Results 61 to 70 of about 2,058,197 (242)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Structurally corrected invariant-preserving neural networks for conservative dynamical systems: a statistically validated approach

Scientific Journal of King Faisal University: Basic and Applied Sciences
In this paper a structural correction in neural network architecture for the long-time integration of conservative dynamical systems is used to overcome uncontrolled invariant drift existing in standard physics-informed formulations.
Fatima Ouaar
doaj   +1 more source

Weyl-invariant Einstein–Cartan gravity with a heavy ALP: Higgs inflation and α-attractors

Physics Letters B
We initiate the analysis of the inflationary dynamics in Weyl-invariant Einstein–Cartan gravity nonminimally coupled to the Standard Model of particle physics.
Georgios K. Karananas, Mikhail Shaposhnikov, Sebastian Zell   +2 more
doaj   +1 more source

Preface

EPJ Web of Conferences, 2016
I review the main features and some of the theoretical attempts to explain the excess around an invariant mass of 750 GeV seen in 2015 at the LHC in the di-photon channel. As this hint to new physics has now all but disappeared from the higher-luminosity
Bruno G.E., Chiodini G., Colangelo P., Corianò C., Creanza D.M., De Fazio F., Nappi E., Spagnolo S.   +7 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Refined characterization of student perspectives on quantum physics [PDF]

, 2010
The perspectives of introductory classical physics students can often negatively influence how those students later interpret quantum phenomena when taking an introductory course in modern physics.
Charles Baily, Baily, Charles, Finkelstein, Noah D., Noah D. Finkelstein   +3 more
core   +1 more source

CERA: A Framework for Improved Generalization of Machine Learning Models to Changed Climates

Journal of Advances in Modeling Earth Systems
Robust generalization under climate change remains a major challenge for machine learning applications in climate science. Most existing approaches struggle to extrapolate beyond the climate they were trained on, leading to a strong dependence on ...
Shuchang Liu, Paul A. O’Gorman
doaj   +1 more source

Higgs inflation in Weyl-invariant Einstein-Cartan gravity

Physics Letters B
In this short note we analyze the inflationary dynamics in Weyl-invariant Einstein-Cartan gravity coupled to the Standard Model of particle physics.
Georgios K. Karananas, Mikhail Shaposhnikov   +1 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source