Results 171 to 180 of about 136,416 (329)

Move beyond free radical theory of aging

open access: yesiMetaOmics, EarlyView.
Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley   +1 more source

ECCFP: A consecutive full pass‐based bioinformatic analysis for eccDNA identification from long‐read sequencing data

open access: yesiMetaOmics, EarlyView.
A new bioinformatics pipeline called ECCFP has been developed to improve the detection of extrachromosomal circular DNA (eccDNA) from long‐read sequencing data. ECCFP uses all consecutive full passes from individual reads for candidate eccDNA identification and consolidates candidate eccDNAs to generate accurate unique eccDNA.
Wang Li   +14 more
wiley   +1 more source

Guidance for unbiased predictive information for healthcare decision-making and equity (GUIDE): considerations when race may be a prognostic factor. [PDF]

open access: yesNPJ Digit Med
Ladin K   +13 more
europepmc   +1 more source

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

open access: yesInterdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li   +10 more
wiley   +1 more source

Evaluation of routine care of prurigo nodularis in Germany: retrospective chart review study (ADVANCE PN). [PDF]

open access: yesJ Dtsch Dermatol Ges
von Kiedrowski R   +5 more
europepmc   +1 more source

Housing Security, Relative Deprivation, and Subjective Well‐Being: Empirical Evidence Derived From CFPS Data

open access: yesInternational Studies of Economics, EarlyView.
ABSTRACT The housing issue significantly influences individuals' well‐being. As a crucial mechanism for alleviating the housing issue, the housing security system has garnered increasing attention regarding its impact on residents' happiness. Utilizing data from the China Household Tracking Survey (CFPS), this paper seeks to thoroughly investigate the ...
Lingzhen Yao, Bei Qiao, Yuhan Hu
wiley   +1 more source

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