Results 81 to 90 of about 576,686 (295)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Scale-invariant dynamical fluctuations in jet physics [PDF]

open access: yesThe European Physical Journal C, 1999
An interpretation of scale-invariant multiplicity fluctuations inside hadronic jets is presented. It is based on the branching mechanism with the angular ordering of soft partons in sequential branchings. A relationship with fractal distributions is demonstrated.
openaire   +3 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Hausdorff dimension of repellors in low sensitive systems

open access: yes, 2000
Methods to estimate the Hausdorff dimension of invariant sets of scattering systems are presented. Based on the levels' hierarchical structure of the time delay function, these techniques can be used in systems whose future-invariant-set codimensions are
A.E. Motter   +7 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Weyl-invariant Einstein–Cartan gravity with a heavy ALP: Higgs inflation and α-attractors

open access: yesPhysics Letters B
We initiate the analysis of the inflationary dynamics in Weyl-invariant Einstein–Cartan gravity nonminimally coupled to the Standard Model of particle physics.
Georgios K. Karananas   +2 more
doaj   +1 more source

Preface

open access: yesEPJ Web of Conferences, 2016
I review the main features and some of the theoretical attempts to explain the excess around an invariant mass of 750 GeV seen in 2015 at the LHC in the di-photon channel. As this hint to new physics has now all but disappeared from the higher-luminosity
Bruno G.E.   +7 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Higgs inflation in Weyl-invariant Einstein-Cartan gravity

open access: yesPhysics Letters B
In this short note we analyze the inflationary dynamics in Weyl-invariant Einstein-Cartan gravity coupled to the Standard Model of particle physics.
Georgios K. Karananas   +1 more
doaj   +1 more source

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