, Danielle Stubbolo, Bo Yuan, Karen Sperle, Suzanne M McCahan, Marco Henneke, Pavel Seeman, James Y Garbern, Grace M Hobson, James R Lupski   +12 more
doaj   +1 more source