Results 31 to 40 of about 4,377,369 (241)

Transcriptome Profiling of Pediatric Core Binding Factor AML. [PDF]

PLoS ONE, 2015
The t(8;21) and Inv(16) translocations disrupt the normal function of core binding factors alpha (CBFA) and beta (CBFB), respectively. These translocations represent two of the most common genomic abnormalities in acute myeloid leukemia (AML) patients ...
Chih-Hao Hsu, Cu Nguyen, Chunhua Yan, Rhonda E Ries, Qing-Rong Chen, Ying Hu, Fabiana Ostronoff, Derek L Stirewalt, George Komatsoulis, Shawn Levy, Daoud Meerzaman, Soheil Meshinchi   +11 more
doaj   +1 more source

Acute monoblastic leukemia with abnormal eosinophils and inversion (16): A rare entity

Indian Journal of Pathology and Microbiology, 2016
Acute myeloid leukemia (AML) is a malignant hematopoietic stem cell disorder which is sub-classified based on bone marrow morphology and the presence of specific genetic abnormalities.
Kiruthiga Kala Gnanasekaran, Mary P Chacko, Marie Therese Manipadam, M S Bindra, Biju George, Vivi M Srivastava   +5 more
doaj   +1 more source

inv(16)(p13q22)

, 1997
Review on inv(16)(p13q22), with data on clinics, and the genes ...
Huret, JL
core   +1 more source

Co-expression of the CBFβ-MYH11 and BCR-ABL fusion genes in chronic myeloid leukaemia / Coexistenţa genelor de fuziune CBFβ-MYH11 şi BCR-ABL în leucemia mieloidă cronică

Romanian Journal of Laboratory Medicine, 2015
Coexistenţa t(9;22) şi a inv(16) a fost descrisă într-un număr limitat de cazuri de LMC, LAM de novo sau LAM post chimioterapie. Raportăm un pacient cu LMC care a prezentat atât inversie de 16 cât şi cromozom Philadelphia şi care a evoluat spre criză ...
Popescu Roxana, Dăscălescu Angela, Dănăilă Cătălin, Ghiorghiu Doramina, Zlei Mihaela, Ivanov Anca, Sireteanu Adriana, Gorduza Eusebiu Vlad, Azoicăi Doina   +8 more
doaj   +1 more source

Primary peritoneal myeloid sarcoma in association with CBFB/MYH11 fusion

Leukemia Research Reports, 2021
Myeloid sarcoma, also known as chloroma or granulocytic sarcoma is an extramedullary disease process that typically presents in association with acute myeloid leukemia during initial presentation or at relapse. Often associated with cytogenetic mutations,
Justin J. Kuhlman, Zaid H. Abdel Rahman, Liuyan Jiang, David M. Menke, James M. Foran, Hemant S. Murthy   +5 more
doaj   +1 more source

Pattern‐Aware Intelligence Enables Nondestructive, Rapid Quantification of High‐Aspect‐Ratio Silicon Etching

Advanced Science, EarlyView.
Pattern‐dependent etching is converted into a physical prior for intelligent reconstruction of high‐aspect‐ratio silicon structures. Combining YOLO‐Pose feature extraction with a topography network, the framework retrieves depth, sidewall angle, and scallop texture from minimal destructive observations, enabling accurate cross‐scale metrology and near ...
Shuyan He, Lang Chen, Bo Wen, Yufeng Jin, Wei Wang   +4 more
wiley   +1 more source

Characteristics and outcome of patients with core-binding factor acute myeloid leukemia and FLT3-ITD: results from an international collaborative study

Haematologica, 2021
The aim of this study was to evaluate the prognostic impact of FLT3-ITD in core-binding factor acute myeloid leukemia (CBFAML) in an international, multicenter survey of 97 patients of whom 52% had t(8;21)(q22;q22) and 48% had inv(16)(p13q22)/t(16;16 ...
Sabine Kayser, Michael Kramer, David Martínez-Cuadrón, Justin Grenet, Klaus H. Metzeler, Zuzana Sustkova, Marlise R. Luskin, Andrew M. Brunner, Michelle A. Elliott, Cristina Gil, Sandra Casal Marini, Zdeněk Ráčil, Petr Cetkovsky, Jan Novak, Alexander E. Perl, Uwe Platzbecker, Friedrich Stölzel, Anthony D. Ho, Christian Thiede, Richard M. Stone, Christoph Röllig, Pau Montesinos, Richard F. Schlenk, Mark J. Levis   +23 more
doaj   +1 more source

FISH identifies inv(16)(p13q22) masked by translocations in three cases of acute myeloid leukemia

, 1998
The inv(lb)(p13q22) masked by different translocations was detected by fluorescence in situ hybridization (FISH) and confirmed by molecular analysis in three adult patients presenting with acute myeloid leukemia (AML)-M2 (cases I and 3) and M4Eo (case 2).
Speleman, Franki, VRANCKX, H, Selleslag, D., DIERLAMM, J, Vranckx, H., SELLESLAG, D, Stul, M., CASSIMAN, JJ, Kramer, M.D., Kramer, Martin, Speleman, F., Noens, L., Noens, Lucien, Van den Berghe, H, Cassiman, JJ., Cassiman, J.J., HAGEMEIJER, A, Kramer, MHH, Olde Weghuis, D.E.M., Hagemeijer, Anne, Vranckx, HENRI, STUL, M, Michaux, L., Michaux, Lucienne, Weghuis, DEMO, Berghe, H. van den, Noens, LA, Hagemeijer, A., MICHAUX, L, Dierlamm, J.   +29 more
core   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

IMPACT OF KIT MUTATIONS IN ACUTE MYELOID LEUKAEMIA WITH INV(16)

, 2008
Several studies have recently pointed out the adverse impact of KIT mutations (mutKIT) on relapse incidence (RI) and overall survival (OS) in patients with t(8;21) AML.
C. Castagnola, C. Cattaneo, P. Colapietro, E. Ravelli, A. Beghini, A. Viola, M. Lazzarino, C. B. Ripamonti, E. Di Bona, G. Grillo, E. Morra, G. B. Bertani, F. Ferrara, E. Ottaviani, G. Rossi, P. Pioltelli, G. Martinelli, R. C. Cairoli, G. Nadali, G. Nador, A. Cuneo, G. Pizzolo   +21 more
core   +2 more sources